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    Radiation and Immunity in the Context of Cytomegalovirus and Aging

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    Author
    Pugh, Jason L.
    Issue Date
    2013
    Keywords
    Genetics
    Advisor
    Nikolich-Zugich, Janko
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Abstract
    The impact of ionizing radiation exposure on the immune system is dramatic and potentially lethal. The mechanism behind the radiosensitivity of immune subsets has been the concern of researchers for decades, while the long-term effects of radiation exposure in youth have been scarcely explored. The life-long impact of very prevalent latent human viruses, such as Cytomegalovirus (CMV), have recently been brought to the forefront of aging research. However, most short and long-term studies of radiation on the immune system have been performed with animals devoid of latent viruses. Here we describe an innate cause for immune subset radiosensitivity differences, and introduce a post-exposure intervention. We also describe the effects of latent CMV on acute immune sensitivity. Further, we discover that the long-term impact of radiation exposure on the immune system is dependent on whether or not latent CMV was present at the time of exposure. These findings intersect with the research fields of DNA repair, radiobiology, virology, aging, basic immunity, and stand to inform future radiation policy and research.
    Type
    text
    Electronic Dissertation
    Degree Name
    Ph.D.
    Degree Level
    doctoral
    Degree Program
    Graduate College
    Genetics
    Degree Grantor
    University of Arizona
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