• Long-Term Ranibizumab Treatment in Neovascular Age-Related Macular Degeneration: A Belgian Subanalysis from the Global Real-World LUMINOUS (TM) Study

      Leys, Anita M; Ramboer, Eva; Favreau, Mérédis; Denhaerynck, Kris; MacDonald, Karen; Abraham, Ivo; Brié, Heidi; Univ Arizona, Ctr Hlth Outcomes & Pharmacoecon Res; Univ Arizona, Coll Pharm, Dept Pharm Practice & Sci; Univ Arizona, Dept Family & Community Med, Coll Med Tucson (DOVE MEDICAL PRESS LTD, 2020-06-02)
      Purpose: To evaluate long-term, real-world treatment patterns and outcomes of ranibizumab 0.5 mg for neovascular age-related macular degeneration (nAMD) in a Belgian cohort. Patients and Methods: This Belgian (BE) cohort of the 5-year global observational LUMINOUS study included 229 patients with nAMD. Outcomes included visual acuity (VA), central retinal thickness (CRT) and safety. Results: The mean age was 79.5 +/- 7.7 years. The majority of patients (67.7%) were female and all patients were Caucasian. Most patients previously received ranibizumab with only 17.5% of patients being treatment-naive. The injection frequency declined over time irrespective of prior treatment status (p<0.0001), with treatment-naive eyes receiving a mean of 4.2 +/- 2.9 yearly injections and prior-ranibizumab eyes 3.6 +/- 2.7. Regression analysis confirmed first-year VA increases for treatment-naive eyes (p=0.002) followed by a slight decrease of -1.8 letters per year. For prior-ranibizumab eyes, the visual changes over 1 year were statistically non-significant (p=0.90) but declined slightly after year one (p<0.0001). Anatomically, the CRT of treatment-naive eyes decreased over time from baseline (p<0.0001), whereas the CRT of prior-ranibizumab eyes remained stable (p=0.43). No new safety findings were identified. Conclusion: LUMINOUS-BE reconfirms the well-characterized benefit-risk profile of ranibizumab for nAMD treatment. The observed low injection frequency reflects a need for more rigorous treatment in real-world settings.