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    Disposition of indium in male Fisher-344 rats following intratracheal or oral administration of the III-V intermetallic semiconductor material, indium phosphide

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    azu_td_1344024_sip1_m.pdf
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    Author
    Monteleone, Jonathan Patrick, 1966-
    Issue Date
    1991
    Keywords
    Health Sciences, Education.
    Health Sciences, Pharmacology.
    Environmental Sciences.
    Advisor
    Carter, Dean E.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    A sensitive method measuring indium levels >1 ppb (ng/ml) in biological tissues was developed using graphite furnace atomic absorption spectrophotometry. Single oral and pulmonary exposure of uniformly sized indium phosphide particles (mean count diameter = 1.73 ± 0.85 μm) to rats at three dose levels. Indium was deposited throughout tissues after 4 days. Bone, hair, skin, liver and kidney contained the largest indium concentrations (ng Indium/gram tissue) in both studies. Total percent dose found in tissues by either route resulted in an estimated absorption of <0.5% (not including lung for pulmonary study) except in the oral low dose group. Here the percent dose found in tissues was about 5.0% of the administered dose. The lung retained >50% of the administered dose four days following intratracheal instillation. The major route of indium elimination for both oral and pulmonary studies was in the feces; >78% of the administered dose by two days following oral gavage and >26% of the administered dose following intratracheal instillation.
    Type
    text
    Thesis-Reproduction (electronic)
    Degree Name
    M.S.
    Degree Level
    masters
    Degree Program
    Graduate College
    Pharmacology & Toxicology
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

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