• A Systematic Review of Alzheimer’s Disease Prevention with Diet

      Lee, Jeannie; Bhattacharjee, Sandipan; Martin, Jennifer; Robinson, Chris; Johnson, Mary; College of Pharmacy, The University of Arizona (The University of Arizona., 2018)
      Specific Aims: Examine the effects of the Mediterranean Diet as prevention of cognitive decline in older adults. Methods: We developed a systematic review searching ten different databases from inception of the database to March 2018. The database search provided 1,379 studies, of which five studies met the inclusion and exclusion criteria. Studies were included if there were no other modalities such as: physical activity, vitamins, minerals, and supplements. Main Results: The final five studies were either sub-analyses of randomized controlled trials or prospective cohort studies that included both males and females with an average age of 70.8 years old (range: 61.9 to 77.2 years-old) and an average follow-up of 4.6 years (range 2 to 6.6 years). The five studies reported profound differences in the risk of dementia among study participants. The consensus of the studies is that greater adherence to a Mediterranean Diet appears to influence prevention of cognitive decline. Even though the consensus is that a Mediterranean diet can prevent dementia, more research is needed to prove a stronger correlation. Conclusions: As a result of heterogeneous data, a meta-analysis of the five studies proved inconclusive. The five articles differed in outcomes related to Mediterranean Diet adherence, such as different Mediterranean diet groups with modified versions of the Mediterranean Diet or adherence to the Mediterranean diet using the validated Mediterranean Diet Score (MDS) point system classifying adherence based on low, medium, and high. Lastly, the studies differed in how they measured cognitive decline.