CHARACTERIZATION AND TARGETING OF THE MULTIPLE DNA SECONDARY STRUCTURES IN THE KRAS PROXIMAL PROMOTER TO MODULATE GENE EXPRESSION
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AuthorKaiser, Christine Elizabeth
AdvisorHurley, Laurence H.
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PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
EmbargoDissertation not available (per author's request)
AbstractKRAS is a well-validated drug target for anti-cancer therapy, yet no clinically useful drugs that directly inhibit its function currently exist. We aim to target KRAS at the transcriptional level, through DNA secondary structures.
Degree ProgramGraduate College