Induction of ovotoxicity by 4-vinylcyclohexene and butadiene diepoxide in B6C3F₁ mice and F344 rats
AuthorPierce, Debra Ann
AdvisorHoyer, Patricia B.
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractThe occupational chemicals 4-vinylcyclohexene (VCH) and butadiene diepoxide (BDE) have shown an ovarian effect in small pre-antral follicles in mice and rats (Flaws et al., 1994b; Doerr et al. , 1995). VCH exists as two enantiomers, S-VCH and R-VCH. Daily dosing with the enantiomers affected small primary follicles and wet tissue weights in B6C3F₁ mice. The S-enantiomer decreased small primary follicle numbers (P < 0.05) and both enantiomers reduced the weights of the ovary and uterus (p < 0.05). The results suggest the S-VCH enantiomer may have a greater ovotoxic effect as compared to the R-VCH enantiomer. In F344 rats, daily dosing with BDE reduced overall body weight (p < 0.05). There was no affect on ovarian follicle numbers. However, other ovarian effects were seen: decreased ovarian weights, delayed vaginal opening, decreased CL numbers and decreased caspase-3 activity in large antral follicles. Overall, BDE had a general toxic effect with a more specific effect in the ovary.
Degree ProgramGraduate College