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    Conjugation Studies: The Synthesis of Vinyl Aziridines through the aza-Darzens Reaction

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    Author
    Youtsler, Taylor Andrew
    Issue Date
    2015
    Keywords
    Aziridine
    Conjugation
    Imine
    Nucleophile
    Chemistry
    aza-Darzens
    Advisor
    Njarđarson, Jon T.
    
    Metadata
    Show full item record
    Publisher
    The University of Arizona.
    Rights
    Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
    Embargo
    10-Jul-2016
    Abstract
    Aziridines, three membered heterocycles containing a nitrogen in the ring, are extremely valuable to synthetic organic chemistry, as subjecting these compounds to ring opening processes initiates further capabilities for the molecule. Additionally, aziridines themselves possess the capacity and characteristics suitable for pharmaceutical applications, increasing the interest and appeal for their synthesis. One of the approaches to the formation of these products is the aza-Darzens reaction between imines and brominated nucleophiles. The research presented here aims to analyze this technique, specifically between tert-butanesulfinimines and methyl (E)-4-bromo-3-methylbut-2-enoate. Within the context of the reaction mechanism, the pivotal step involves nitrogen on a sulfinimine enolate bonding to the gamma carbon of the nucleophile, effectively cleaving bromine and producing an aziridine. Investigation into the development of the aforementioned imines and nucleophile is also accomplished in this undertaking.
    Type
    text
    Electronic Thesis
    Degree Name
    M.S.
    Degree Level
    masters
    Degree Program
    Graduate College
    Chemistry
    Degree Grantor
    University of Arizona
    Collections
    Master's Theses

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