Browsing Pharmacy Student Research Projects by Subjects
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Comparison of Content and Uniformity of American versus Mexican Manufactured Acyclovir and CephalexinObjectives: To determine whether acyclovir and cephalexin produced in Mexico are equivalent in content and uniformity to products made in the United States. Methods: High-pressure liquid chromatography (HPLC) assays were performed on drug samples of Mexican products and U.S. products using U.S. Pharmacopeia – National Formulary (USP-NF) guidelines.5 Content and content uniformity of the products from the U.S. and Mexico were compared. Results: Acyclovir produced in Mexico had 75.4% content and 78.1% content uniformity compared to the acyclovir produced in the United States. The Mexican manufactured cephalexin had 99.0% content and 99.9% content uniformity compared to the U.S. manufactured cephalexin. Implications: Not all Mexican manufactured drugs are equivalent in content and content uniformity to American manufactured drugs.