• Comparison of Vancomycin AUC Calculation Methods in Patients with Cystic Fibrosis

      Phan, Hanna; Matthias, Kathryn; Coulter, Josh; Hilde, Casey; College of Pharmacy, The University of Arizona (The University of Arizona., 2018)
      Specific Aims: Determine if there is clinical and statistical significance between using a predictor equation versus a 2S method of vancomycin monitoring in cystic fibrosis (CF) patients. Evaluate if there is a correlation between vancomycin trough values and AUC0-24/MIC in patients with CF. Methods: This study was a retrospective cohort study using patient charts using EPIC software provided from Banner-UMC. Demographic and vancomycin pharmacokinetic data was documented from patients with CF being treated for MRSA respiratory infections. Pharmacokinetic data was then used to calculate the AUC0-24/MIC using regular two level kinetics as well as three population-based pharmacokinetic equations to test their validity against regular kinetics. Main Results Conclusions