Network-based instrumentation systems are rapidly replacing traditional fixed serial interconnected instrumentation in both commercial and military flight test environments. Modern network-based flight test systems are composed of large numbers of devices including high-speed network switches, data acquisition devices, recorders, telemetry interfaces, and wireless network transceivers, all of which must be managed in a coordinated fashion. Management of the network system includes configuring, controlling, and monitoring the health and status of the various devices. Configuration by hand is not a realistic option, so algorithms for automatic management must be implemented to make these systems economical and practical. This paper describes the issues that must be addressed for managing network-based flight test systems and describes a network management approach that was developed and employed to manage a large-scale network-based flight test system.