The Effects of the Insulin Signaling Pathway on TDP-43 Toxicity in Amyotrophic Lateral Sclerosis
AuthorRiffer, Michelle Kori
AdvisorZarnescu, Daniela C.
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractThe causes of Amyotrophic Lateral Sclerosis, a fatal neurodegenerative disease that results in skeletal muscle paralysis, are not clear; however, the nuclear RNA-binding protein TDP-43 has been suggested to play a critical role in ALS pathology. A previous drug screen that demonstrated lethality rescue in flies administered anti-diabetic drugs hinted that perhaps the Insulin signaling pathway in motor neurons might be mediating TDP-43 toxicity. Therefore, our original hypothesis was simple in that we reasoned that the insulin pathway was interacting with TDP-43. Eventually, our larval turning, lethality and eye phenotype assays have allowed us to further hypothesize that insulin resistance in motor neurons is contributing to TDP-43 neurotoxicity.
Degree ProgramHonors College
Molecular and Cellular Biology