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dc.contributor.advisorPark, Douglas L.en_US
dc.contributor.authorManteiga, Raquel, 1963-
dc.creatorManteiga, Raquel, 1963-en_US
dc.date.accessioned2013-05-16T09:50:59Z
dc.date.available2013-05-16T09:50:59Z
dc.date.issued1991en_US
dc.identifier.urihttp://hdl.handle.net/10150/292011
dc.description.abstractThree commercially available herbal tea preparations (Weightless, Female Toner, and PMS) and one single ingredient herbal preparation, Chaparral (Larrea tridentata), were sequentially extracted with solvents of decreasing polarity (water, methanol and chloroform) and the crude extracts obtained screened for toxic/mutagenic potentials using the brine shrimp (Artemia sp.), mouse acute toxicity, Salmonella/microsomal mutagenicity, and chicken embryo bioassays. The crude aqueous extract from Weightless Tea was very toxic to brine shrimp larvae and had a cathartic action in mice at the highest concentration tested. While Weightless tea crude water extract was not mutagenic to Salmonella typhimurium TA100 at the concentrations tested, three chromatographic isolates obtained from a silica Gel 60 column were mutagenic to the test organism. Two of these isolates were detoxified after inclusion of a microsomal activation system. The teratogenic potentials of these isolates are unknown as the results obtained from the chicken embryo bioassay were not conclusive.
dc.language.isoen_USen_US
dc.publisherThe University of Arizona.en_US
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en_US
dc.subjectAgriculture, Food Science and Technology.en_US
dc.subjectHealth Sciences, Toxicology.en_US
dc.subjectHealth Sciences, Nutrition.en_US
dc.titleToxic and mutagenic potentials of herbal teasen_US
dc.typetexten_US
dc.typeThesis-Reproduction (electronic)en_US
thesis.degree.grantorUniversity of Arizonaen_US
thesis.degree.levelmastersen_US
dc.identifier.proquest1343590en_US
thesis.degree.disciplineGraduate Collegeen_US
thesis.degree.disciplineNutrition and Food Scienceen_US
thesis.degree.nameM.S.en_US
dc.identifier.bibrecord.b26794196en_US
refterms.dateFOA2018-08-30T04:01:54Z
html.description.abstractThree commercially available herbal tea preparations (Weightless, Female Toner, and PMS) and one single ingredient herbal preparation, Chaparral (Larrea tridentata), were sequentially extracted with solvents of decreasing polarity (water, methanol and chloroform) and the crude extracts obtained screened for toxic/mutagenic potentials using the brine shrimp (Artemia sp.), mouse acute toxicity, Salmonella/microsomal mutagenicity, and chicken embryo bioassays. The crude aqueous extract from Weightless Tea was very toxic to brine shrimp larvae and had a cathartic action in mice at the highest concentration tested. While Weightless tea crude water extract was not mutagenic to Salmonella typhimurium TA100 at the concentrations tested, three chromatographic isolates obtained from a silica Gel 60 column were mutagenic to the test organism. Two of these isolates were detoxified after inclusion of a microsomal activation system. The teratogenic potentials of these isolates are unknown as the results obtained from the chicken embryo bioassay were not conclusive.


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