• APOL1 renal risk alleles in patients on chronic hemodialysis in Northwest of Iran

      Vahed, Sepideh Zuntmi; Rikhtegar, Ehsan; Attari, Vahideh Ebrahimzadeh; Haghi, Mehdi; Tolouian, Ramin; Shojas, Mohammadali Mohajel; Ardalan, Mohammadreza; Univ Arizona, Div Nephrol (NIKAN RESEARCH INST, 2019-09)
      Introduction: Apolipoprotein L1 (APOL1) gene's risk variants located on chromosome 22 are newly discovered factors for the development of chronic renal failure among African-American. These risk alleles were developed on the African continent as an evolutionary defense against sleep sickness due to Trypanosoma brucei rhodesiense and then spread with human migrations. Objectives: In the present study, we sought to examine these risk variants in a group of hemodialysis patients of Northwest of Iran. Patients and Methods: Two hundred patients receiving hemodialysis in different centers of the city (Tabriz in Northwest of Iran) were allocated randomly from a total number of 825 patients. The assessment of APOL1 polymorphisms (rs73885319, rs60910145, and rs71785313) was conducted using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Patients' demographic data, history, and their biochemical parameters were recorded based on their last measurement. Results: No proposed renal risk variants of APOL1 gene in our hemodialysis population were found. All the participants had a wild genotype. Conclusion: The results of our study match with reports from Europe and Asia. In the paleoanthropological point of view, our results do not support African human migration hypothesis.
    • Collapsing glomerulopathy following COVID-19 infection; possible relationship with APOL1 kidney risk alleles in African-Americans

      Mubarak, Muhammed; Tolouian, Ramin; Pezeshgi, Aiyoub; Univ Arizona, Coll Med, Div Nephrol (NIKAN RESEARCH INST, 2020-05-05)
      Collapsing glomerulopathy (CG) is being increasingly reported in African American patients with COVID-19 infection during the current pandemic. It is possible that CG following COVID-19 infection in this population may be linked to underlying APOL1 kidney risk alleles, which are not uncommon in this ethnic group. This lesion should be considered in the differential diagnosis of rapidly declining renal function in association with heavy proteinuria in the setting of COVID-19 disease, especially in patients of African ancestry.