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    Effects of Constant Track Running Exercise on the Expression of the Immediate Early Gene Arc in the Rat Hippocampus

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    Author
    Kumar, Sabhya
    Issue Date
    2013
    Advisor
    Barnes, Carol A.
    
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    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Arc is an IEG expressed in the CA1 sub-field of the hippocampus, following stimulus from an external environment and is expressed in the place cells involved in spatial learning. An initial experiment showed that Arc expression levels decreased with 25 minute rest periods between sessions. The current study aimed to see if similar results are seen with track running, if the rest periods are removed. The rats ran on a small circular track, ensuring that a small ensemble of place cells activate on each lap. Animals were assigned to 4 groups: positive control for Arc induced by MECS; negative control for animals sacrificed from their home cage; a 5 minute group and a 45 minute group. The brain tissue was stained using FISH. The 45 minute group had a 4% lower Arc expression than the 5 minute group. A univariate ANOVA indicated a statistically significant effect in the main factor of Behavioral Group (F= 6.955, p=0.03). Tukey tests showed that the differences between the MECS and the CC groups (p<0.05) and the MECS and the 45 minute groups (p<0.05) were significant. The behavioral groups showed no statistical significance meaning that massed exposure without rest does not attenuate Arc signal.
    Type
    text
    Electronic Thesis
    Degree Name
    B.S.
    Degree Level
    bachelors
    Degree Program
    Honors College
    Molecular and Cellular Biology
    Degree Grantor
    University of Arizona
    Collections
    Honors Theses

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