• An Extensive Set of Kinematic and Kinetic Data for Individuals with Intact Limbs and Transfemoral Prosthesis Users

      Fakoorian, S.; Roshanineshat, A.; Khalaf, P.; Azimi, V.; Simon, D.; Hardin, E.; Department of Electrical Engineering and Computer Engineering, University of Arizona (Hindawi Limited, 2020)
      This paper introduces an extensive human motion data set for typical activities of daily living. These data are crucial for the design and control of prosthetic devices for transfemoral prosthesis users. This data set was collected from seven individuals, including five individuals with intact limbs and two transfemoral prosthesis users. These data include the following types of movements: (1) walking at three different speeds; (2) walking up and down a 5-degree ramp; (3) stepping up and down; (4) sitting down and standing up. We provide full-body marker trajectories and ground reaction forces (GRFs) as well as joint angles, joint velocities, joint torques, and joint powers. This data set is publicly available at the website referenced in this paper. Data from flexion and extension of the hip, knee, and ankle are presented in this paper. However, the data accompanying this paper (available on the internet) include 46 distinct measurements and can be useful for validating or generating mathematical models to simulate the gait of both transfemoral prosthesis users and individuals with intact legs. © 2020 Seyed Fakoorian et al.
    • Case Report of a Rare Nonpuerperal Uterine Inversion Managed with Uterosacral Ligament Hysteropexy

      Azadi, A.; Wolfe, A.; Marchand, G.J.; University of Arizona, College of Medicine (Hindawi Limited, 2021)
      Nonpuerperal uterine inversions are rare. Typically occurring in older women, they are most commonly due to transcervical mass expulsion. Diagnosis is often difficult because of vague symptomatology, presentation, and unknown course of the pathology. Surgical correction is often necessary in the presence of active bleeding or prolapse severity causing urinary retention. This case of nonpuerperal inversion presented to the emergency department with vaginal bleeding and mass protrusion. The examination was consistent with POPQ stage IV prolapse and uterine inversion secondary to cervical expulsion of multiple uterine fibroids. Because of full cervical dilation and concerns of ureteral injury with an extirpative procedure, vaginal myomectomy was performed with concomitant robotic uterosacral ligament hysteropexy. The operative procedure and postoperative course were uncomplicated, and discharge occurred on post-op day 1. She remained asymptomatic at the 6-month follow-up encounter. Though uterine preservation has been performed in cases of uterine inversion to maintain fertility, there are no reported cases of concomitant hysteropexy being completed for correction of POPQ stage IV prolapse simultaneously encountered. Additionally, the novel robotic approach has not been documented. This case illustrates the short-term success of robotic uterosacral hysteropexy as an additional option of care with potentially less morbidity when compared to hysterectomy for advanced stage uterine prolapse with nonpuerperal uterine inversion. © 2021 Ali Azadi et al.
    • Change Detection and Feature Extraction of Debris-Flow Initiation by Rock-Slope Failure Using Point Cloud Processing

      He, Xiaoying; Yu, Zeqing; Kemeny, John M.; Youberg, Ann; Wang, Yunkun; College of Engineering, University of Arizona; College of Science, University of Arizona (Hindawi Limited, 2021-01-11)
      Our understanding of debris-flow initiation by slope failure is restricted by the challenge of acquiring accurate geomorphic features of debris flows and the structural setting of the rock mass in the remote mountainous terrain. Point cloud data of debris flows in Sabino Canyon, Tucson, Arizona, July 2006, with initiation by joint-controlled rock slope were obtained using multitemporal LiDAR scanning. Topographic changes were detected by comparing historical LiDAR scanning data of this area since 2005 by adopting open-source CloudCompare software. The results showed persistent scour and erosion in the debris flows after 2006. Point cloud data of joint-controlled rock in the initiation zone were generated by the means of photogrammetry using Pix4D software. The joint planes, the dip direction and the dip value of the joint plane, the joint spacing, and the joint roughness were therefore acquired by point cloud processing. Our study contributes a foundation for analyzing the relationship between the rock features, the generation of slope failure, and the initiation of debris flows. © 2021 Xiaoying He et al.
    • Crucial Genes in Aortic Dissection Identified by Weighted Gene Coexpression Network Analysis

      Zhang, H.; Chen, T.; Zhang, Y.; Lin, J.; Zhao, W.; Shi, Y.; Lau, H.; Zhang, Y.; Yang, M.; Xu, C.; et al. (Hindawi Limited, 2022)
      Background. Aortic dissection (AD) is a lethal vascular disease with high mortality and morbidity. Though AD clinical pathology is well understood, its molecular mechanisms remain unclear. Specifically, gene expression profiling helps illustrate the potential mechanism of aortic dissection in terms of gene regulation and its modification by risk factors. This study was aimed at identifying the genes and molecular mechanisms in aortic dissection through bioinformatics analysis. Method. Nine patients with AD and 10 healthy controls were enrolled. The gene expression in peripheral mononuclear cells was profiled through next-generation RNA sequencing. Analyses including differential expressed gene (DEG) via DEGseq, weighted gene coexpression network (WGCNA), and VisANT were performed to identify crucial genes associated with AD. The Database for Annotation, Visualization, and Integrated Discovery (DAVID) was also utilized to analyze Gene Ontology (GO). Results. DEG analysis revealed that 1,113 genes were associated with AD. Of these, 812 genes were markedly reduced, whereas 301 genes were highly expressed, in AD patients. DEGs were rich in certain categories such as MHC class II receptor activity, MHC class II protein complex, and immune response genes. Gene coexpression networks via WGCNA identified 3 gene hub modules, with one positively and 2 negatively correlated with AD, respectively. Specifically, module 37 was the most strongly positively correlated with AD with a correlation coefficient of 0.72. Within module 37, five hub genes (AGFG1, MCEMP1, IRAK3, KCNE1, and CLEC4D) displayed high connectivity and may have clinical significance in the pathogenesis of AD. Conclusion. Our analysis provides the possible association of specific genes and gene modules for the involvement of the immune system in aortic dissection. AGFG1, MCEMP1, IRAK3, KCNE1, and CLEC4D in module M37 were highly connected and strongly linked with AD, suggesting that these genes may help understand the pathogenesis of aortic dissection. © 2022 Hongliang Zhang et al.
    • Culture under Complex Perspective: A Classification for Traditional Chinese Cultural Elements Based on NLP and Complex Networks

      Qi, L.; Wang, Y.; Chen, J.; Liao, M.; Zhang, J.; Department of East Asian Studies, University of Arizona (Hindawi Limited, 2021)
      The cultural element is the minimum unit of a cultural system. The systematic categorizing, organizing, and retrieval of the traditional Chinese cultural elements are essential prerequisites for the realization of effective extracting and rational utilization, as well as the prerequisite for exploiting the contemporary value of the traditional Chinese culture. To build an objective, integrated, and reliable classification method and a system of traditional Chinese cultural elements, this study takes the text of Taiping Imperial Encyclopedia in Northern Song Dynasty as the primary data source. The unsupervised word segmentation methods are used to detect Out-of-Vocabulary (OOV), and then the segmentation results by the THULAC tool with and without custom dictionary are compared. The TF-IDF algorithm is applied to extract the keywords of cultural elements and the Ochiia coefficient is introduced to create complex networks of traditional Chinese cultural elements. After analyzing the topological characteristics of the network, the community detection algorithm is used to identify the topics of cultural elements. Finally, a "Means-Ends"two-dimensional orthogonal classification system is established to categorize the topics. The results showed that the degree distribution in the complex network of Chinese traditional cultural elements is a scale-free network with γ = 2.28. The network shows a structure of community and hierarchy features. The top 12 communities have taken up to 91.77% of the scale of the networks. Those 12 topics of the traditional Chinese cultural elements are circularly distributed in the orthogonal system of cultural elements' categorization. © 2021 Lin Qi et al.
    • Development of a Novel Algorithm to Identify People with High Likelihood of Adult Growth Hormone Deficiency in a US Healthcare Claims Database

      Yuen, K.C.J.; Birkegard, A.C.; Blevins, L.S.; Clemmons, D.R.; Hoffman, A.R.; Kelepouris, N.; Kerr, J.M.; Tarp, J.M.; Fleseriu, M.; University of Arizona, College Of Medicine (Hindawi Limited, 2022)
      Objective. Adult growth hormone deficiency (AGHD) is an underdiagnosed disease associated with increased morbidity and mortality. Identifying people who may benefit from growth hormone (GH) therapy can be challenging, as many AGHD symptoms resemble those of aging. We developed an algorithm to potentially help providers stratify people by their likelihood of having AGHD. Design. The algorithm was developed with, and applied to, data in the anonymized Truven Health MarketScan® claims database. Patients. A total of 135 million adults in the US aged ≥18 years with ≥6 months of data in the Truven database. Measurements. Proportion of people with high, moderate, or low likelihood of having AGHD, and differences in demographic and clinical characteristics among these groups. Results. Overall, 0.5%, 6.0%, and 93.6% of people were categorized into groups with high, moderate, or low likelihood of having AGHD, respectively. The proportions of females were 59.3%, 71.6%, and 50.4%, respectively. People in the high-and moderate-likelihood groups tended to be older than those in the low-likelihood group, with 58.3%, 49.0%, and 37.6% aged >50 years, respectively. Only 2.2% of people in the high-likelihood group received GH therapy as adults. The high-likelihood group had a higher incidence of comorbidities than the low-likelihood group, notably malignant neoplastic disease (standardized difference-0.42), malignant breast tumor (-0.27), hyperlipidemia (-0.26), hypertensive disorder (-0.25), osteoarthritis (-0.23), and heart disease (-0.22). Conclusions. This algorithm may represent a cost-effective approach to improve AGHD detection rates by identifying appropriate patients for further diagnostic testing and potential GH replacement treatment. © 2022 Kevin C. J. Yuen et al.
    • Epicardially Placed Bioengineered Cardiomyocyte Xenograft in Immune-Competent Rat Model of Heart Failure

      Chinyere, I.R.; Bradley, P.; Uhlorn, J.; Eason, J.; Mohran, S.; Repetti, G.G.; Daugherty, S.; Koevary, J.W.; Goldman, S.; Lancaster, J.J.; et al. (Hindawi Limited, 2021)
      Background. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are under preclinical investigation as a cell-based therapy for heart failure post-myocardial infarction. In a previous study, tissue-engineered cardiac grafts were found to improve hosts' cardiac electrical and mechanical functions. However, the durability of effect, immune response, and in vitro properties of the tissue graft remained uncharacterized. This present study is aimed at confirming the graft therapeutic efficacy in an immune-competent chronic heart failure (CHF) model and providing evaluation of the in vitro properties of the tissue graft. Methods. hiPSC-CMs and human dermal fibroblasts were cultured into a synthetic bioabsorbable scaffold. The engineered grafts underwent epicardial implantation in infarcted immune-competent male Sprague-Dawley rats. Plasma samples were collected throughout the study to quantify antibody titers. At the study endpoint, all cohorts underwent echocardiographic, hemodynamic, electrophysiologic, and histopathologic assessments. Results. The epicardially placed tissue graft therapy improved (p<0.05) in vivo and ex vivo cardiac function compared to the untreated CHF cohort. Total IgM and IgG increased for both the untreated and graft-treated CHF cohorts. An immune response to the grafts was detected after seven days in graft-treated CHF rats only. In vitro, engineered grafts exhibited responsiveness to beta-adrenergic receptor agonism/antagonism and SERCA inhibition and elicited complex molecular profiles. Conclusions. This hiPSC-CM-derived cardiac graft improved systolic and diastolic cardiac function in immune-competent CHF rats. The improvements were detectable at seven weeks post-graft implantation despite an antibody response beginning at week one and peaking at week three. This suggests that non-integrating cell-based therapy delivered by a bioengineered tissue graft for ischemic cardiomyopathy is a viable treatment option. © 2021 Ikeotunye Royal Chinyere et al.
    • Project Executive's Ethical Leadership and Construction Projects' Social Responsibility: Evidence from Wuhan, China

      Li, J.; Ying, W.; Xiong, R.; Ying, C.; Statistics and Data Science, University of Arizona (Hindawi Limited, 2022)
      With the accelerated urbanization and the need for sustainable development in China, the construction projects' social responsibility (CPSR) has received increasing attention from scholars, but reliable empirical evidence on whether the project executive's (PE's) ethical leadership can promote the implementation of the CPSR is insufficient. This study constructs a moderated mediation model in which we examine the role of employees' organizational identification and organizational justice in the relationship between the PE's ethical leadership and the organizational CPSR through data of 367 samples collected validly. Through the research, we found that the PE's ethical leadership has a positive impact on the CPSR, the employee's organizational identification mediates the relationship between the PE's ethical leadership and the organizational CPSR, and organizational justice moderates between the PE's ethical leadership and employee's organizational identification. The outcomes indicate that the PE's ethical leadership can promote the implementation of the organizational CPSR. This study reveals the intrinsic action mechanism of the PE's ethical leadership and the implementation of the organizational CPSR, which has certain implications for improving the performance of CPSR and achieving the sustainable development of the projects. © 2022 Jintao Li et al.
    • Repair of Posterior Vaginal Wall Defect Using Biologic Graft for Stage III-POP-Q Pelvic Organ Prolapse in a Patient with History of a J-Pouch

      Azadi, A.; Casey, S.; Ramanujam, P.; Tehranchi, D.; Ostergard, D.; University of Arizona, College of Medicine (Hindawi Limited, 2020)
      Surgical correction is considered in women with symptomatic pelvic organ prolapse (POP). There is an expected increase in the prevalence of surgical correction due to an aging population within the United States. Individuals with previous colorectal surgery present a unique challenge considering the changes in pelvic anatomy. This case discusses the challenges of posterior colporrhaphy in a patient with previous, remote J-pouch surgery. In traditional posterior colporrhaphy, randomized controlled trials have not shown any benefit of graft augmentation (Maher, 2016). However, the utilization of a biologic graft to improve anatomical correction is discussed in this unique case. Short term anatomical success was obtained without immediate complications in the postoperative period. In a patient with a history of ulcerative colitis with colorectal resection and a J-pouch, surgery can be challenging due to alterations of pelvic anatomy. Modification of the standard surgical approach may be required to achieve success. Copyright © 2020 Ali Azadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.