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Recent Submissions

  • A new modeling and inference approach for the Systolic Blood Pressure Intervention Trial outcomes

    Yang, Song; Ambrosius, Walter T; Fine, Lawrence J; Bress, Adam P; Cushman, William C; Raj, Dominic S; Rehman, Shakaib; Tamariz, Leonardo; Univ Arizona, Coll Med (SAGE PUBLICATIONS LTD, 2018-06)
    Background/aims In clinical trials with time-to-event outcomes, usually the significance tests and confidence intervals are based on a proportional hazards model. Thus, the temporal pattern of the treatment effect is not directly considered. This could be problematic if the proportional hazards assumption is violated, as such violation could impact both interim and final estimates of the treatment effect. Methods We describe the application of inference procedures developed recently in the literature for time-to-event outcomes when the treatment effect may or may not be time-dependent. The inference procedures are based on a new model which contains the proportional hazards model as a sub-model. The temporal pattern of the treatment effect can then be expressed and displayed. The average hazard ratio is used as the summary measure of the treatment effect. The test of the null hypothesis uses adaptive weights that often lead to improvement in power over the log-rank test. Results Without needing to assume proportional hazards, the new approach yields results consistent with previously published findings in the Systolic Blood Pressure Intervention Trial. It provides a visual display of the time course of the treatment effect. At four of the five scheduled interim looks, the new approach yields smaller p values than the log-rank test. The average hazard ratio and its confidence interval indicates a treatment effect nearly a year earlier than a restricted mean survival time-based approach. Conclusion When the hazards are proportional between the comparison groups, the new methods yield results very close to the traditional approaches. When the proportional hazards assumption is violated, the new methods continue to be applicable and can potentially be more sensitive to departure from the null hypothesis.
  • Interaction Among Magmas from Various Sources and Crustal Melting Processes During Continental Collision: Insights from the Huayang Intrusive Complex of the South Qinling Belt, China

    Hu, Fangyang; Liu, Shuwen; Ducea, Mihai N; Zhang, Wanyi; Chapman, James B; Fu, Jinghao; Wang, Maojiang; Univ Arizona, Dept Geosci (OXFORD UNIV PRESS, 2018-04)
    The Qinling Orogenic Belt in central China, which resulted from continent-continent collision, is an excellent area for the study of collision-related magmatism. An integrated study including detailed field investigations, petrography, mineral and whole-rock geochemistry, zircon U-Pb-Hf-O isotopes, and geochemical modeling was carried out on the Huayang intrusive complex-a key magmatic intrusion in the South Qinling Belt-in order to understand the nature and melt source regions of magmatism associated with continental collisional orogenesis. The Huayang intrusive complex is composed of similar to 207-202 Ma medium to fine-grained granite, coarse to medium-grained granite of the same age, similar to 214-207 Ma tonalite and granodiorite, and rare similar to 218-213 Ma mafic xenoliths. The mafic xenoliths are characterized by enriched large ion lithophile elements, with zircon eHf(t) values of -6.8 to+4.1 and average zircon delta O-18 of 6.1 parts per thousand, which suggests that the xenoliths may represent melts derived from phlogopite-bearing lithospheric mantle. The tonalites and granodiorites exhibit high Sr/Y and La/Yb, but low Rb/Sr, with variable zircon eHf(t) values of - 6.7 to +1..9 and zircon delta O-18 values of 5.3 parts per thousand to 9.0 parts per thousand. We suggest that they were derived from partial melting of Neoproterozoic, low delta O-18 basaltic rocks with a minor input of mafic magma. These melts underwent fractional crystallization and assimilated high delta O-18 crustal materials during magma ascent and emplacement. The coarse to medium-grained granitic rocks have zircon epsilon Hf(t) values of -7.3 to +1.5, with low zircon delta O-18 values (average 5.7 parts per thousand). The medium to fine-grained granitic rocks have zircon eHf(t) values of -14.7 to +1.1, with high zircon delta O-18 values (average 8.4 parts per thousand). Both of these granitic rock types show similar whole-rock geochemistry, with metaluminous to strongly peraluminous compositions, and are characterized by intermediate to low Sr/Y values. We propose that the coarse to medium-grained granites originated from partial melting of low delta O-18 Neoproterozoic metabasaltic to metatonalitic rocks, and that the medium to fine-grained granites were derived from high delta O-18 Neoproterozoic metagreywackes. Both granitic magma types experienced plagioclase-dominated fractional crystallization during magma ascent and emplacement. The data suggest that three different source materials were involved in magmatism in the South Qinling Belt: 1) the lithospheric mantle; 2) low delta O-18 Neoproterozoic metabasaltic to tonalitic rocks, and 3) high delta O-18 Neoproterozoic metagreywackes. Slab break-off and/or dehydration of the subducted slab may have induced the melting of the sub-continental lithospheric mantle and caused subsequent crustal melting by heating the base of the crust. The results of this study suggest that magmatism in continental collisional orogens is not only generated by heating from radioactive element decay during crustal thickening.
  • Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers.

    Harryman, William L; Pond, Erika; Singh, Parminder; Little, Andrew S; Eschbacher, Jennifer M; Nagle, Raymond B; Cress, Anne E; The University of Arizona Cancer Center, 1515 N. Campbell Ave., Tucson, Arizona, United States (e-Century Publishing, 2016-01-01)
    The laminin-binding integrin (LBI) family are cell adhesion molecules that are essential for invasion and metastasis of human epithelial cancers and cell adhesion mediated drug resistance. We investigated whether copy number alteration (CNA) or mutations of a five-gene signature (ITGB4, ITGA3, LAMB3, PLEC, and SYNE3), representing essential genes for LBI adhesion, would correlate with patient outcomes within human epithelial-type tumor data sets currently available in an open access format. We investigated the relative alteration frequency of an LBI signature panel (integrin β4 (ITGB4), integrin α3 (ITGA3), laminin β3 chain (LAMB3), plectin (PLEC), and nesprin 3 (SYNE3)), independent of the epithelial cancer type, within publically available and published data using cBioPortal and Oncomine software. We rank ordered the results using a 20% alteration frequency cut-off and limited the analysis to studies containing at least 100 samples. Kaplan-Meier survival curves were analyzed to determine if alterations in the LBI signature correlated with patient survival. The Oncomine data mining tool was used to compare the heat map expression of the LBI signature without SYNE3 (as this was not included in the Oncomine database) to drug resistance patterns. Twelve different cancer types, representing 5,647 samples, contained at least a 20% alteration frequency of the five-gene LBI signature. The frequency of alteration ranged from 38.3% to 19.8%. Within the LBI signature, PLEC was the most commonly altered followed by LAMB3, ITGB4, ITGA3, and SYNE3 across all twelve cancer types. Within cancer types, there was little overlap of the individual amplified genes from each sample, suggesting different specific amplicons may alter the LBI adhesion structures. Of the twelve cancer types, overall survival was altered by CNA presence in bladder urothelial carcinoma (p=0.0143*) and cervical squamous cell carcinoma and endocervical adenocarcinoma (p=0.0432*). Querying the in vitro drug resistance profiles with the LBI signature demonstrated a positive correlation with cells resistant to inhibitors of HDAC (Vorinostat, Panobinostat) and topoisomerase II (Irinotecan). No correlation was found with the following agents: Bleomycin, Doxorubicin, Methotrexate, Gemcitabine, Docetaxel, Bortezomib, and Shikonen. Our work has identified epithelial-types of human cancer that have significant CNA in our selected five-gene signature, which was based on the essential and genetically-defined functions of the protein product networks (in this case, the LBI axis). CNA of the gene signature not only predicted overall survival in bladder, cervical, and endocervical adenocarcinoma but also response to chemotherapy. This work suggests that future studies designed to optimize the gene signature are warranted.
  • Search for top-squark pair production in final states with one lepton, jets, and missing transverse momentum using 36 fb(-1) of root s=13 TeV pp collision data with the ATLAS detector

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S. H.; AbouZeid, O. S.; Abraham, N. L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A. A.; Afik, Y.; Agatonovic-Jovin, T.; Agheorghiesei, C.; Aguilar-Saavedra, J. A.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Akerstedt, H.; Åkesson, T. P. A.; Akilli, E.; Akimov, A. V.; Alberghi, G. L.; Albert, J.; Albicocco, P.; Alconada Verzini, M. J.; Alderweireldt, S. C.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S. P.; Allbrooke, B. M. M.; Allen, B. W.; Allport, P. P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A. A.; Alstaty, M. I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M. G.; Amadio, B. T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amoroso, S.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, J. K.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D. J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J. P.; Araujo Ferraz, V.; Arce, A. T. H.; Ardell, R. E.; Arduh, F. A.; Arguin, J-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Armitage, L. J.; Cheu, E.; Univ Arizona, Dept Phys (SPRINGER, 2018-06-21)
    The results of a search for the direct pair production of top squarks, the supersymmetric partner of the top quark, in final states with one isolated electron or muon, several energetic jets, and missing transverse momentum are reported. The analysis also targets spin-0 mediator models, where the mediator decays into a pair of dark-matter particles and is produced in association with a pair of top quarks. The search uses data from proton-proton collisions delivered by the Large Hadron Collider in 2015 and 2016 at a centre-of-mass energy of root s = 13TeV and recorded by the ATLAS detector, corresponding to an integrated luminosity of 36 fb(-1). A wide range of signal scenarios with different mass-splittings between the top squark, the lightest neutralino and possible intermediate supersymmetric particles are considered, including cases where the W bosons or the top quarks produced in the decay chain are off-shell. No significant excess over the Standard Model prediction is observed. The null results are used to set exclusion limits at 95% confidence level in several supersymmetry benchmark models. For pair-produced top-squarks decaying into top quarks, top-squark masses up to 940 GeV are excluded. Stringent exclusion limits are also derived for all other considered top-squark decay scenarios. For the spin-0 mediator models, upper limits are set on the visible cross-section.
  • Search for supersymmetry in final states with missing transverse momentum and multiple b-jets in proton-proton collisions at root s=13 TeV with the ATLAS detector

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S. H.; AbouZeid, O. S.; Abraham, N. L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A. A.; Agatonovic-Jovin, T.; Agheorghiesei, C.; Aguilar-Saavedra, J. A.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Akerstedt, H.; Åkesson, T. P. A.; Akilli, E.; Akimov, A. V.; Alberghi, G. L.; Albert, J.; Albicocco, P.; Alconada Verzini, M. J.; Alderweireldt, S. C.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S. P.; Allbrooke, B. M. M.; Allen, B. W.; Allport, P. P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A. A.; Alstaty, M. I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M. G.; Amadio, B. T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amorim, A.; Amoroso, S.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, J. K.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D. J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J. P.; Araujo Ferraz, V.; Arce, A. T. H.; Ardell, R. E.; Arduh, F. A.; Arguin, J-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Armitage, L. J.; Cheu, E.; Univ Arizona, Dept Phys (SPRINGER, 2018-06-21)
    A search for supersymmetry involving the pair production of gluinos decaying via third-generation squarks into the lightest neutralino ((chi) over tilde (0)(1)) is reported. It uses LHC proton-proton collision data at a centre-of-mass energy root s = 13TeV with an integrated luminosity of 36.1 fb(-1) collected with the ATLAS detector in 2015 and 2016. The search is performed in events containing large missing transverse momentum and several energetic jets at least three of which must be identified as originating from b-quarks. To increase the sensitivity the sample is divided into subsamples based on the presence or absence of electrons or muons. No excess is found above the predicted background. For (chi) over tilde (0)(1) masses below approximately 300 GeV gluino masses of less than 1.97 (1.92) TeV are excluded at 95% confidence level in simplified models involving the pair production of gluinos that decay via top (bottom) squarks. An interpretation of the limits in terms of the branching ratios of the gluinos into third-generation squarks is also provided. These results improve upon the exclusion limits obtained with the 3.2 fb(-1) of data collected in 2015."
  • Search for Higgs boson decays to beyond-the-Standard-Model light bosons in four-lepton events with the ATLAS detector at root s=13 TeV

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S. H.; AbouZeid, O. S.; Abraham, N. L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A. A.; Afik, Y.; Agatonovic-Jovin, T.; Agheorghiesei, C.; Aguilar-Saavedra, J. A.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Akerstedt, H.; Åkesson, T. P. A.; Akilli, E.; Akimov, A. V.; Alberghi, G. L.; Albert, J.; Albicocco, P.; Alconada Verzini, M. J.; Alderweireldt, S. C.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S. P.; Allbrooke, B. M. M.; Allen, B. W.; Allport, P. P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A. A.; Alstaty, M. I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M. G.; Amadio, B. T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amoroso, S.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, J. K.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D. J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J. P.; Araujo Ferraz, V.; Arce, A. T. H.; Ardell, R. E.; Arduh, F. A.; Arguin, J-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Armitage, L. J.; Cheu, E.; Univ Arizona, Dept Phys (SPRINGER, 2018-06-29)
    A search is conducted for a beyond-the-Standard-Model boson using events where a Higgs boson with mass 125 GeV decays to four leptons (l = e or mu). This decay is presumed to occur via an intermediate state which contains one or two on-shell, promptly decaying bosons: H -> ZX/XX -> 4l , where X is a new vector boson Z(d) or pseudoscalar a with mass between 1 and 60 GeV. The search uses pp collision data collected with the ATLAS detector at the LHC with an integrated luminosity of 36.1 fb(-1) at a centre-of-mass energy root s = 13TeV. No significant excess of events above Standard Model background predictions is observed; therefore, upper limits at 95% confidence level are set on model-independent fiducial cross-sections, and on the Higgs boson decay branching ratios to vector and pseudoscalar bosons in two benchmark models.
  • Search for W ' -> tb decays in the hadronic final state using pp collisions at root s=13 TeV with the ATLAS detector

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S.H.; AbouZeid, O.S.; Abraham, N.L.; Abramowicz, H.; Abreu, H.; Abulaiti, Y.; Acharya, B.S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adiguzel, A.; Adye, T.; Affolder, A.A.; Afik, Y.; Agheorghiesei, C.; Aguilar-Saavedra, J.A.; Ahlen, S.P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Åkesson, T.P.A.; Akilli, E.; Akimov, A.V.; Alberghi, G.L.; Albert, J.; Albicocco, P.; Alconada Verzini, M.J.; Alderweireldt, S.; Aleksa, M.; Aleksandrov, I.N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S.P.; Allaire, C.; Allbrooke, B.M.M.; Allen, B.W.; Allport, P.P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A.A.; Alstaty, M.I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M.G.; Amadio, B.T.; Amaral Coutinho, Y.; Ambroz, L.; Amelung, C.; Amidei, D.; Amor Dos Santos, S.P.; Amoroso, S.; Amrouche, C.S.; Anastopoulos, C.; Ancu, L.S.; Andari, N.; Andeen, T.; Anders, C.F.; Anders, J.K.; Anderson, K.J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A.V.; Annovi, A.; Antel, C.; Anthony, M.T.; Antonelli, M.; Antrim, D.J.A.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J.P.; Araujo Ferraz, V.; Araujo Pereira, R.; Arce, A.T.H.; Ardell, R.E.; Arduh, F.A.; Arguin, J-F.; Argyropoulos, S.; Armbruster, A.J.; Armitage, L.J.; Arnaez, O.; Univ Arizona, Dept Phys (ELSEVIER SCIENCE BV, 2018-06-10)
    A search for W'-boson production in the W' -> t (b) over bar -> q (q) over bar 'b (b) over bar decay channel is presented using 36.1 fb(-1) of 13 TeV proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider in 2015 and 2016. The search is interpreted in terms of both a left-handed and a right-handed chiral W' boson within the mass range 1-5 TeV. Identification of the hadronically decaying top quark is performed using jet substructure tagging techniques based on a shower deconstruction algorithm. No significant deviation from the Standard Model prediction is observed and the results are expressed as upper limits on the W' -> t (b) over bar production cross-section times branching ratio as a function of the W'-boson mass. These limits exclude W' bosons with right-handed couplings with masses below 3.0 TeV and W' bosons with left-handed couplings with masses below 2.9 TeV, at the 95% confidence level. (C) 2018 The Author. Published by Elsevier B.V.
  • Search for squarks and gluinos in final states with jets and missing transverse momentum using 36 fb(-1) of root s=13 TeV pp collision data with the ATLAS detector

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S. H.; AbouZeid, O. S.; Abraham, N. L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A. A.; Agatonovic-Jovin, T.; Agheorghiesei, C.; Aguilar-Saavedra, J. A.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Akerstedt, H.; Åkesson, T. P. A.; Akilli, E.; Akimov, A. V.; Alberghi, G. L.; Albert, J.; Albicocco, P.; Alconada Verzini, M. J.; Alderweireldt, S. C.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S. P.; Allbrooke, B. M. M.; Allen, B. W.; Allport, P. P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A. A.; Alstaty, M. I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M. G.; Amadio, B. T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amorim, A.; Amoroso, S.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, J. K.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D. J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J. P.; Araujo Ferraz, V.; Arce, A. T. H.; Ardell, R. E.; Arduh, F. A.; Arguin, J-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Armitage, L. J.; Cheu, E.; Univ Arizona, Dept Phys (AMER PHYSICAL SOC, 2018-06-06)
    A search for the supersymmetric partners of quarks and gluons (squarks and gluinos) in final states containing hadronic jets and missing transverse momentum, but no electrons or muons, is presented. The data used in this search were recorded in 2015 and 2016 by the ATLAS experiment in root s = 13 TeV proton-proton collisions at the Large Hadron Collider, corresponding to an integrated luminosity of 36.1 fb(-1). The results are interpreted in the context of various models where squarks and gluinos are pair produced and the neutralino is the lightest supersymmetric particle. An exclusion limit at the 95% confidence level on the mass of the gluino is set at 2.03 TeV for a simplified model incorporating only a gluino and the lightest neutralino, assuming the lightest neutralino is massless. For a simplified model involving the strong production of mass-degenerate first-and second-generation squarks, squark masses below 1.55 TeVare excluded if the lightest neutralino is massless. These limits substantially extend the region of supersymmetric parameter space previously excluded by searches with the ATLAS detector.
  • Search for long-lived charginos based on a disappearing-track signature in pp collisions at root s=13 TeV with the ATLAS detector

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S. H.; AbouZeid, O. S.; Abraham, N. L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A. A.; Agatonovic-Jovin, T.; Agheorghiesei, C.; Aguilar-Saavedra, J. A.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Akerstedt, H.; Åkesson, T. P. A.; Akilli, E.; Akimov, A. V.; Alberghi, G. L.; Albert, J.; Albicocco, P.; Alconada Verzini, M. J.; Alderweireldt, S. C.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S. P.; Allbrooke, B. M. M.; Allen, B. W.; Allport, P. P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A. A.; Alstaty, M. I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M. G.; Amadio, B. T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amorim, A.; Amoroso, S.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, J. K.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D. J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J. P.; Araujo Ferraz, V.; Arce, A. T. H.; Ardell, R. E.; Arduh, F. A.; Arguin, J-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Armitage, L. J.; Cheu, E.; Univ Arizona, Dept Phys (SPRINGER, 2018-06-05)
    This paper presents a search for direct electroweak gaugino or gluino pair production with a chargino nearly mass-degenerate with a stable neutralino. It is based on an integrated luminosity of 36.1 fb(-1) of pp collisions at root s = 13 TeV collected by the ATLAS experiment at the LHC. The final state of interest is a disappearing track accompanied by at least one jet with high transverse momentum from initial-state radiation or by four jets from the gluino decay chain. The use of short track segments reconstructed from the innermost tracking layers significantly improves the sensitivity to short chargino lifetimes. The results are found to be consistent with Standard Model predictions. Exclusion limits are set at 95% confidence level on the mass of charginos and gluinos for different chargino lifetimes. For a pure wino with a lifetime of about 0.2 ns chargino masses up to 460 GeV are excluded. For the strong production channel gluino masses up to 1.65 TeV are excluded assuming a chargino mass of 460 GeV and lifetime of 0.2 ns."
  • Search for a new heavy gauge-boson resonance decaying into a lepton and missing transverse momentum in 36 fb(-1) of pp collisions root s=13 TeV with the ATLAS experiment

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S. H.; AbouZeid, O. S.; Abraham, N. L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A. A.; Agatonovic-Jovin, T.; Agheorghiesei, C.; Aguilar-Saavedra, J. A.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Akerstedt, H.; Åkesson, T. P. A.; Akilli, E.; Akimov, A. V.; Alberghi, G. L.; Albert, J.; Albicocco, P.; Alconada Verzini, M. J.; Alderweireldt, S. C.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S. P.; Allbrooke, B. M. M.; Allen, B. W.; Allport, P. P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A. A.; Alstaty, M.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M. G.; Amadio, B. T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amorim, A.; Amoroso, S.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, J. K.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D. J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J. P.; Araujo Ferraz, V.; Arce, A. T. H.; Ardell, R. E.; Arduh, F. A.; Arguin, J-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Armitage, L. J.; Cheu, E.; Univ Arizona, Dept Phys (SPRINGER, 2018-05-22)
    The results of a search for new heavy W' bosons decaying to an electron or muon and a neutrino using proton-proton collision data at a centre-of-mass energy of root s = 13 TeV are presented. The dataset was collected in 2015 and 2016 by the ATLAS experiment at the Large Hadron Collider and corresponds to an integrated luminosity of 36.1 fb(-1). As no excess of events above the Standard Model prediction is observed, the results are used to set upper limits on the W' boson cross-section times branching ratio to an electron or muon and a neutrino as a function of the W' mass. Assuming a W' boson with the same couplings as the Standard Model W boson, W' masses below 5.1 TeV are excluded at the 95% confidence level.
  • Measurement of the production cross-section of a single top quark in association with a Z boson in proton-proton collisions at 13 TeV with the ATLAS detector

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S.H.; AbouZeid, O.S.; Abraham, N.L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B.S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A.A.; Afik, Y.; Agatonovic-Jovin, T.; Agheorghiesei, C.; Aguilar-Saavedra, J.A.; Ahlen, S.P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Akerstedt, H.; Åkesson, T.P.A.; Akilli, E.; Akimov, A.V.; Alberghi, G.L.; Albert, J.; Albicocco, P.; Alconada Verzini, M.J.; Alderweireldt, S.C.; Aleksa, M.; Aleksandrov, I.N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S.P.; Allbrooke, B.M.M.; Allen, B.W.; Allport, P.P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A.A.; Alstaty, M.I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M.G.; Amadio, B.T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S.P.; Amoroso, S.; Amundsen, G.; Anastopoulos, C.; Ancu, L.S.; Andari, N.; Andeen, T.; Anders, C.F.; Anders, J.K.; Anderson, K.J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A.V.; Anjos, N.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D.J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J.P.; Araujo Ferraz, V.; Arce, A.T.H.; Ardell, R.E.; Arduh, F.A.; Arguin, J-F.; Argyropoulos, S.; Arik, M.; Armbruster, A.J.; Armitage, L.J.; Cheu, E.; Univ Arizona, Dept Phys (ELSEVIER SCIENCE BV, 2018-05-10)
    The production of a top quark in association with a Z boson is investigated. The proton-proton collision data collected by the ATLAS experiment at the LHC in 2015 and 2016 at a centre-of-mass energy of root s = 13 TeV are used, corresponding to an integrated luminosity of 36.1 fb(-1). Events containing three identified leptons (electrons and/or muons) and two jets, one of which is identified as a b-quark jet are selected. The major backgrounds are diboson, tt($)over-bar and Z + jets production. A neural network is used to improve the background rejection and extract the signal. The resulting significance is 4.2 sigma in the data and the expected significance is 5.4 sigma. The measured cross-section for tZq production is 600 +/- 170(stat.)+/- 140(syst.)fb. (C) 2018 The Author(s). Published by Elsevier B.V.
  • Measurement of the production cross section of three isolated photons in pp collisions at root s=8 TeV using the ATLAS detector

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S.H.; AbouZeid, O.S.; Abraham, N.L.; Abramowicz, H.; Abreu, H.; Abulaiti, Y.; Acharya, B.S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A.A.; Afik, Y.; Agheorghiesei, C.; Aguilar-Saavedra, J.A.; Ahlen, S.P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Åkesson, T.P.A.; Akilli, E.; Akimov, A.V.; Alberghi, G.L.; Albert, J.; Albicocco, P.; Alconada Verzini, M.J.; Alderweireldt, S.; Aleksa, M.; Aleksandrov, I.N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S.P.; Allaire, C.; Allbrooke, B.M.M.; Allen, B.W.; Allport, P.P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A.A.; Alstaty, M.I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M.G.; Amadio, B.T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S.P.; Amoroso, S.; Anastopoulos, C.; Ancu, L.S.; Andari, N.; Andeen, T.; Anders, C.F.; Anders, J.K.; Anderson, K.J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A.V.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D.J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J.P.; Araujo Ferraz, V.; Arce, A.T.H.; Ardell, R.E.; Arduh, F.A.; Arguin, J-F.; Argyropoulos, S.; Armbruster, A.J.; Armitage, L.J.; Arnaez, O.; Arnold, H.; Arratia, M.; Arslan, O.; Artamonov, A.; Cheu, E.; Univ Arizona, Dept Phys (ELSEVIER SCIENCE BV, 2018-06-10)
    A measurement of the production of three isolated photons in proton-proton collisions at a centre-of-mass energy root s = 8 TeV is reported. The results are based on an integrated luminosity of 20.2 fb(-1) collected with the ATLAS detector at the LHC. The differential cross sections are measured as functions of the transverse energy of each photon, the difference in azimuthal angle and in pseudorapidity between pairs of photons, the invariant mass of pairs of photons, and the invariant mass of the triphoton system. A measurement of the inclusive fiducial cross section is also reported. Next-to-leading-order perturbative QCD predictions are compared to the cross-section measurements. The predictions underestimate the measurement of the inclusive fiducial cross section and the differential measurements at low photon transverse energies and invariant masses. They provide adequate descriptions of the measurements at high values of the photon transverse energies, invariant mass of pairs of photons, and invariant mass of the triphoton system. (C) 2018 The Author. Published by Elsevier B.V.
  • Measurement of the inclusive and fiducial t(t)over-bar production cross-sections in the lepton plus jets channel in pp collisions at root s=8 TeV with the ATLAS detector

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S. H.; AbouZeid, O. S.; Abraham, N. L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A. A.; Afik, Y.; Agatonovic-Jovin, T.; Agheorghiesei, C.; Aguilar-Saavedra, J. A.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Akerstedt, H.; Åkesson, T. P. A.; Akilli, E.; Akimov, A. V.; Alberghi, G. L.; Albert, J.; Albicocco, P.; Alconada Verzini, M. J.; Alderweireldt, S. C.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S. P.; Allbrooke, B. M. M.; Allen, B. W.; Allport, P. P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A. A.; Alstaty, M. I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M. G.; Amadio, B. T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amoroso, S.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, J. K.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D. J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J. P.; Araujo Ferraz, V.; Arce, A. T. H.; Ardell, R. E.; Arduh, F. A.; Arguin, J-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Armitage, L. J.; Cheu, E.; Univ Arizona, Dept Phys (SPRINGER, 2018-06-12)
    The inclusive and fiducial t (t) over bar production cross sections are measured in the lepton+jets channel using 20.2 fb(-1) of proton proton collision data at a centre-of mass energy of 8 TeV recorded with the ATLAS detector at the LHC. Major systematic uncertainties due to the modelling of the jet energy scale and b-tagging efficiency are constrained by separating selected events into three disjoint regions. In order to reduce systematic uncertainties in the most important background, the W+jets process is modelled using Z+jets events in a data-driven approach. The inclusive t (t) over bar cross-section is measured with a precision of 5.7% to be (sigma(inc) (t (t) over bar) = 248.3 +/- 0.7 (stat.) +/- 13.4 (syst.) +/- 4.7 (lumi.) pb, assuming a top-quark mass of 172.5 GeV. The result is in agreement with the Standard Model prediction. The cross-section is also measured in a phase space close to that of the selected data. The fiducial cross-section is sigma(fid) (t (t) over bar) = 48.8 +/- 0.1 (stat.) +/- 2.0 (syst.) +/- 0.9 (lumi.) pb with a precision of 4.5%.
  • Measurement of the Effective Weak Mixing Angle in p ¯ p → Z / γ ∗ → ℓ + ℓ − Events

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Agnew, J. P.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Askew, A.; Atkins, S.; Augsten, K.; Aushev, V.; Aushev, Y.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besançon, M.; Beuselinck, R.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Borysova, M.; Brandt, A.; Brandt, O.; Brochmann, M.; Brock, R.; Bross, A.; Brown, D.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Pérez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M.-C.; Cuth, J.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Déliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Drutskoy, A.; Dubey, A.; Dudko, L. V.; Duperrin, A.; Dutt, S.; Eads, M.; Univ Arizona (AMER PHYSICAL SOC, 2018-06-13)
    We present a measurement of the effective weak mixing angle parameter sin(2)theta(l)(eff) in p (p) over bar -> Z/gamma* -> mu(+)mu(-) events at a center-of-mass energy of 1.96 TeV, collected by the D0 detector at the Fermilab Tevatron Collider and corresponding to 8.6 fb(-1) of integrated luminosity. The measured value of sin(2)theta(l)(eff)[mu mu] = 0.23016 +/- 0.00064 is further combined with the result from the D0 measurement in p (p) over bar -> Z/gamma* -> e(+)e(-) events, resulting in sin(2)theta(l)(eff)[comb] = 0.23095 +/- 0.00040. This combined result is the most precise measurement from a single experiment at a hadron collider and is the most precise determination using the coupling of the Z/gamma* to light quarks.
  • Measurement of the cross section for isolated-photon plus jet production in pp collisions at root s=13 TeV using the ATLAS detector

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S.H.; AbouZeid, O.S.; Abraham, N.L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B.S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A.A.; Afik, Y.; Agatonovic-Jovin, T.; Agheorghiesei, C.; Aguilar-Saavedra, J.A.; Ahlen, S.P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Akerstedt, H.; Åkesson, T.P.A.; Akilli, E.; Akimov, A.V.; Alberghi, G.L.; Albert, J.; Albicocco, P.; Alconada Verzini, M.J.; Alderweireldt, S.C.; Aleksa, M.; Aleksandrov, I.N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S.P.; Allbrooke, B.M.M.; Allen, B.W.; Allport, P.P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A.A.; Alstaty, M.I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M.G.; Amadio, B.T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S.P.; Amoroso, S.; Amundsen, G.; Anastopoulos, C.; Ancu, L.S.; Andari, N.; Andeen, T.; Anders, C.F.; Anders, J.K.; Anderson, K.J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A.V.; Anjos, N.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D.J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J.P.; Araujo Ferraz, V.; Arce, A.T.H.; Ardell, R.E.; Arduh, F.A.; Arguin, J-F.; Argyropoulos, S.; Arik, M.; Armbruster, A.J.; Armitage, L.J.; Cheu, E.; Univ Arizona, Dept Phys (ELSEVIER SCIENCE BV, 2018-05-10)
    The dynamics of isolated-photon production in association with a jet in proton-proton collisions at a centre-of-mass energy of 13 TeV are studied with the ATLAS detector at the LHC using a dataset with an integrated luminosity of 3.2 fb(-1). Photons are required to have transverse energies above 125 GeV. Jets are identified using the anti-k(t) algorithm with radius parameter R = 0.4 and required to have transverse momenta above 100 GeV. Measurements of isolated-photon plus jet cross sections are presented as functions of the leading-photon transverse energy, the leading-jet transverse momentum, the azimuthal angular separation between the photon and the jet, the photon-jet invariant mass and the scattering angle in the photon-jet centre-of-mass system. Tree-level plus parton-shower predictions from SHERPA and PYTHIA as well as next-to-leading-order QCD predictions from JETPHOX and SHERPA are compared to the measurements. (C) 2018 The Author. Published by Elsevier B.V.
  • Measurement of inclusive jet and dijet cross-sections in proton-proton collisions at root s=13 TeV with the ATLAS detector

    Aaboud, M.; Aad, G.; Abbott, B.; Abdinov, O.; Abeloos, B.; Abidi, S. H.; AbouZeid, O. S.; Abraham, N. L.; Abramowicz, H.; Abreu, H.; Abreu, R.; Abulaiti, Y.; Acharya, B. S.; Adachi, S.; Adamczyk, L.; Adelman, J.; Adersberger, M.; Adye, T.; Affolder, A. A.; Afik, Y.; Agatonovic-Jovin, T.; Agheorghiesei, C.; Aguilar-Saavedra, J. A.; Ahlen, S. P.; Ahmadov, F.; Aielli, G.; Akatsuka, S.; Akerstedt, H.; Åkesson, T. P. A.; Akilli, E.; Akimov, A. V.; Alberghi, G. L.; Albert, J.; Albicocco, P.; Alconada Verzini, M. J.; Alderweireldt, S. C.; Aleksa, M.; Aleksandrov, I. N.; Alexa, C.; Alexander, G.; Alexopoulos, T.; Alhroob, M.; Ali, B.; Aliev, M.; Alimonti, G.; Alison, J.; Alkire, S. P.; Allbrooke, B. M. M.; Allen, B. W.; Allport, P. P.; Aloisio, A.; Alonso, A.; Alonso, F.; Alpigiani, C.; Alshehri, A. A.; Alstaty, M. I.; Alvarez Gonzalez, B.; Álvarez Piqueras, D.; Alviggi, M. G.; Amadio, B. T.; Amaral Coutinho, Y.; Amelung, C.; Amidei, D.; Amor Dos Santos, S. P.; Amoroso, S.; Amundsen, G.; Anastopoulos, C.; Ancu, L. S.; Andari, N.; Andeen, T.; Anders, C. F.; Anders, J. K.; Anderson, K. J.; Andreazza, A.; Andrei, V.; Angelidakis, S.; Angelozzi, I.; Angerami, A.; Anisenkov, A. V.; Anjos, N.; Annovi, A.; Antel, C.; Antonelli, M.; Antonov, A.; Antrim, D. J.; Anulli, F.; Aoki, M.; Aperio Bella, L.; Arabidze, G.; Arai, Y.; Araque, J. P.; Araujo Ferraz, V.; Arce, A. T. H.; Ardell, R. E.; Arduh, F. A.; Arguin, J-F.; Argyropoulos, S.; Arik, M.; Armbruster, A. J.; Armitage, L. J.; Cheu, E.; Univ Arizona, Dept Phys (SPRINGER, 2018-05-30)
    Inclusive jet and dijet cross-sections are measured in proton-proton collisions at a centre-of-mass energy of 13 TeV. The measurement uses a dataset with an integrated luminosity of 3.2 fb(-1) recorded in 2015 with the ATLAS detector at the Large Hadron Collider. Jets are identified using the anti-lit algorithm with a radius parameter value of R = 0.4. The inclusive jet cross-sections are measured double-differentially as a function of the jet transverse momentum, covering the range from 100 GeV to 3.5 TeV, and the absolute jet rapidity up to vertical bar y vertical bar = 3. The double-differential dijet production cross-sections are presented as a function of the dijet mass, covering the range from 300 GeV to 9 TeV, and the half absolute rapidity separation between the two leading jets within vertical bar y vertical bar < 3, y*, up to y* = 3. Next-to-leading-order, and next-to-next-to-leading-order for the inclusive jet measurement, perturbative QCD calculations corrected for non-perturbative and electroweak effects are compared to the measured cross-sections.
  • Small-scale forestry and carbon offset markets: An empirical study of Vermont Current Use forest landowner willingness to accept carbon credit programs

    White, Alisa E.; Lutz, David A.; Howarth, Richard B.; Soto, José R.; Univ Arizona, Sch Nat Resources & Environm (Public Library of Science, 2018-08-14)
    This study investigates the preferences of small forest landowners regarding forest carbon credit programs while documenting characteristics of potentially successful frameworks. We designed hypothetical carbon credit programs with aggregated carbon offset projects and requirements of existing voluntary and compliance protocols in mind. We administered a mail survey to 992 forest landowners in Vermont’s Current Use Program utilizing best-worst choice, a novel preference elicitation technique, to elicit their preferences about these programs. We found that small forest landowners see revenue as the most important factor in a carbon credit program and the duration of the program as the least important factor. Landowners reported that shorter program duration, higher revenue, and lower withdrawal penalties positively impact their willingness to accept forest carbon credit programs. Notably, our study includes carbon credit program implementer as a key program attribute, allowing us to quantify landowners’ tradeoffs between non-profit, for-profit, and government organizations. Overall, we found that landowners significantly prefer working with a non-profit organization. Based on monetary estimates of willingness-to-accept compensation, our results suggest that aggregated forest carbon offset projects incorporating small forest landowners could be piloted successfully in Vermont by non-profit organizations while maintaining relatively strict guidelines of existing carbon offset protocols.
  • Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer

    Das, Lipsa; Gard, Jaime M.C.; Prekeris, Rytis; Nagle, Raymond B.; Morrissey, Colm; Knudsen, Beatrice S.; Miranti, Cindy K.; Cress, Anne E.; Univ Arizona, Canc Biol Grad Interdisciplinary Program; Univ Arizona, Canc Ctr; Univ Arizona, Canc Ctr, Cellular & Mol Med; Univ Arizona, Canc Ctr, Mol & Cellular Biol (AMER ASSOC CANCER RESEARCH, 2018-08)
    The laminin-binding integrins, alpha 3 beta 1 and alpha 6 beta 1, are needed for tumor metastasis and their surface expression is regulated by endocytic recycling. beta 1 integrins share the Rab11 recycling machinery, but the trafficking of alpha 3 beta 1 and alpha 6 beta 1 are distinct by an unknown mechanism. Using a mouse PDX tumor model containing human metastatic prostate cancer, Rab11 family interacting protein 5 (Rab11-FIP5) was identified as a lead candidate for a6b1 trafficking. Rab11-FIP5 and its membrane-binding domain were required for alpha 6 beta 1 recycling, without affecting the other laminin-binding integrin (i.e., alpha 6 beta 1) or unrelated membrane receptors like CD44, transferrin receptor, or E-cad-herin. Depletion of Rab11-FIP5 resulted in the intracellular accumulation of alpha 6 beta 1 in the Rab11 recycling compartment, loss of cell migration on laminin, and an unexpected loss of alpha 6 beta 1 recycling in cell-cell locations. Taken together, these data demonstrate that alpha 6 beta 1 is distinct from alpha 3 beta 1 via Rab11-FIP5 recycling and recycles in an unexpected cell-cell location.
  • Wavelength Tunable Ho3+-Doped ZBLAN Fiber Lasers in the 1.2-mu m Wavelength Region

    Ma, Yunxiu; Zhu, Xiushan; Yang, Luyun; Zhang, Xinzheng; Norwood, R. A.; Peyghambarian, N.; Univ Arizona, Coll Opt Sci (IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2018-08-15)
    Wavelength tunability of continuous-wave holmium doped ZrF4-BaF2-LaT3-AlF3-NaF fiber lasers operating in the 1.2-arm wavelength region was investigated with a Littrow configuration. A wavelength tuning range of 1184-1198 nm was obtained from the fiber output port of the laser. The spectral width was measured to be around 0.02 nm over the entire tunable range and a maximum output power of 81.6 mW at 1192 nm was obtained at a pump power of 1.97 W. The wavelength tunable range was found to be limited by the transmission of the fiber-optic wavelength division multiplexer and coupler. A broader wavelength tuning range of 1177-1201 nm was obtained with a simpler fiber laser construction from the zero-order diffraction output of the bulk grating.
  • Targeting the Cohesive Cluster Phenotype in Chordoma via β1 Integrin Increases Ionizing Radiation Efficacy.

    Harryman, William L; Gard, Jaime M C; Pond, Kelvin W; Simpson, Skyler J; Heppner, Lucas H; Hernandez-Cortes, Daniel; Little, Andrew S; Eschbacher, Jennifer M; Cress, Anne E; Univ Arizona, Canc Ctr, 1515 N Campbell Ave, Tucson, AZ 85724 USA; Univ Arizona, Dept Cellular & Mol Med, 1515 N Campbell Ave, Tucson, AZ 85724 USA; Univ Arizona, Coll Med, Med Student Res Program, 1515 N Campbell Ave, Tucson, AZ 85724 USA; Univ Arizona, Canc Biol Res Program, 1515 N Campbell Ave, Tucson, AZ 85724 USA (ELSEVIER SCIENCE INC, 2017-11-01)
    Chordoma is a rare, radiation-resistant, skull-base and spinal tumor with high local recurrence containing mixed cell-adhesion phenotypes. We characterized DNA damage response (DDR) signaling (γH2AX, pKAP1, pATM) and survival response to ionizing radiation (IR) in human chordoma samples (42 resections, 23 patients) to test if blocking cell adhesion sensitizes U-CH1 tumor cells to IR. U-CH1 cells expressed brachyury, YAP, and laminin adhesion receptors (CD49c, CD49f, CD44), and approximately 15% to 20% of U-CH1 cells featured an α6 integrin-dependent (CD49f) cohesive cluster phenotype, which confers therapeutic resistance and aids metastasis. DDR to IR in U-CH1 cells was compared to normal prostate epithelial (PrEC) and tumor cells (DU145). Flow cytometry showed a dose- and time-dependent increase in γH2AX and pKAP1 expression in all cell lines. However, nearly 50% of U-CH1 cells exhibited nonresponsive phenotype to IR (measured by γH2AX and pKAP1) independent of cell cycle status. Immunofluorescence microscopy verified that only 15% of U-CH1 clustered cells were γH2AX or pKAP1 positive (versus 80% of nonclustered cells) 2 hours following 2-Gy IR. Conversely, both tumor cell lines were uniformly defective in pATM response. HYD1, a synthetic ECM ligand, inhibited DDR through an unresolved γH2AX response. β1 integrin-blocking antibody (AIIB2) decreased cell survival 50% itself and approximately doubled the IR-induced cell kill at all IR doses observed at 2 and 4 weeks posttreatment. These results suggest that a heterogeneity of DDR to IR exists within a chordoma population. Blocking integrin function alone and/or as an adjuvant to IR may eradicate chordomas containing the cohesive cluster phenotype.

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