• Are Amphetamine/dextroamphetamine Doses Related to Prior History of Drug Abuse?

      Slack, Marion; Pourshams-Manzouri, Tania; Rahim, Hatef; College of Pharmacy, The University of Arizona (The University of Arizona., 2019)
      Specific Aims: The aim of this study was to see if there was a difference between the doses of amphetamine/dextroamphetamine being prescribed to patients that are using illicit substances. Methods: A retrospective cohort study was conducted to compare the dose of amphetamine/ dextroamphetamine of patients with an active prescription of amphetamine/dextroamphetamine with a history of substance abuse to the dose for patients with no history of substance abuse. The sample selection was collected from CODAC patients with an active prescription of amphetamine/ dextroamphetamine. A pool of 238 patients at CODAC were screened who had a history of substance abuse and prescribed amphetamine/ dextroamphetamine. A Chi Square test was used to determine if there was a difference between high and low doses of amphetamine/ dextroamphetamine and a history of substance abuse. High doses were between 20-30 mg per day and low doses were between 10-15 mg per day. The sample selection were currently admitted patients with an active prescription for amphetamine/dextroamphetamine. Main Results: Charts of 238 patients (mean age of 38.6; SD = 12.7) that were prescribed high doses of amphetamine/dextroamphetamine (20-30mg) at CODAC were reviewed. Of the total patient pool, 50.4% were female and 49.6% were male. Of the female patients, 56.6% of them had a history of substance abuse. Of the male patients, 71.2% of them had a history of substance abuse. Conclusions: Results indicate that patients with history of substance abuse may need high doses of amphetamine/dextroamphetamine.