• Applications of iQID Cameras

      Han, Ling; Miller, Brian W.; Barrett, Harrison H.; Barber, H. Bradford; Furenlid, Lars R.; Univ Arizona, Coll Opt Sci; Univ Arizona, CGRI, Dept Med Imaging (SPIE-INT SOC OPTICAL ENGINEERING, 2017)
      iQID is an intensified quantum imaging detector developed in the Center for Gamma-Ray Imaging (CGRI). Originally called BazookaSPECT, iQID was designed for high-resolution gamma-ray imaging and preclinical gamma-ray single-photon emission computed tomography (SPECT). With the use of a columnar scintillator, an image intensifier and modern CCD/CMOS sensors, iQID cameras features outstanding intrinsic spatial resolution. In recent years, many advances have been achieved that greatly boost the performance of iQID, broadening its applications to cover nuclear and particle imaging for preclinical, clinical and homeland security settings. This paper presents an overview of the recent advances of iQID technology and its applications in preclinical and clinical scintigraphy, preclinical SPECT, particle imaging (alpha, neutron, beta, and fission fragment), and digital autoradiography.
    • A framework for optimizing micro-CT in dual-modality micro-CT/XFCT small-animal imaging system

      Vedantham, Srinivasan; Shrestha, Suman; Karellas, Andrew; Cho, Sang Hyun; Univ Arizona, Dept Med Imaging (SPIE-INT SOC OPTICAL ENGINEERING, 2017)
      Dual-modality Computed Tomography (CT)/X-ray Fluorescence Computed Tomography (XFCT) can be a valuable tool for imaging and quantifying the organ and tissue distribution of small concentrations of high atomic number materials in small-animal system. In this work, the framework for optimizing the micro-CT imaging system component of the dual modality system is described, either when the micro-CT images are concurrently acquired with XFCT and using the x-ray spectral conditions for XFCT, or when the micro-CT images are acquired sequentially and independently of XFCT. This framework utilizes the cascaded systems analysis for task-specific determination of the detectability index using numerical observer models at a given radiation dose, where the radiation dose is determined using Monte Carlo simulations.
    • Scintillator performance considerations for dedicated breast computed tomography

      Vedantham, Srinivasan; Shi, Linxi; Karellas, Andrew; Univ Arizona, Dept Med Imaging (SPIE-INT SOC OPTICAL ENGINEERING, 2017)
      Dedicated breast computed tomography (BCT) is an emerging clinical modality that can eliminate tissue superposition and has the potential for improved sensitivity and specificity for breast cancer detection and diagnosis. It is performed without physical compression of the breast. Most of the dedicated BCT systems use large-area detectors operating in cone-beam geometry and are referred to as cone-beam breast CT (CBBCT) systems. The large-area detectors in CBBCT systems are energy-integrating, indirect-type detectors employing a scintillator that converts x-ray photons to light, followed by detection of optical photons. A key consideration that determines the image quality achieved by such CBBCT systems is the choice of scintillator and its performance characteristics. In this work, a framework for analyzing the impact of the scintillator on CBBCT performance and its use for task-specific optimization of CBBCT imaging performance is described.