Among patients with chronic heart failure (HF) intravascular volume profiles vary significantly despite similar clinical compensation. However, little is known regarding changes in blood volume (BV) profiles over time. The objective of this analysis was to identify the extent and character of changes in volume profiles over time. A prospective analysis was undertaken in patients who were hospitalized and treated for fluid overload. Quantitative BV analyses were obtained in a compensated state at hospital discharge (baseline) and follow-up at 1, 3, and 6 mo. Data were available on 10 patients who remained stable without rehospitalization or medication change over a 6-mo period. Baseline BV profiles were highly variable at hospital discharge with an average deviation of +28% above normal in 6 patients and normal BV in 4 patients. Over the follow-up period, the median change in BV was -201 mL [-3% (-6, +3%)] from baseline with profiles remaining in the same volume category in 9 out of 10 patients. Crossover from normal BV to mild contraction (-13% of normal) occurred in one patient. Red blood cell mass demonstrated the largest change over 6 mo [median -275 (-410, +175) mL] with a deviation from normal of -14 (-20, +8) % (reflecting mild anemia). These findings suggest that BV profiles in clinically compensated patients with HF do not change substantially over a 6-mo period regardless of baseline expanded or normal BV. This lack of change in volume profiles particularly from an expanded BV has implications for long-term volume management, clinical outcomes, and also our understanding of volume homeostasis in HF.NEW & NOTEWORTHY The novel findings of this study demonstrate that blood volume profiles while highly variable in clinically compensated patients with HF on stable medical therapy do not change substantially over a 6-mo period regardless of baseline expanded or normal blood volumes. This lack of change in volume profiles particularly from an expanded blood volume has implications for long-term volume management and also for how we understand the pathophysiology of volume homeostasis in chronic HF.

An innovative single-layer, differentially-fed tri-band filtenna is presented. It is formed with a main patch, which consists of two interdigitated-coupled driven patches that are approximately mirror-symmetric, and four parasitic patches. The strong coupling between the two driven patches facilitates excitation of the TM1,0, TM1,2, TM1,4, and antiphase TM2,0 modes of the entire main patch and the consequent very small electrical size of the filtenna. Two pairs of open-ended branches are loaded on the main patch to improve the selectivity of the middle band. A pair of split-ring slots are etched on the main patch and four parasitic shorted patches are loaded near it to introduce additional in-band resonances and out-of-band radiation nulls simultaneously, which improve the bandwidth and selectivity of the lower and higher bands, respectively. A prototype was fabricated, assembled, and tested. Its electrical size is 0.31λL×0.28λL×0.031λL, λL being the free-space wavelength corresponding to the lower band’s center frequency. The experimental results, in agreement with their simulated values, demonstrate operation in three bands: 2.4–2.487, 3.72–3.93, and 5.57–5.88 GHz, with uniform polarization and similar broadside radiation performance. They also show excellent low cross-polarization levels, high common-mode noise immunity, and good filter properties over all three bands.

We study the importance of few-nucleon forces in chiral effective field theory for describing many-nucleon systems. A combinatorial argument suggests that three-nucleon forces-which are conventionally regarded as next-to-next-to-leading order-should accompany the two-nucleon force already at leading order (LO) starting with mass number A≃ 10–20. We find that this promotion enables the first realistic description of the 16 O ground state based on a renormalization-group-invariant LO interaction. We also performed coupled-cluster calculations of the equation of state for symmetric nuclear matter and our results indicate that LO four-nucleon forces could play a crucial role for describing heavy-mass nuclei. The enhancement mechanism we found is very general and could be important also in other many-body problems.

Phthalates are compounds used in consumer and medical products worldwide. Phthalate exposure in women has been demonstrated by detection of phthalate metabolites in their urine and ovarian follicular fluid. High urinary phthalate burden has been associated with reduced ovarian reserve and oocyte retrieval in women undergoing assisted reproduction. Unfortunately, no mechanistic explanation for these associations is available. In short term in vivo and in vitro animal studies modeling human-relevant exposures to di-n-butyl phthalate (DBP), we have identified ovarian folliculogenesis as a target for phthalate exposures. In the present study, we investigated whether DBP exposure negatively influences insulin-like growth factor 1 (IGF1) signaling in the ovary and disrupts ovarian folliculogenesis. CD-1 female mice were exposed to corn oil (vehicle) or DBP (10 µg/kg/day, 100 µg/kg/day, or 1000 mg/kg/day) for 20-32 days. Ovaries were collected as animals reached the proestrus stage to achieve estrous cycle synchronization. Levels of mRNAs encoding IGF1 and 2 (Igf1 and Igf2), IGF1 receptor (Igf1r), and IGF-binding proteins 1-6 (Ifgbp1-6) were measured in whole ovary homogenates. Ovarian follicle counts and immunostaining for phosphorylated IGF1R protein (pIGF1R) were used to evaluate folliculogenesis and IGF1R activation, respectively. DBP exposure, at a realistic dose that some women may experience (100 µg/kg/day for 20-32 days), reduced ovarian Igf1 and Igf1r mRNA expression and reduced small ovarian follicle numbers and primary follicle pIGF1R positivity in DBP-treated mice. These findings reveal that DBP tampers with the ovarian IGF1 system and provide molecular insight into how phthalates could influence the ovarian reserve in females.

Digital imaging has provided scientists with new opportunities to acquire and manipulate data using techniques that were difficult or impossible to employ in the past. Because digital images are easier to manipulate than film images, new problems have emerged. One growing concern in the scientific community is that digital images are not being handled with sufficient care. The problem is twofold: (1) the very small, yet troubling, number of intentional falsifications that have been identified, and (2) the more common unintentional, inappropriate manipulation of images for publication. Journals and professional societies have begun to address the issue with specific digital imaging guidelines. Unfortunately, the guidelines provided often do not come with instructions to explain their importance. Thus they deal with what should or should not be done, but not the associated ‘why’ that is required for understanding the rules. This article proposes 12 guidelines for scientific digital image manipulation and discusses the technical reasons behind these guidelines. These guidelines can be incorporated into lab meetings and graduate student training in order to provoke discussion and begin to bring an end to the culture of ‘‘data beautification’’.

Water management strategies are critical in regulating nitrous oxide (N2O) emissions from paddy soils under rice cultivation. Biochar is widely used as an amendment to decrease soil N2O emissions. However, the impacts of biochar amendment on N2O emissions under different water management strategies in paddy soils have not been investigated thoroughly, and the underlying mechanisms remain poorly understood. In particular, the effects of mid-season water drainage, a strategy used for water conservation, need to be better understood. In this study, a pot experiment was conducted including six treatments: alternating dry-wet conditions during the mid-season period without and with 2% (w/w) biochar (AWD1 and AWD2, respectively), continuous flooding during the mid-season period without (CF1) and with 2% (CF2) biochar, and regular mid-season drainage during the mid-season period without (CON1) and with 2% (CON2) biochar. All treatments received inorganic nitrogen, phosphorus and potassium fertilizers (NPK) administered in a split application. We found that fluxes of N2O emission peaked after the two fertilizers’ additions. No significant difference in the first N2O flux peak was found among different treatments. There also was no difference in the second N2O flux peak in both CF treatments, whereas biochar addition significantly decreased the second N2O flux peak in AWD2 and CON2 treatments. This was mainly due to increased nosZ gene copies and decreased ratios of denitrification and amoA genes to nosZ gene copies. Biochar amendments resulted in significant stimulation of nifH gene copies in the AWD2 treatment. Lastly, biochar increased rice yields in all treatments. Our study suggested that AWD2 was the optimal management strategy for mitigating N2O emissions and improving rice production in this tropical paddy soil.

Central-place foragers must learn the resource and visual landscapes around them when they are in a new environment, to facilitate efficient foraging and navigation. We investigated how the colony-level exploration strategy of Temnothorax rugatulus ants changes over time. For this study, we introduced ants to a novel environment by placing them in a foraging arena and tracking their movements over 3 days for 5 h per day, prohibiting access to the arena at other times. To test whether any changes in movement behavior are due to chemical markings, we replaced the paper floor on the third day. We found that colony-level exploration activity decreased with time, but only within a roughly 1 m radius around the nest, possibly reflecting a shift from familiarization or marking walks to searching. Individuals’ movements overall also became slightly straighter and faster across and within days. However, unlike learning walks of other ant species, T. rugatulus ants did not pause more often when facing toward the nest. Reactions to chemical markings seem to play a minor role in our observed effects, as the exploratory behavior did not reset after the floor cover had been replaced. Thus, ant colony exploration and search behaviors adapt to the familiarity of their environment by becoming more dispersive, possibly aiding in search efficiency. This must be considered in lab studies on the foraging activity and behavior of ants.

Modern high-performance computing (HPC) system designs have converged to heavyweight nodes with growing numbers of processors. If schedulers on these systems allocate nodes in an exclusive and dedicated manner, many HPC applications and scientific workflows will be unable to fully utilize and benefit from such hardware. This is because at such extreme scale, it will be difficult for modern HPC applications to utilize all of the node-level resources on these systems. In this paper, we investigate the potential of moving away from dedicated node allocation and instead using intelligent coscheduling—where multiple jobs can share node-level resources—to improve node utilization and therefore job turnaround time. We design and implement a coscheduling simulator, and, using traces from a high-end HPC cluster with 100K jobs and 1158 nodes, demonstrate that coscheduling can improve average turnaround times by up to 18% when compared to easy backfilling. Our results indicate that coscheduling has the potential to be a more efficient way to schedule jobs on high-end machines in both turnaround time and system and component utilization. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

This study examines the factors that affect Türkiye’s outward foreign direct investment (TODI) in European Union (EU) countries across quantiles using a panel quantile regression to understand the factors that affect TODI in EU countries with the most and least direct investment from Türkiye. We document that determinants of TODI in EU countries show significant discrepancies across quantiles. Mainly, we find that the relationship between the political stability (PS) level in EU countries and TODI is positive and also stable across quantiles. We also see a strong positive and monotonically declining relationship between Türkiye’s trade exports (EXP) and TODI. On the other hand, we do find that host country market size is negatively related to TODI with a declining slope across quantiles while labour resource endowments are positively related with a small variance across quantile. Overall, we provide policymakers with further information about the growing level of TODI in EU countries. Mainly, we recommend policy makers to make effective use of the relevant trade facilitation clauses in the EU customs union, expand the scale of Türkiye’s trade exports to EU countries, deepen political relations, and strengthen reciprocal political trust.

We uncover a seemingly previously unnoticed algebraic structure of a large class of reaction–diffusion equations and use it to study the long time behavior of the solutions and their convergence to traveling waves in the pulled and pushed regimes, as well as at the pushmi-pullyu boundary. One such new object introduced in this paper is the shape defect function, which, indirectly, measures the difference between the profiles of the solution and the traveling wave. While one can recast the classical notion of ‘steepness’ in terms of the positivity of the shape defect function, its positivity can, surprisingly, be used in numerous quantitative ways. In particular, the positivity is used in a new weighted Hopf-Cole transform and in a relative entropy approach that play a key role in the stability arguments. The shape defect function also gives a new connection between reaction–diffusion equations and reaction conservation laws at the pulled-pushed transition. Other simple but seemingly new algebraic constructions in the present paper supply various unexpected inequalities sprinkled throughout the paper. Of note is a new variational formulation that applies equally to pulled and pushed fronts, opening the door to an as-yet-elusive variational analysis in the pulled case.