The effect of a neurological checklist on nursing observations of the neurological patient
AuthorBauer, Anna Jane, 1946-
Nervous System Diseases -- nursing
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
Degree GrantorUniversity of Arizona
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Reliability and validity of the clinical neurologic assessment (CNA) tool in elderly adults with brain injuryCrosby, Leanna; Cavanaugh, Ellen Mary (The University of Arizona., 1995)The Clinical Neurologic Assessment (CNA) Instrument (Crosby & Parsons, 1989) was developed to assess for subtle changes in the level of consciousness of traumatically brain injured individuals. The instrument has been refined from a 56-item tool to a nine-item tool. This research determined the reliability and validity of the refined nine-item CNA instruments when used to assess brain injured elderly. Internal Consistency of the CNA using Cronbach' alpha demonstrated the total CNA estimated at .96. Concurrent validity of the CNA using Pearson's Product-Moment Correlation Coefficients was .94 for the CNA and the Glasgow Coma Scale (GCS) . The CNA proved to be a reliable and valid instrument for determining changes in the level of consciousness in the elderly brain injured patient.
Reliability and validity of the Clinical Neurologic Assessment (CNA) Tool in children with head traumaCrosby, Leanna; Gillespie, Stephanie Marie, 1958- (The University of Arizona., 1990)The Clinical Neurologic Assessment (CNA) Tool is a 21 item instrument designed to assess subtle neurologic changes that often accompany head trauma. This descriptive study was designed to test the reliability and validity of the CNA in children with head trauma. Interrater reliability of the CNA was assessed by determining Cohen's Kappa values for each item. Kappa values ranged from .74 to 1.00. Internal consistency of the CNA was assessed using Cronbach's alpha. The total CNA alpha was estimated to be .98 with subscale alphas ranging from .89 to .96. Concurrent and construct validity of the CNA were also assessed. Concurrent validity was estimated by determining Pearson's Product-Moment Correlation Coefficients for the CNA and the Glasgow Coma Scale (GCS) (r = .93; p = .001). Pearson's correlation coefficients were also estimated based on severity of head trauma (r = .57 to .74; p ≤ .017) and the age of the subject (r = .89 to .99; p ≤ .001). Construct validity was assessed using exploratory factor analysis which demonstrated a three factor solution. These factors reflected the following: a general overview of the level of consciousness, overall body and extremity position and movement, and muscle tone of the extremities.
Mass Spectrometric Analysis of Neurologically-Relevant MoleculesHeien, Michael L.; Smith, Catherine L.; Heien, Michael L.; Aspinwall, Craig; Armstrong, Neal; Marty, Michael; Restifo, Linda (The University of Arizona., 2018)The analysis and quantitation of neurologically-relevant molecules requires detection methods that are sensitive, selective, and applicable to a wide range of molecules. Targeted analysis using tandem mass spectrometry allows for the detection of molecules from complex matrices with an added level of selectivity. Mass spectrometry is on the leading edge of technological advances and improvements in our understanding of the intricate workings of the brain, allowing us to develop better models and better therapeutic approaches. In this thesis, I use tandem mass spectrometry to investigate two classes of neurochemicals: classical neurotransmitters, and potential therapeutic drugs based on endogenous neuropeptides. Chapter 1 will introduce existing sampling techniques and detection schemes for small molecule neurotransmitters and small peptides. We will also introduce two key concepts: insect models for understanding human neurotransmission, and the role of the blood-brain barrier in developing CNS-active pharmaceuticals. In Chapter 2 we develop a method to quantify small molecule neurotransmitters in tissue homogenate for the purpose of understanding how the bulk content of an insect brain can change under differing circumstances. Our approach allows for the analysis of a wider range of compounds with improved throughput compared to existing methods. Chapter 3 expands this method for the quantitation of five biogenic amines in Apis mellifera, to investigate the effect of infection by the microsporidian Nosema ceranae. Chapter 4 explores the role of glycosylation on the stability and blood-brain barrier permeability of peptide-based drugs. Chapter 5 expands this work to a series of Angiotensin 1-7 derivatives, for a study of the effect of different structural modifications to peptide-based drugs, with the goal of driving drug development toward more effective pharmaceuticals. Chapter 6 concludes this work and outlines the future directions of the research.