Investigating Meningeal Ion Channels As New Molecular Targets For Migraine
| dc.contributor.advisor | Drussor, Gregory | en |
| dc.contributor.author | Wei, Xiaomei | |
| dc.creator | Wei, Xiaomei | en |
| dc.date.accessioned | 2015-08-11T17:59:26Z | en |
| dc.date.available | 2015-08-11T17:59:26Z | en |
| dc.date.issued | 2014 | en |
| dc.identifier.uri | http://hdl.handle.net/10150/565832 | en |
| dc.description.abstract | This dissertation will present the four manuscripts I published or am ready to publish on the study of the pathophysiology of migraine headache. The first chapter will discuss the background of the current understanding of migraine pathophysiology. Chapter 2 is focused on studying how Transient receptor potential vanilloid 4 (TRPV4) might play a role in migraine headache. Chapter 3 is the study of a novel cell type: dural fibroblasts might also play an active role in migraine headache. Chapter 4 is discussing Norepinephrine's role in headache pathophysiology. Chapter 5 is studying the combined effect of Acid and ATP in the pathophysiology of migraine headache. The dissertation will end in a conclusion in Chapter 6. | |
| dc.language.iso | en_US | en |
| dc.publisher | The University of Arizona. | en |
| dc.rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. | en |
| dc.subject | Dural fibroblasts | en |
| dc.subject | Ion Channel | en |
| dc.subject | Migraine | en |
| dc.subject | NE | en |
| dc.subject | TRPV4 | en |
| dc.subject | Medical Pharmacology | en |
| dc.subject | ASIC | en |
| dc.title | Investigating Meningeal Ion Channels As New Molecular Targets For Migraine | en_US |
| dc.type | text | en |
| dc.type | Electronic Dissertation | en |
| thesis.degree.grantor | University of Arizona | en |
| thesis.degree.level | doctoral | en |
| dc.contributor.committeemember | Drussor, Gregory | en |
| dc.contributor.committeemember | Price, Theodore | en |
| dc.contributor.committeemember | Porreca, Frank | en |
| dc.contributor.committeemember | Vanderah, Todd W. | en |
| dc.contributor.committeemember | Ghosh, Sourav | en |
| thesis.degree.discipline | Graduate College | en |
| thesis.degree.discipline | Medical Pharmacology | en |
| thesis.degree.name | Ph.D. | en |
| refterms.dateFOA | 2018-09-10T00:30:32Z | |
| html.description.abstract | This dissertation will present the four manuscripts I published or am ready to publish on the study of the pathophysiology of migraine headache. The first chapter will discuss the background of the current understanding of migraine pathophysiology. Chapter 2 is focused on studying how Transient receptor potential vanilloid 4 (TRPV4) might play a role in migraine headache. Chapter 3 is the study of a novel cell type: dural fibroblasts might also play an active role in migraine headache. Chapter 4 is discussing Norepinephrine's role in headache pathophysiology. Chapter 5 is studying the combined effect of Acid and ATP in the pathophysiology of migraine headache. The dissertation will end in a conclusion in Chapter 6. |
