Disposition kinetics of amphotericin B in rats
Publisher
The University of Arizona.Rights
Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.Abstract
Plan for the investigation of pharmacokinetics of amphotericin B (AmB) in rats. The disposition kinetics of AmB as a function of dose was characterized in this research project to improve the therapeutic usage of this drug. Male Sprague-Dawley rats were randomly divided into three different dose groups, receiving high, medium and low dose of AmB. Serum samples and urine samples were collected and assayed by HPLC. There are no significant differences for half-life, volume of distribution or systemic clearance as a function of dose. However, renal clearance decreases when the total infused dose increases. Creatinine clearance decreases significantly in the high dose group, suggesting the occurrence of nephrotoxicity. We conclude that volume of distribution and systemic clearance are linear over the dose range studied. The dose-dependent renal clearance may be due to either the nephrotoxicity associated with AmB or saturable secretion.Type
textThesis-Reproduction (electronic)
Degree Name
M.S.Degree Level
mastersDegree Program
Graduate CollegePharmaceutical Sciences