Development of the Drosophila nervous system: Roles for TGF-β signaling and the glypican Dally-like
AuthorRawson, Joel Michael
AdvisorSelleck, Scott B.
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractIntercellular signaling is vital for the coordinated development of multicellular organisms. This is true for all tissue types including those that constitute the nervous system. The research described here explores the role of intercellular signaling in two vital steps of nervous system development, axon pathfinding and synapse maturation/modulation. The first chapter of this dissertation explores the role of the Transforming Growth Factor-Beta signaling pathway in the modulation of synaptic function and morphology at the Drosophila melanogaster neuromuscular junction. The second chapter explores the role of the glypican Dally-like in the process of axon outgrowth and axon guidance in the same organism. Glypicans are members of the heparan sulfate proteoglycan family of molecules and are required for the proper signal transduction of various intercellular pathways including TGF-beta. Therefore both of the projects that compose this research explore the important role of intercellular signaling in development of the nervous system.
Degree ProgramGraduate College