Browsing UA Faculty Research by Journal
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Data on prior pegylated liposomal doxorubicin (PLD) treatment in recurrent ovarian cancer: Post-hoc data analysis from the phase 3 randomized, open-label study comparing trabectedin and PLD versus PLD alone in patients with recurrent ovarian cancerThe data presented herein are supplementary to our published primary article "A phase 3 randomized, open-label, multicenter trial for safety and efficacy of combined trabectedin and pegylated liposomal doxorubicin therapy for recurrent ovarian cancer". The exploratory analysis evaluated the impact of prior pegylated liposomal doxorubicin (PLD) therapy in patients who participated in a randomized, open-label study comparing combination therapy of trabectedin and PLD vs PLD alone in third-line recurrent ovarian cancer (ROC). These exploratory analyses showed that prior treatment with PLD in ROC does not impact the response and survival rates nor does it increase toxicities or negatively influence survival and response rates in both treatment groups. (C) 2020 The Author(s). Published by Elsevier Inc.
Data on the activity of DNA methyltransferase in the uteri of CD-1 mice exposed to dibutyl phthalatePhthalates are industrial chemicals used as plasticizers in food packaging, medical devices, and toys, as well as cosmetics used primarily by women. Epidemiological studies in women and animal studies using rodents have reported associations between phthalate exposures and adverse reproductive health outcomes. Epigenetic mechanisms are thought to be involved in the ability of environmental contaminants to influence development of disease but evidence linking exposure to phthalates and uterine DNA methyltransferase activity are lacking. This article reports the activity of DNA methyltransferase (DNMT) enzymes in uteri from CD-1 mice treated with or without dibutyl phthalate (DBP), a phthalate commonly found in the urine of women of reproductive age. CD-1 mice were orally dosed with tocopherol-stripped corn oil (vehicle) or DBP at 10 mu g/kg/day, 100 mu g/kg/day and 1000 mg/kg/day daily for 10, 20, and 30 days. These dosages were selected based on estimates of human intake previously reported (10 and 100 mg/kg/day) and included a high dose (1000 mg/kg/day) for comparison with classical toxicity studies. At the end of 10, 20 or 30 days of daily oral dosing, animals were euthanized within 1-2 hours after the final dose. DNMT activity was determined by subjecting uterine nuclear extracts to a commercially-available DNMT activity ELISA assay and measuring optical density with a microplate spectrophotometer at a wavelength of 450 nm. Graph Pad Prism 8 was used for data analysis to determine the activity of DNMT enzymes at different time points and doses versus vehicle. The data presented serves as a resource for researchers working in the field of toxicology because it addresses a gap in knowledge of how exposure to environmental factors such as phthalate esters could produce epigenetic alterations in the uterus, which consequently may increase the risk of developing reproductive disease. (C) 2019 The Author(s). Published by Elsevier Inc.
Environmental monitoring and exposure science dataset to calculate ingestion and inhalation of metal(loid)s through preschool gardeningMetal(loid) contamination may pose an increased risk of exposure to children residing near legacy and active resource extraction sites. Children may be exposed to arsenic, cadmium, and/or lead by ingestion and/or inhalation while engaging in school or home outdoor activities via environmental media including water, soil, dust, and locally grown produce. It is thus critical to collect site-specific data to best assess these risks. This data article provides gastric and lung in-vitro bioaccessibility assay (IVBA) data, as well as environmental monitoring data for water, soil, dust, and garden produce collected from preschools (N = 4) in mining communities throughout Nevada County, California in 2018. Arsenic, cadmium, and lead concentrations in the aforementioned media and synthetic gastric and lung fluids were measured by inductively coupled plasma-mass spectrometry (ICP-MS). This dataset provides useful metal(loid) concentrations for future risk assessments for similar settings.