Epigenetic Mechanisms for Long-Term Memory Acquisition and Maintenance

Abstract

In this review, we will explore the evidence that supports an epigenetic foundation for learning and memory. Through this, we will first review the basics of both learning and memory before delving into the foundational mechanisms for epigenetics. Understanding this, we will examine the evidence that suggest a link between epigenetics and long-term memory by observing two distinct directionalities: 1) the procession of learning into consolidation of a memory, and how this affects an organisms genetic code, and 2) the manifestation of change in behavior as a result of the aforementioned epigenetic changes to an organism's DNA. Beyond this, lapses in our current understanding will be discussed, and suggestions for future work will be outlined.