Now showing items 8338-8357 of 14021

    • Practical steps for an effective virtual reality course integration

      Cook, Matt; Lischer-Katz, Zack; School of Information, University of Arizona (Informa UK Limited, 2021-10-05)
      Today’s virtual reality (VR) technologies enable students to traverse immersive learning environments populated with highly engaging course content that closely resembles real-world artifacts and sites, scientific specimens, and otherwise inaccessible training scenarios. The relative affordability of the latest generation of VR hardware has further increased the uptake of VR across academic, but careful consideration must be given to how the technology is deployed for classroom use. This paper draws on a range published research literature, and the authors’ experiences implementing VR in an academic library, to present guidelines and case studies that can be used by library practitioners to craft effective VR course assignments.
    • A Practical Tutorial Discussion the Evaluating ITArtifacts Using Controlled Experiments using the Design Science Framework

      Leroy, Gondy; University of Arizona, Management Informations Systems (IEEE, 2020-11)
      This tutorial teaches how to conduct evaluations that fit within the design science paradigm, i.e., evaluations of algorithms and entire systems. Design science is of increasing importance in IS with many of the main and top journals recognizing it as an important research approach in our field. However, many business schools and i-schools focus on behavioral or econometrics when teaching evaluation. This tutorial brings the complement to this: ANOVA and t-Test for evaluation of artifacts under different conditions. © 2020 IEEE.
    • Practice guideline: Cervical and ocular vestibular evoked myogenic potential testing

      Fife, Terry D.; Colebatch, James G.; Kerber, Kevin A.; Brantberg, Krister; Strupp, Michael; Lee, Hyung; Walker, Mark F.; Ashman, Eric; Fletcher, Jeffrey; Callaghan, Brian; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2017-11-28)
      Objective: To systematically review the evidence and make recommendations with regard to diagnostic utility of cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP, respectively). Four questions were asked: Does cVEMP accurately identify superior canal dehiscence syndrome (SCDS)? Does oVEMP accurately identify SCDS? For suspected vestibular symptoms, does cVEMP/oVEMP accurately identify vestibular dysfunction related to the saccule/utricle? For vestibular symptoms, does cVEMP/oVEMP accurately and substantively aid diagnosis of any specific vestibular disorder besides SCDS? Methods: The guideline panel identified and classified relevant published studies (January 1980-December 2016) according to the 2004 American Academy of Neurology process. Results and Recommendations: Level C positive: Clinicians may use cVEMP stimulus threshold values to distinguish SCDS from controls (2 Class III studies) (sensitivity 86%-91%, specificity 90%-96%). Corrected cVEMP amplitude may be used to distinguish SCDS from controls (2 Class III studies) (sensitivity 100%, specificity 93%). Clinicians may use oVEMP amplitude to distinguish SCDS from normal controls (3 Class III studies) (sensitivity 77%-100%, specificity 98%-100%). oVEMP threshold may be used to aid in distinguishing SCDS from controls (3 Class III studies) (sensitivity 70%-100%, specificity 77%-100%). Level U: Evidence is insufficient to determine whether cVEMP and oVEMP can accurately identify vestibular function specifically related to the saccule/utricle, or whether cVEMP or oVEMP is useful in diagnosing vestibular neuritis or Meniere disease. Level C negative: It has not been demonstrated that cVEMP substantively aids in diagnosing benign paroxysmal positional vertigo, or that cVEMP or oVEMP aids in diagnosing/managing vestibular migraine.
    • Practice Makes Perfect: Experiential Learning as a Method for Financial Socialization

      LeBaron, Ashley B.; Runyan, Samuel D.; Jorgensen, Bryce L.; Marks, Loren D.; Li, Xiaohui; Hill, E. Jeffrey; Univ Arizona (SAGE PUBLICATIONS INC, 2019-03)
      Most financial socialization research focuses on two methods of learning: modeling and discussion. The purpose of this study is to qualitatively explore experiential learning as a third potential method of financial socialization used by parents. Specifically, we explored what children learned about finances through experiential learning and why parents used experiential learning as a financial socialization method. We used a multigenerational sample of emerging adults (ages 18-30 years) and their parents and grandparents (N = 115). Analyses revealed three core what themes (Working Hard, Managing Money, and Spending Wisely) and three core why themes (Learning Financial Skills, Acquiring Financial Values, and Becoming Financially Independent) related to experiential learning. These findings have implications for parents, researchers, and educators. In sum, we propose that experiential learning should be regarded as a principal method of financial socialization and should be considered in theory building, research, and pedagogy.
    • Practitioner Insights into Weed Management on California's Rangelands and Natural Areas

      Schohr, Tracy K; Gornish, Elise S; Woodmansee, Grace; Shaw, Julea; Tate, Kenneth W; Roche, Leslie M; Univ Arizona, Sch Nat Resources & Environm (SPRINGER, 2020-02)
      Working rangelands and natural areas span diverse ecosystems and face both ecological and economic threats from weed invasion. Restoration practitioners and land managers hold a voluminous cache of place-based weed management experience and knowledge that has largely been untapped by the research community. We surveyed 260 California rangeland managers and restoration practitioners to investigate invasive and weedy species of concern, land management goals, perceived effectiveness of existing practices (i.e., prescribed fire, grazing, herbicide use, and seeding), and barriers to practice implementation. Respondents identified 196 problematic plants, with yellow starthistle (Centaurea solstitialis L.) and medusahead (Elymus caput-medusae L.) most commonly listed. Reported adoption and effectiveness of weed management practices varied regionally, but the most highly rated practice in general was herbicide use; however, respondents identified considerable challenges including nontarget effects, cost, and public perception. Livestock forage production was the most commonly reported management goals (64% of respondents), and 25% of respondents were interested in additional information on using grazing to manage invasive and weedy species; however, 19% of respondents who had used grazing for weed management did not perceive it to be an effective tool. Across management practices, we also found common barriers to implementation, including operational barriers (e.g., permitting, water availability), potential adverse impacts, actual effectiveness, and public perception. Land manager and practitioner identified commonalities of primary weeds, management goals, perceived practice effectiveness, and implementation barriers across diverse bioregions highlight major needs that could be immediately addressed through management-science partnerships across the state's expansive rangelands and natural areas.
    • A pragmatist view of the metaphysics of entanglement

      Healey, Richard; Univ Arizona, Philosophy Dept (SPRINGER, 2016-09-21)
      Quantum entanglement is widely believed to be a feature of physical reality with undoubted (though debated) metaphysical implications. But Schrodinger introduced entanglement as a theoretical relation between representatives of the quantum states of two systems. Entanglement represents a physical relation only if quantum states are elements of physical reality. So arguments for metaphysical holism or nonseparability from entanglement rest on a questionable view of quantum theory. Assignment of entangled quantum states predicts experimentally confirmed violation of Bell inequalities. Can one use these experimental results to argue directly for metaphysical conclusions? No. Quantum theory itself gives us our best explanation of violations of Bell inequalities, with no superluminal causal influences and no metaphysical holism or nonseparability-but only if quantum states are understood as objective and relational, though prescriptive rather than ontic. Correct quantum state assignments are backed by true physical magnitude claims: but backing is not grounding. Quantum theory supports no general metaphysical holism or nonseparability; though a claim about a compound physical system may be significant and true while similar claims about its components are neither. Entanglement may well have have few, if any, first-order metaphysical implications. But the quantum theory of entanglement has much to teach the metaphysician about the roles of chance, causation, modality and explanation in the epistemic and practical concerns of a physically situated agent.
    • A pre-catalytic non-covalent step governs DNA polymerase β fidelity

      Alnajjar, Khadijeh S; Krylov, Ivan S; Negahbani, Amirsoheil; Haratipour, Pouya; Kashemirov, Boris A; Huang, Ji; Mahmoud, Mariam; McKenna, Charles E; Goodman, Myron F; Sweasy, Joann B; et al. (OXFORD UNIV PRESS, 2019-11-16)
      DNA polymerase beta (pol beta) selects the correct deoxyribonucleoside triphosphate for incorporation into the DNA polymer. Mistakes made by pol beta lead to mutations, some of which occur within specific sequence contexts to generate mutation hotspots. The adenomatous polyposis coli (APC) gene is mutated within specific sequence contexts in colorectal carcinomas but the underlying mechanism is not fully understood. In previous work, we demonstrated that a somatic colon cancer variant of pol beta, K289M, misincorporates deoxynucleotides at significantly increased frequencies over wild-type pol beta within a mutation hotspot that is present several times within the APC gene. Kinetic studies provide evidence that the rate-determining step of pol beta catalysis is phosphodiester bond formation and suggest that substrate selection is governed at this step. Remarkably, we show that, unlike WT, a pre-catalytic step in the K289M pol beta kinetic pathway becomes slower than phosphodiester bond formation with the APC DNA sequence but not with a different DNA substrate. Based on our studies, we propose that precatalytic conformational changes are of critical importance for DNA polymerase fidelity within specific DNA sequence contexts.
    • Pre-discovery Activity of New Interstellar Comet 2I/Borisov beyond 5 au

      Ye, Quanzhi; Kelley, Michael S. P.; Bolin, Bryce T.; Bodewits, Dennis; Farnocchia, Davide; Masci, Frank J.; Meech, Karen J.; Micheli, Marco; Weryk, Robert; Bellm, Eric C.; et al. (IOP PUBLISHING LTD, 2020-01-31)
      Comet 2I/Borisov, the first unambiguous interstellar comet ever found, was discovered in 2019 August at similar to 3 au from the Sun on its inbound leg. No pre-discovery detection beyond 3 au has yet been reported, mostly due to the comet's proximity to the Sun as seen from the Earth. Here we present a search for pre-discovery detections of comet Borisov using images taken by the Catalina Sky Survey, Pan-STARRS, and the Zwicky Transient Facility (ZTF), with a further comprehensive follow-up campaign being presented in Bolin et al. We identified comet Borisov in ZTF images taken in 2019 May and use these data to update its orbit. This allowed us to identify the comet in images acquired as far back as 2018 December, when it was 7.8 au from the Sun. The comet was not detected in 2018 November when it was 8.6 au from the Sun, possibly implying an onset of activity around this time. This suggests that the activity of the comet is either driven by a more volatile species other than H2O, such as CO or CO2, or by exothermic crystallization of amorphous ice. We derive the radius of the nucleus to be <7 km using the non-detection in 2018 November, and estimate an area of similar to 0.5-10 has been active between 2018 December and 2019 September, though this number is model-dependent and is highly uncertain. The behavior of comet Borisov during its inbound leg is observationally consistent with dynamically new comets observed in our solar system, suggesting some similarities between the two.
    • Pre-nebular Light Curves of SNe I

      Arnett, W. David; Fryer, Chris L.; Matheson, Thomas; Univ Arizona, Steward Observ (IOP PUBLISHING LTD, 2017-08-29)
      We compare analytic predictions of supernova light curves with recent high-quality data from SN2011fe (Ia), KSN2011b (Ia), and the Palomar Transient Factory and the La Silla-QUEST variability survey (LSQ) (Ia). Because of the steady, fast cadence of observations, KSN2011b provides unique new information on SNe Ia: the smoothness of the light curve, which is consistent with significant large-scale mixing during the explosion, possibly due to 3D effects (e.g., Rayleigh-Taylor instabilities), and provides support for a slowly varying leakage (mean opacity). For a more complex light curve (SN2008D, SN Ib), we separate the luminosity due to multiple causes and indicate the possibility of a radioactive plume. The early rise in luminosity is shown to be affected by the opacity (leakage rate) for thermal and non-thermal radiation. A general derivation of Arnett's rule again shows that it depends upon all processes heating the plasma, not just radioactive ones, so that SNe Ia will differ from SNe Ibc if the latter have multiple heating processes.
    • Pre-Oxfordian (> 163 Ma) Ophiolite Obduction in Central Tibet

      Ma, Anlin; Hu, Xiumian; Kapp, Paul; BouDagher-Fadel, Marcelle; Lai, Wen; Univ Arizona, Dept Geosci (AMER GEOPHYSICAL UNION, 2020-05)
      The timing of Bangong-Nujiang suture ophiolite obduction between the Lhasa and Qiangtang terranes in central Tibet is important for understanding the closure history of the Meso-Tethys but remains poorly constrained. We investigated subaerial to shallow marine strata of the Dongqiao Formation that sit unconformably on Bangong-Nujiang suture ophiolites that crystallized in a supra-subduction zone setting at 189-181 Ma. Based on foraminiferal and coral studies, the depositional age of the Dongqiao Formation is constrained to be Oxfordian and Kimmeridgian (Late Jurassic). Provenance analyses including detrital modes, geochemistry of detrital chromian spinels, and U-Pb age populations of detrital zircons suggest the Dongqiao Formation was sourced from uplifted Bangong-Nujiang suture ophiolites and sedimentary and metamorphic rocks of Lhasa terrane affinity to the south. We conclude that Bangong-Nujiang suture ophiolites were obducted soon after crystallization (prior to Oxfordian time; >163 Ma) onto the Lhasa terrane or a microcontinent of Lhasa terrane affinity. Plain Language Summary Ophiolite obduction often occurs when a passive continental margin enters an oceanic subduction zone and thus may mark when an arc-continent or continent-continent collision begins. In central Tibet, the Dongqiao ophiolite represents a relict of Meso-Tethys oceanic lithosphere. Initial research during the 1980s provided rough constraints on the timing, polarity, and mechanism of Dongqiao ophiolite obduction. However, there has been little advancement in our knowledge of the obduction history since. Here we report results of sedimentologic, stratigraphic, and provenance studies on the Dongqiao Formation overlying the Dongqiao ophiolite. Our foraminiferal and coral biostratigraphic data show that subaerial to shallow marine strata of the Dongqiao Formation were deposited between 163 and 152 million years ago. We demonstrate that the clastic rocks in the Dongqiao Formation received detritus from both the underlying Dongqiao ophiolite and Lhasa terrane affinity continental crust. We propose that a continental margin of Lhasa terrane affinity entered a north-dipping oceanic trench, and the Dongqiao ophiolite was obducted southwards on to it, no later than 163 million years ago.
    • Precipitation Influence on and Response to Early and Late Arctic Sea Ice Melt Onset During Melt Season

      Marcovecchio, Alexa; Behrangi, Ali; Dong, Xiquan; Xi, Baike; Huang, Yiyi; Department of Hydrology and Atmospheric Sciences, University of Arizona (Wiley, 2021-06-02)
      The region containing portions of the East Siberian Sea and Laptev Sea (73°–84°N, 90°–155°E) is the area of focus (AOF) for this study. The impacts of precipitation, latent heat (LH) and sensible heat (SH) fluxes on sea ice melt onset in the AOF are investigated. Four early melting years (1990, 2012, 2003, and 1991) and four late melting years (1982, 1983, 1984, and 1996) are compared to better identify the different responses to melt onset timing. A consistency check is performed between multiple Arctic precipitation products (including NASA MERRA-2, ECMWF ERA-Interim [ERA-I], and ECMWF ERA5 reanalyses as well as GPCP V2.3 observations) since there is not yet a high-quality ground-truth Arctic precipitation data product. MERRA-2 has the greatest monthly average precipitation, snowfall, evaporation, and net LH flux. ERA-I suggests that liquid precipitation starts earlier in the year than MERRA-2 and ERA5, while GPCP shows different seasonal precipitation variations from the reanalyses. MERRA-2 has the clearest and most amplified seasonal trends for the parameters used in this study, so the daily time series and anomalies of MERRA-2 variables before and after the first major melt event are investigated. ERA5 is used to check these results because ERA-I and ERA5 display similar seasonal trends. According to MERRA-2, during early melt years, surface SH flux loss and precipitation are above average in the days before and after the first major melt event. During late melt years, surface SH flux loss and precipitation are below average in the month leading up to the first major melt event. © 2021 Royal Meteorological Society
    • Precipitation susceptibility in marine stratocumulus and shallow cumulus from airborne measurements

      Jung, Eunsil; Albrecht, Bruce A.; Sorooshian, Armin; Zuidema, Paquita; Jonsson, Haflidi H.; Univ Arizona, Dept Chem & Environm Engn; Univ Arizona, Dept Hydrol & Atmospher Sci (COPERNICUS GESELLSCHAFT MBH, 2016-09-14)
      Precipitation tends to decrease as aerosol concentration increases in warm marine boundary layer clouds at fixed liquid water path (LWP). The quantitative nature of this relationship is captured using the precipitation susceptibility (So) metric. Previously published works disagree on the qualitative behavior of So in marine low clouds: So decreases monotonically with increasing LWP or cloud depth (H) in stratocumulus clouds (Sc), while it increases and then decreases in shallow cumulus clouds (Cu). This study uses airborne measurements from four field campaigns on Cu and Sc with similar instrument packages and flight maneuvers to examine if and why So behavior varies as a function of cloud type. The findings show that So increases with H and then decreases in both Sc and Cu. Possible reasons for why these results differ from those in previous studies of Sc are discussed.
    • Precipitation-induced surface brightenings seen on Titan by Cassini VIMS and ISS

      Barnes, Jason; Buratti, Bonnie; Turtle, Elizabeth; Bow, Jacob; Dalba, Paul; Perry, Jason; Brown, Robert; Rodriguez, Sebastien; Mouelic, Stephane Le; Baines, Kevin; et al. (BioMed Central, 2013)
      Observations from Cassini VIMS and ISS show localized but extensive surface brightenings in the wake of the 2010 September cloudburst. Four separate areas, all at similar latitude, show similar changes: Yalaing Terra, Hetpet Regio, Concordia Regio, and Adiri. Our analysis shows a general pattern to the time-sequence of surface changes: after the cloudburst the areas darken for months, then brighten for a year before reverting to their original spectrum. From the rapid reversion timescale we infer that the process driving the brightening owes to a fine-grained solidified surface layer. The specific chemical composition of such solid layer remains unknown. Evaporative cooling of wetted terrain may play a role in the generation of the layer, or it may result from a physical grain-sorting process.
    • Precise radial velocities of giant stars

      Ortiz, Mauricio; Reffert, Sabine; Trifonov, Trifon; Quirrenbach, Andreas; Mitchell, David S.; Nowak, Grzegorz; Buenzli, Esther; Zimmerman, Neil; Bonnefoy, Mickaël; Skemer, Andy; et al. (EDP SCIENCES S A, 2016-10-28)
      Context. For over 12 yr, we have carried out a precise radial velocity (RV) survey of a sample of 373 G- and K-giant stars using the Hamilton Echelle Spectrograph at the Lick Observatory. There are, among others, a number of multiple planetary systems in our sample as well as several planetary candidates in stellar binaries. Aims. We aim at detecting and characterizing substellar and stellar companions to the giant star HD 59686 A (HR 2877, HIP 36616). Methods. We obtained high-precision RV measurements of the star HD 59686 A. By fitting a Keplerian model to the periodic changes in the RVs, we can assess the nature of companions in the system. To distinguish between RV variations that are due to non-radial pulsation or stellar spots, we used infrared RVs taken with the CRIRES spectrograph at the Very Large Telescope. Additionally, to characterize the system in more detail, we obtained high-resolution images with LMIRCam at the Large Binocular Telescope. Results. We report the probable discovery of a giant planet with a mass of m(p) sin i = 6.92(-0.24)(+0.18) M-Jup orbiting at a(p) = 1.0860(-0.0007)(+0.0006) aufrom the giant star HD 59686 A. In addition to the planetary signal, we discovered an eccentric (e(B) = 0.729(-0.003)(+0.004)) binary companionwith a mass of m(B) sin i = 0.5296(-0.0008)(+0.0011) M-circle dot orbiting at a close separation from the giant primary with a semi-major axis of a(B) = 13.56(-0.14)(+0.18) au. Conclusions. The existence of the planet HD 59686 Ab in a tight eccentric binary system severely challenges standard giant planet formation theories and requires substantial improvements to such theories in tight binaries. Otherwise, alternative planet formation scenarios such as second-generation planets or dynamical interactions in an early phase of the system's lifetime need to be seriously considered to better understand the origin of this enigmatic planet.
    • Precise strong lensing mass profile of the CLASH galaxy cluster MACS 2129

      Monna, A.; Seitz, S.; Balestra, I.; Rosati, P.; Grillo, C.; Halkola, A.; Suyu, S. H.; Coe, D.; Caminha, G. B.; Frye, B.; et al. (OXFORD UNIV PRESS, 2017-01-07)
      We present a detailed strong lensing (SL) mass reconstruction of the core of the galaxy cluster MACS J2129.4-0741 (z(cl) = 0.589) obtained by combining high-resolution Hubble Space Telescope photometry from the CLASH (Cluster Lensing And Supernovae survey with Hubble) survey with new spectroscopic observations from the CLASH-VLT (Very Large Telescope) survey. A background bright red passive galaxy at z(sp) = 1.36, sextuply lensed in the cluster core, has four radial lensed images located over the three central cluster members. Further 19 background lensed galaxies are spectroscopically confirmed by our VLT survey, including 3 additional multiple systems. A total of 31 multiple images are used in the lensing analysis. This allows us to trace with high precision the total mass profile of the cluster in its very inner region (R < 100 kpc). Our final lensing mass model reproduces the multiple images systems identified in the cluster core with high accuracy of 0.4 arcsec. This translates to a high-precision mass reconstruction of MACS 2129, which is constrained at a level of 2 per cent. The cluster has Einstein parameter Theta(E) = (29 +/- 4) arcsec and a projected total mass of M-tot (< Theta(E)) = (1.35 +/- 0.03) x 10(14) M-circle dot within such radius. Together with the cluster mass profile, we provide here also the complete spectroscopic data set for the cluster members and lensed images measured with VLT/Visible Multi-Object Spectrograph within the CLASH-VLT survey.
    • Precision astrometry with adaptive optics: constraints on the mutual orbit of Luhman 16AB from GeMS

      Ammons, S. Mark; Garcia, E. Victor; Salama, Maissa; Neichel, Benoit; Lu, Jessica; Marois, Christian; Macintosh, Bruce; Savransky, Dmitry; Bendek, Eduardo; Guyon, Olivier; et al. (SPIE-INT SOC OPTICAL ENGINEERING, 2016-09-02)
      ELTs equipped with MCAO systems will be powerful astrometric tools in the next two decades. With sparse-field precisions exceeding 30 uas for V > 18, the ELTs will surpass even GAIA's per-epoch precision for faint stars (V > 12). We present results from an ongoing astrometry program with Gemini GeMS and discuss synergies with WFIRST and GAIA. First, we present a fit to the relative orbit of the individual L/T components of Luhman16 AB, the nearest brown dwarf binary known. Exploiting GeMS' wide field of view to image reference stars, we are able to track the relative motion to better than 0.2 mas. We find that a mutual Keplerian orbit with no perturbing planets fits the binary separation to within the measurement errors, ruling out companions down to 14 earth masses for certain orbits and periods.
    • Precision drug repurposing via convergent eQTL-based molecules and pathway targeting independent disease-associated polymorphisms

      Vitali, Francesca; Berghout, Joanne; Fan, Jungwei; Li, Jianrong; Li, Qike; Li, Haiquan; Lussier, Yves A; Univ Arizona, Ctr Biomed Informat & Biostat CB2; Univ Arizona, Dept Med COM T; Univ Arizona, Ctr Appl Genet & Genom Med; et al. (WORLD SCIENTIFIC PUBL CO PTE LTD, 2019)
      Repurposing existing drugs for new therapeutic indications can improve success rates and streamline development. Use of large-scale biomedical data repositories, including eQTL regulatory relationships and genome-wide disease risk associations, offers opportunities to propose novel indications for drugs targeting common or convergent molecular candidates associated to two or more diseases. This proposed novel computational approach scales across 262 complex diseases, building a multi-partite hierarchical network integrating (i) GWAS-derived SNP-to-disease associations, (ii) eQTL-derived SNP-to-eGene associations incorporating both cis-and trans-relationships from 19 tissues, (iii) protein target-to-drug, and (iv) drug-to-disease indications with (iv) Gene Ontology-based information theoretic semantic (ITS) similarity calculated between protein target functions. Our hypothesis is that if two diseases are associated to a common or functionally similar eGene -and a drug targeting that eGene/protein in one disease exists - the second disease becomes a potential repurposing indication. To explore this, all possible pairs of independently segregating GWAS-derived SNPs were generated, and a statistical network of similarity within each SNP-SNP pair was calculated according to scale-free overrepresentation of convergent biological processes activity in regulated eGenes (ITSeGENE-eGENE) and scale-free overrepresentation of common eGene targets between the two SNPs (ITSSNP-SNP). Significance of ITSSNP-SNP was conservatively estimated using empirical scale-free permutation resampling keeping the node-degree constant for each molecule in each permutation. We identified 26 new drug repurposing indication candidates spanning 89 GWAS diseases, including a potential repurposing of the calcium-channel blocker Verapamil from coronary disease to gout. Predictions from our approach are compared to known drug indications using DrugBank as a gold standard (odds ratio=13.1, p-value=2.49x10(-8)). Because of specific disease-SNPs associations to candidate drug targets, the proposed method provides evidence for future precision drug repositioning to a patient's specific polymorphisms.
    • Precision Glass molding for diffractive optics

      Zhang, YingYing; Zhou, Wenchen; Spires, Oliver; Kim, Young Sik; Yi, Allen; Liang, Rongguang; Milster, Tom D.; Wyant College of Optical Sciences, University of Arizona (OSA, 2020)
      We proposed a comprehensive technical scheme addressing the fabrication limitation of diamond turning, coating stability and adhesion problem during molding process,to realize high performance of diffractive optics.
    • Precision Higgs couplings in neutral naturalness models: an effective field theory approach

      Heurtier, L.; Li, H.-L.; Song, H.; Su, S.; Su, W.; Yu, J.-H.; Department of Physics, University of Arizona (Springer Science and Business Media Deutschland GmbH, 2021)
      The Higgs sector in neutral naturalness models provides a portal to the hidden sectors, and thus measurements of Higgs couplings at current and future colliders play a central role in constraining the parameter space of the model. We investigate a class of neutral naturalness models, in which the Higgs boson is a pseudo-Goldstone boson from the universal SO(N)/SO(N − 1) coset structure. Integrating out the radial mode from the spontaneous global symmetry breaking, we obtain various dimension-six operators in the Standard Model effective field theory, and calculate the low energy Higgs effective potential with radiative corrections included. We perform a χ2 fit to the Higgs coupling precision measurements at current and future colliders and show that the new physics scale could be explored up to 2.3 (2.4) TeV without (with) the Higgs invisible decay channels at future Higgs factories. The limits are comparable to the indirect constraints obtained via electroweak precision measurements. © 2021, The Author(s).
    • Precision Higgs physics at the CEPC

      Su, Shufang; Univ Arizona, Dept Phys (IOP PUBLISHING LTD, 2019-04-04)
      The discovery of the Higgs boson with its mass around 125 GeV by the ATLAS and CMS Collaborations marked the beginning of a new era in high energy physics. The Higgs boson will be the subject of extensive studies of the ongoing LHC program. At the same time, lepton collider based Higgs factories have been proposed as a possible next step beyond the LHC, with its main goal to precisely measure the properties of the Higgs boson and probe potential new physics associated with the Higgs boson. The Circular Electron Positron Collider (CEPC) is one of such proposed Higgs factories. The CEPC is an e(+)e(-) circular collider proposed by and to be hosted in China Located in a tunnel of approximately 100 km in circumference, it will operate at a center-of-mass energy of 240 GeV as the Higgs factory. In this paper, we present the first estimates on the precision of the Higgs boson property measurements achievable at the CEPC and discuss implications of these measurements.