Modern cosmology predicts that a galaxy overdensity (e.g., protocluster) will be associated with a large intergalactic medium gas reservoir, which can be traced by Ly alpha forest absorption. We have undertaken a systematic study of the relation between Coherently Strong intergalactic Lya Absorption systems (CoSLAs), which have the highest optical depth (tau) in the tau distribution, and mass overdensities on the scales of similar to 10-20 h(-1) comoving Mpc. On such large scales, our cosmological simulations show a strong correlation between the effective optical depth (tau(eff)) of the CoSLAs and the three-dimensional mass overdensity. In spectra with moderate signal-to-noise ratio, however, the profiles of CoSLAs can be confused with individual high column density absorbers. For z > 2.6, where the corresponding Ly beta is redshifted to the optical, we have developed a selection technique to distinguish between these two alternatives. We have applied this technique to similar to 6000 sight lines provided by Sloan Digital Sky Survey III quasar survey at z = 2.6-3.3 with a continuum-to-noise ratio greater than 8, and we present a sample of five CoSLA candidates with tau(eff) on 15 h(-1) Mpc greater than 4.5x the mean optical depth. At lower redshifts of z < 2.6, where the background quasar density is higher, the overdensity can be traced by intergalactic absorption groups using multiple sight lines with small angular separations. Our overdensity searches fully use the current and next generation of Ly alpha forest surveys, which cover a survey volume of > 1 (h(-1) Gpc)(3). Systems traced by CoSLAs will yield a uniform sample of the most massive overdensities at z > 2 to provide stringent constraints to models of structure formation.

Background Maintenance of lean muscle mass and related strength is associated with lower risk for numerous chronic diseases of aging in women. Objective Our aim was to evaluate whether the association between dietary protein and lean mass differs by physical activity level, amino acid composition, and body mass index categories. Design We performed a cross-sectional analysis of a prospective cohort. Participants/setting Participants were postmenopausal women from the Womens Health Initiative with body composition measurements by dual-energy x-ray absorptiometry (n=8,298). Main outcome measures Our study measured percent lean mass, percent fat mass, and lean body mass index. Statistical analyses performed Linear regression models adjusted for scanner serial number, age, calibrated energy intake, race/ethnicity, neighborhood socioeconomic status, and recreational physical activity were used to determine the relationship between protein intake and body composition measures. Likelihood ratio tests and stratified analysis were used to investigate physical activity and body mass index as potential effect modifiers. Results Biomarker-calibrated protein intake was positively associated with percent lean mass; women in the highest protein quintile had 6.3 percentage points higher lean mass than the lowest quintile (P<0.001). This difference rose to 8.5 percentage points for physically active women in the highest protein quintile (P-interaction=0.023). Percent fat mass and lean body mass index were both inversely related to protein intake (both P<0.001). Physical activity further reduced percent fat mass (P-interaction=0.022) and lean body mass index (P-interaction=0.011). Leucine intake was associated with lean mass, as were branched chain amino acids combined (both P<0.001), but not independent of total protein. All associations were observed for normal-weight, overweight, and obese women. Conclusions Protein consumption up to 2.02 g/kg body weight daily is positively associated with lean mass in postmenopausal women. Importantly, those that also engage in physical activity have the highest lean mass across body mass index categories.

How FACs-producing generalist and specialist herbivores regulate their FACs-hydrolyzing enzyme L-ACY-1 to balance FACs' beneficial vs. detrimental effects remains unknown. To address this question, we compared L-ACY-1 expression in Helicoverpa armigera and Helicoverpa assulta, a pair of closely related sibling species differing mainly in their host range, by the same sets of hostplants, protein to digestible carbohydrate (P:C) ratios, or allelochemical. L-ACY-1 expression remained low/unchanged in H. armigera, but was induced by hot pepper fruits and repressed by cotton bolls in H. assulta. The representative allelochemicals of the tested hostplants significantly (capsaicin) or insignificantly (gossypol and nicotine) induced L-ACY-1 expression in H. armigera, but insignificantly inhibited (capsaicin and gossypol) or induced (nicotine) it in H. assulta. L-ACY-1 expression remained low/unaltered on balanced (P50:C50 and P53:C47) or protein-biased diets and induced on carbohydrate-biased diets in H. armigera, but was at the highest level on balanced diets and reduced on either protein-or carbohydrate-biased diets in H. assulta. Furthermore, L-ACY-1 expression was significantly higher in H. assulta than in H. armigera for most of feeding treatments. Such expressional divergences suggest that FACs are utilized mainly for removal of excessive nitrogen in generalists but for nitrogen assimilation in specialists.

Let F/Q be a totally real field and K/F a complex multiplication (CM) quadratic extension. Let I he a cuspidal Hilbert modular new form over F. Let lambda he a Ilecke character over K such that the Rankin Selherg convolution f with the theta-series associated with lambda is self-dual with root number 1. We consider the nonvanishing of the family of central-critical Rankin Selberg L-values L(1/2, f circle times lambda(chi)), as chi varies over the class group characters of K. Our approach is geometric, relying on the Zariski density of CM points in self-products of a Hilbert modular Shimura variety. We show that the number of class group characters chi such that L(1/2, f circle times lambda(chi)) not equal 0 increases with the absolute value of the discriminant of K. We crucially rely on the Andre-Oort conjecture for arbitrary self-product of the Hilbert modular Shimura variety. In view of the recent results of Tsitnertnan, Yuan Zhang and Andreatta-Goren-Howard-Pera, the results are now unconditional. We also consider a quaternionic version. Our approach is geometric, relying on the general theory of Shimura varieties and the geometric definition of nearly holomorphic modular forms. In particular, the approach avoids any use of a suhconvex hound for the Rankin Selberg L-values. The Waklspurger formula plays an underlying role.

ObjectivesUnderstanding the difficulties faced by different migrant groups is vital to address disparities and inform targeted health-care service delivery. Migrant oncology patients experience increased morbidity, mortality and psychological distress, with this tentatively linked to language and communication difficulties. The objective of this exploratory study was to investigate the communication barriers and challenges experienced by Arabic, Greek and Chinese (Mandarin and Cantonese) speaking oncology patients in Australia. MethodsThis study employed a cross-sectional design using patient-reported outcome survey data from migrant and English-speaking Australian-born patients with cancer. Patients were recruited through oncology clinics and Australian state cancer registries. Data were collected regarding patient clinical and demographic characteristics and health-care and communication experiences. Data from the clinics and registries were combined for analysis. ResultsSignificant differences were found between migrant groups in demographic characteristics, communication and health-care experiences, and information and care preferences. Chinese patients cited problems with understanding medical information, the Australian health-care system, and communicating with their health-care team. Conversely, Arabic- and Greek-speaking patients reported higher understanding of the health-care system, and less communication difficulties. ConclusionsOur study findings suggest that migrant groups differ from each other in their health communication expectations and requirements. Lower education and health literacy of some groups may play a role in poorer health outcomes. Public health interventions and assistance provided to migrants should be tailored to the specific needs and characteristics of that language or cultural group. Future research directions are discussed.

X-ray CT based baggage scanners are widely used in security applications. Recently, there has been increased interest in view-limited systems which can improve the scanning throughput while maintaining the threat detection performance. However as very few view angles are acquired in these systems, the image reconstruction problem is challenging. Standard reconstruction algorithms such as the filtered backprojection create strong artifacts when working with view-limited data. In this work, we study the performance of a variety of reconstruction algorithms for both single and multi-energy view-limited systems.

New geochronologic, geochemical, and isotopic data for Mesozoic to Cenozoic igneous rocks and detrital minerals from the Pamir Mountains help to distinguish major regional magmatic episodes and constrain the tectonic evolution of the Pamir orogenic system. After final accretion of the Central and South Pamir terranes during the Late Triassic to Early Jurassic, the P amir was largely amagmatic until the emplacement of the intermediate (SiO2 > 60 wt.%), talc-alkaline, and isotopically evolved (-13 to -5 zircon epsilon Hf-(t)) South Pamir batholith between 120-100 Ma, which is the most volumetrically significant magmatic complex in the Pamir and includes a high flux magmatic event at similar to 105 Ma. The South Pamir batholith is interpreted as the northern (inboard) equivalent of the Cretaceous Karakoram batholith and the along-strike equivalent of an Early Cretaceous magmatic belt in the northern Lhasa terrane in Tibet. The northern Lhasa terrane is characterized by a similar high-flux event at similar to 110 Ma. Migration of continental arc magmatism into the South Pamir terrane during the mid-Cretaceous is interpreted to reflect northward directed, low-angle to flat-slab subduction of the Neo-Tethyan oceanic lithosphere. Late Cretaceous magmatism (80-70 Ma) in the Pamir is scarce, but concentrated in the Central and northern South Pamir terranes where it is comparatively more mafic (SiO2 < 60 wt.%), alkaline, and isotopically juvenile (-2 to +2 zircon epsilon Hf-(t)) than the South Pamir batholith. Late Cretaceous magmatism in the Pamir is interpreted here to be the result of extension associated with roll-back of the Neotethyan oceanic slab, which is consistent with similarly aged extension-related magmatism in the Karakoram terrane and Kohistan. There is an additional pulse of magmatism in the Pamir at 42-36 Ma that is geographically restricted (similar to 150 km diameter ellipsoidal area) and referred to as the Vanj magmatic complex. The Vanj complex comprises metaluminous, high-K talc-alkaline to shoshonitic monzonite, syenite, and granite that is adakitic (La/Yb-N = 13 to 57) with low Mg# (35-41). The Vanj complex displays a range of SiO2 (54-75 wt.%) and isotopic compositions (-7 to -3 epsilon Nd-(i), 0.706 to 0.710 Sr-87/Sr-86((i)), -3 to +1 zircon epsilon Hf-(i), 6.0 to 7.6%o zircon delta O-18(VSMOW)), which reflects some juvenile mantle input and subsequent assimilation or mixing with the Central/South Pamir terrane lower crust. The Vanj complex is speculatively interpreted to be the consequence of a mantle drip or small delamination event that was induced by India-Asia collision. The age, geochemistry, outcrop pattern, and tectonic position of the Vanj magmatic complex suggest that it is part of a series of magmatic complexes that extend for >2500 km across the Pamir and northern Qiangtang terrane in Tibet. All of these complexes are located directly south of the Tanymas-Jinsha suture zone, an important lithospheric and rheological boundary that focused mantle lithosphere deformation after India-Asia collision. Miocene magmatism (20-10 Ma) in the Pamir includes: 1) isotopically evolved migmatite and leucogranite related to crustal anataxis and decompression melting within extensional gneiss domes, and; 2) localized intra-continental magmatism in the Dunkeldik/Taxkorgan complex. (C) 2017 Elsevier B.V. All rights reserved.

Titin is a giant protein spanning from the Z-disk to the M-band of the cardiac sarcomere. In the I-band titin acts as a molecular spring, contributing to passive mechanical characteristics of the myocardium throughout a heartbeat. RNA Binding Motif Protein 20 (RBM20) is required for normal titin splicing, and its absence or altered function leads to greater expression of a very large, more compliant N2BA titin isoform in Rbm20 homozygous mice (Rbm20(Delta RRm)) compared to wild-type mice (WT) that almost exclusively express the stiffer N2B titin isoform. Prior studies using Rbm20(Delta RRm) animals have shown that increased titin compliance compromises muscle ultrastructure and attenuates the Frank-Starling relationship. Although previous computational simulations of muscle contraction suggested that increasing compliance of the sarcomere slows the rate of tension development and prolongs cross-bridge attachment, none of the reported effects of Rbm20(Delta RRm) on myocardial function have been attributed to changes in cross-bridge cycling kinetics. To test the relationship between increased sarcomere compliance and cross-bridge kinetics, we used stochastic length-perturbation analysis in Ca2+-activated, skinned papillary muscle strips from Rbrn20<^>R'Rm and WT mice. We found increasing titin compliance depressed maximal tension, decreased Ca2+-sensitivity of the tension-pCa relationship, and slowed myosin detachment rate in myocardium from Rbm20(Delta RRm) vs. WT mice. As sarcomere length increased from 1.9 to 2.2 mu m, length-dependent activation of contraction was eliminated in the Rbrn20<^>R'Rm myocardium, even though myosin MgADP release rate decreased similar to 20% to prolong strong cross-bridge binding at longer sarcomere length. These data suggest that increasing N2BA expression may alter cardiac performance in a length-dependent manner, showing greater deficits in tension production and slower cross-bridge kinetics at longer sarcomere length. This study also supports the idea that passive mechanical characteristics of the myocardium influence ensemble cross-bridge behavior and maintenance of tension generation throughout the sarcomere.

We discuss the detection in the Outer Solar System Origins Survey (OSSOS) of two objects in Neptune's distant 9:1 mean motion resonance at semimajor axis a approximate to 130 au. Both objects are securely resonant on 10 Myr timescales, with one securely in the 9:1 resonance's leading asymmetric libration island and the other in either the symmetric or trailing asymmetric island. These objects are the largest semimajor axis objects with secure resonant classifications, and their detection in a carefully characterized survey allows for the first robust resonance population estimate beyond 100 au. The detection of these objects implies a 9:1 resonance population of 1.1 x 10(4) objects with H-r < 8.66 (D greater than or similar to 100 km) on Ksimilar orbits (95% confidence range of similar to(0.4-3) x 104). Integrations over4 Gyr of an ensemble of clones spanning these objects' orbit-fit uncertainties reveal that they both have median resonance occupation timescales of similar to 1 Gyr. These timescales are consistent with the hypothesis that these objects originate in the scattering population but became transiently stuck to Neptune's 9:1 resonance within the last similar to 1 Gyr of solar system evolution. Based on simulations of a model of the current scattering population, we estimate the expected resonance sticking population in the 9:1 resonance to be 1000-4500 objects with H-r < 8.66; this is marginally consistent with the OSSOS 9:1 population estimate. We conclude that resonance sticking is a plausible explanation for the observed 9:1 population, but we also discuss the possibility of a primordial 9:1 population, which would have interesting implications for the Kuiper Belt's dynamical his tory.

We investigate the crustal magnetic signatures of lunar craters using Lunar Prospector (LP) electron reflectometer data. Craters of all ages often have associated magnetic lows, showing that crustal fields were present even in pre-Nectarian times (≳3.9 Ga). Magnetic lows extend to ∼2–4 crater radii, suggesting shock rather than thermal demagnetization. Younger craters are more likely to have clear and complete demagnetization signatures, suggesting that many older magnetic lows have been subsequently obscured. No size dependence is found for craters larger than 50 km in diameter, suggesting that demagnetization effects for all craters in this size range completely penetrate the magnetized layer. If shock demagnetization is responsible, this suggests an upper limit of ∼50 km for the depth of magnetization. Evidence of edge effects due to magnetization contrasts may show that strong far-side crustal fields are coherent at scales of ∼25 km.