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    The Effects of Various Pharmacological Agents on the Sleep and Locomotor Activity of Drosophila Models of ALS

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    Author
    Lin, Ivy Carmen
    Issue Date
    2013
    Advisor
    Zarnescu, Daniela
    
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    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    Amyotrophic Lateral Sclerosis (ALS) is a lethal, adult-onset, progressive neurodegenerative disease in which the degeneration and death of motor neurons results in muscle weakness and paralysis throughout the body, followed by death due to respiratory failure. As a RNA-binding protein, TDP-43 has been implicated as both a cause and marker of both familial (fALS) and sporadic (sALS) cases of the disease. Our laboratory has generated a Drosophila model of ALS based on human TDP-43, which allows us to study various aspects of the disease pathology in vivo, including sleep and locomotor activity. Because pharmacological treatment of ALS is currently limited to alleviating symptoms, with severely limited effects on the increase in survival period, studies of potential therapeutics would significantly contribute to the treatment of the disease. In identifying potential candidates, 4-aminoquinoline (AAQ) has shown potential in increasing survival of Drosophila TDP-43 mutants. Using the Trikinetics Drosophila Activity Monitoring system, we examine the ability of AAQ to ameliorate defects in sleep and locomotor activity in our model. Our data indicate that AAQ can decrease sleep fragmentation, suggesting that this small molecule has the potential to be developed as a drug therapy for ALS.
    Type
    text
    Electronic Thesis
    Degree Name
    B.S.
    Degree Level
    bachelors
    Degree Program
    Honors College
    Molecular and Cellular Biology
    Degree Grantor
    University of Arizona
    Collections
    Honors Theses

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