• Faculty Senate Minutes April 6, 2020

      University of Arizona Faculty Senate (Tucson, AZ), 2020-04-06
    • SPBAC Minutes April 1, 2020

      University of Arizona Strategic Planning and Budget Advisory Committee (SPBAC) (The University of Arizona (Tucson, AZ), 2020-04-01)
    • SPBAC Minutes March 18, 2020

      University of Arizona Strategic Planning and Budget Advisory Committee (SPBAC) (The University of Arizona (Tucson, AZ), 2020-03-18)
    • SPBAC Minutes March 4, 2020

      University of Arizona Strategic Planning and Budget Advisory Committee (SPBAC) (The University of Arizona (Tucson, AZ), 2020-03-04)
    • Faculty Senate Minutes March 2, 2020

      University of Arizona Faculty Senate (Tucson, AZ), 2020-03-02
    • SPBAC Minutes February 19, 2020

      University of Arizona Strategic Planning and Budget Advisory Committee (SPBAC) (The University of Arizona (Tucson, AZ), 2020-02-19)
    • SPBAC Minutes February 5, 2020

      University of Arizona Strategic Planning and Budget Advisory Committee (SPBAC) (The University of Arizona (Tucson, AZ), 2020-02-05)
    • Faculty Senate Minutes February 3, 2020

      University of Arizona Faculty Senate (Tucson, AZ), 2020-02-03
    • Is Cancer Diagnosis Really A "Teachable Moment" for Smoking Cessation?

      Burriss, Jessica L.; University of Kentucky (University of Arizona (Tucson, AZ), 2020-01-31)
      Most people assume cancer diagnosis functions as a “teachable moment,” that is, a major life event that triggers a significant increase in people’s motivation to adopt healthy behaviors (e.g., regular exercise, diet high in fresh fruits/veggies) and cease unhealthy behaviors (e.g., heavy alcohol use, medication noncompliance). Conceivably, the power of cancer diagnosis to serve as a “teachable moment” should extend to smoking behavior wherein cancer patients would be expected to quit smoking immediately upon diagnosis and remain abstinent for the balance of their lives. In reality, however, cancer survivors are estimated to smoke at a rate that is equal to or greater than the general population, with subgroups of cancer survivors smoking at much higher rates (40-50%). In my work, I aim to determine if, how, and for whom cancer diagnosis does indeed function as a “teachable moment” for smoking, with a central goal of more fully understanding the naturalistic process by which smoking cessation occurs after a new cancer diagnosis. In this talk, I will examine the interplay between cancer diagnosis and smoking behavior through several different, but complementary research methods, including intensive longitudinal data collection, concurrent mixed methods, randomized clinical trials, and implementation science. Ultimately, this line of research has the goal of promoting smoking cessation among the most vulnerable cancer survivors, including those who report little to no intention to quit and those who are faced with high levels of unmet social support needs.
    • SPBAC Minutes January 22, 2020

      University of Arizona Strategic Planning and Budget Advisory Committee (SPBAC) (The University of Arizona (Tucson, AZ), 2020-01-22)
    • Science Team Organization and Roster

      OSIRIS-REx Asteroid Sample Return Mission (2020)
    • An ecological snapshot of Clostridioides difficile: characterizing genetic diversity of C. difficile within Banner-University Medical Center Phoenix

      Brussels, Aaron; Vedantam, Gayatri (The University of Arizona., 2020)
      RATIONALE: The genetic diversity of Clostridioides difficile within hospitals is known to vary geographically: the C. difficile ecology within Banner-University Medical Center Phoenix (BUMCP) is uncharacterized. METHODS: A laboratory-based surveillance study design was used unique to-be-discarded stool samples testing positive for C. difficile infection (CDI) at BUMCP per their existing testing protocol were collected and banked over a 16 month period. Each deidentified sample underwent selection and culture before being prepared for and subjected to capillary PCR in order to determine genetic type (ribotype) of each offending strain of C. difficile. RESULTS: A total of 267 samples met inclusion criteria for this study; 225 were successfully genetically typed, and 83 unique ribotypes were identified. 17 ribotypes (20.5%) are responsible for 60.5% of all typeable cases of CDI during the study period, while 43 strains (51.8%) were each represented by only one case (15.1% of typeable cases) and another 23 strains (27.7%) were represented by two cases (20.4% of typable cases). CONCLUSIONS: There is an uneven distribution of disease burden relative to ribotype. This finding is consistent with similar investigations in other geographies. The highest burdens of disease are attributable to ribotypes 027, 106 and 176 – all well-documented hypervirulent outbreak associated strains.
    • 10-Year Epidemiology of Ankle Injuries in Men’s and Women’s Collegiate Soccer Players

      Gulbrandsen, Matt; Chhabra, Anikar (The University of Arizona., 2020)
      Background: Data from the National Collegiate Athletic Associ-ation (NCAA) Injury Surveillance Program (ISP) has indicated that ankle injuries are the most common injuries among NCAA soccer players. Objective:To review 10 years of NCAA-ISP data for soccer players’ ankle injuries to understand how the time period (2004-2005 through 2008-2009 versus 2009-2010 through 2013-2014), anatomical structure injured, and sex of the athlete affected the injury rate, mechanism, and prognoses. Design:Descriptive epidemiology study. Setting: Online injury surveillance. Main Outcome Measure(s): The NCAA-ISP was queriedfor men’s and women’s soccer ankle data from 2004 to 2014. Ankle injury rates were calculated on the basis of injuries per 1000 athlete-exposures. Rate ratios (RRs) were used to compare injury rates. Injury proportion ratios (IPRs) were used to compare injury characteristics. Results: When compared with the 2004-2005 through 2008-2009 seasons, the 2009-2010 through 2013-2014 seasons showed a similar rate of injuries (RR¼0.94, 95% confidence interval [CI]¼0.85, 1.04) but fewer days missed (P,.001) and fewer recurrent injuries (IPR¼0.55, 95% CI¼0.41,0.74). The 4 most common ankle injuries, which accounted for 95% of ankle injuries, were lateral ligament complex tears(65.67%), tibiofibular ligament (high ankle) sprains (10.3%), contusions (10.1%), and medial (deltoid) ligament tears (9.77%). Of these injuries, high ankle sprains were most likely to cause athletes to miss 30þdays (IPR¼1.9, 95% CI¼1.24, 2.90). Men and women had similar injury rates (RR¼1.02, 95% CI¼0.94, 1.11). Men had more contact injuries (IPR¼1.28, 95% CI¼1.16, 1.41) and contusion injuries (IPR¼1.34, CI¼1.03, 1.73) but fewer noncontact injuries (IPR¼0.86, 95% CI¼0.78, 0.95) and lateral ligamentous complex injuries (IPR¼0.92, 95% CI¼0.86, 0.98). Conclusions: Although the rate of ankle injuries did not change between the 2004-2005 through 2008-2009 seasons and the 2009-2010 through 2013-2014 seasons, the prognoses improved. Among the 4 most common ankle injuries, high anklesprains resulted in the worst prognosis. Overall, male and female NCAA soccer players injured their ankles at similar rates; however, men were more likely to sustain contact injuries.
    • Trend Analysis of the Incidence of Certain Aesthetic Surgical Procedures in the United States within the Last 19 Years and the Influence of Changing Demographics

      Meza-Rochin, Ana; Bernard, Robert (The University of Arizona., 2020)
      Over the years, there has been an increase in the overall incidence of surgical cosmetic procedures performed in the United States and in some instances, a seemingly disproportionate increase in the incidence of certain procedures12. We believe that several factors, including, but not limited to changes in the U.S. demographics such as race, socioeconomic status and education level in minorities have influenced certain types of procedures performed. The procedures that we analyzed for this study were ethnic rhinoplasties, blepharoplasties, and buttock augmentations. To conduct this study, statistics for surgical aesthetic procedures were evaluated from 1997 to 2016. The total number of rhinoplasties, blepharoplasties and buttock augmentations per year were recorded on an excel table for all 19 years (1997-2016). Trend analysis was performed to assess possible reasons for changes overtime of the yearly incidence for each of the procedures studied. Various literature sources aided in deciphering the relationship between the incidence of certain aesthetic surgical procedures relating to changing demographics such as ethnicity, income, age, and other demographic factors.
    • Endoscopically Assisted Targeted Keyhole Retrosigmoid Approaches for Microvascular Decompression: Quantitative Anatomic Study

      Onaka, Naomi; Preul, Mark C. (The University of Arizona., 2020)
      OBJECTIVE: We describe and quantitatively assess minimally invasive keyhole retrosigmoid approaches targeted to the upper, middle, and lower cranial nerve (CN) complexes of the cerebellopontine angle (CPA). METHODS: Anatomic dissections were performed on 10 sides of 5 fixed, silicone-injected cadaver heads. Surgical views through various trajectories were assessed in endoscopic videos and 3-dimensional (3D) interactive virtual reality microscope views. Surgical freedom and angles of attack to the proximal and distal areas of CN complexes of the CPA were compared among upper and lower keyholes and conventional retrosigmoid craniotomy using neuronavigation. RESULTS: Compared with keyholes, the conventional approach had superior surgical freedom to most areas except for the distal CN V, the root of CN VII, and the root of CN IX, where differences were not significant. The conventional retrosigmoid approach provided a larger horizontal angle of attack than either the upper or lower keyholes for all selected areas; however, the vertical angles of attack were not different. Splitting the petrosal fissure resulted in a significant increase in the vertical angle of attack to the root zones of CNs V and VII but not to the distal areas of these nerves or CN IX. Illustrative cases of endoscope-assisted keyhole retrosigmoid approaches for the treatment of trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia are presented. - CONCLUSIONS: Targeted keyhole retrosigmoid approaches require detailed understanding of the 3D anatomy of the CPA to create appropriate locations of corridors, including skin incisions and keyholes. Endoscope assistance complements the standard microsurgical technique by maximizing the visualization and identification of the delicate neurovascular structures.
    • Cefazolin Monotherapy Versus Cefazolin Plus Aminoglycoside for Antimicrobial Prophylaxis of Type III Open Fractures

      Meshay, Ian; Culver, Mark (The University of Arizona., 2020)
      Background: There are conflicting recommendations between organizations regarding aminoglycoside use for the prophylaxis of type III open fractures. Study Question: To compare cefazolin monotherapy versus cefazolin plus aminoglycoside therapy for prophylaxis of type III open fractures in trauma patients. Study Design: This was a multicenter retrospective cohort study conducted in three academic medical centers in the United States. Consecutive adult trauma patients with type III open fractures between January 2014 and September 2016 were included. Patients were divided into two groups: 1) cefazolin monotherapy versus 2) cefazolin plus aminoglycoside. Measures and Outcomes: The primary outcome measure was occurrence of infection at the open fracture site. The secondary outcome measure was occurrence of acute kidney injury. Results: There were 134 patients included in the study cohort. Of these, 39 received cefazolin monotherapy and 95 received cefazolin plus aminoglycoside. Overall, the mean age was 39 ± 15 years, 105 (78%) were male, and the most common fracture location was tibia/fibula (n=74, 56%). Infection at the open fracture site occurred in 6/39 (15%) in the cefazolin monotherapy group and 15/95 (16%) in the cefazolin plus aminoglycoside group (p=1.000). Acute kidney injury occurred in 0/39 (0%) in the cefazolin monotherapy group and 1/95 (1%) in the cefazolin plus aminoglycoside group (p=1.000). Conclusion: Cefazolin monotherapy may be appropriate for antimicrobial prophylaxis of type III open fractures in trauma patients.
    • Ethical Guidelines for Human Subjects Research in Least Developed Countries: How do they compare to the Council for International Organizations of Medical Sciences International Ethical Guidelines?

      Reed, Melissa; Beyda, David (The University of Arizona., 2020)
      Background: The most vulnerable populations for human subjects research are those living in the most resource poor settings. As technology has progressed to support convenient long-distance travel, international communication, and data sharing via the internet, international research has become a more manageable task. While some dismiss the ethical guidelines for human subjects research as necessary only for the most barbaric researchers, history demonstrates the need for ethical guidelines as well as oversight of adherence to such guidelines. Methods: Forty-eight countries designated as least developed countries (LDCs) were identified and selected for analysis. An internet search was utilized to identify research guidelines for LDCs available online or primary research studies conducted in such countries to determine to what extent authors noted ethical considerations. Council for the International Organizations of Medical Sciences (CIOMS) guidelines were distilled into keywords by the authors and compared to guidelines for LDCs. Frequencies and percentages of comparison to CIOMS guidelines were tabulated across the 48 LDCs. Findings: Of the 48 LDCs identified, 22 did not have published research guidelines or mention of a Research Ethics Committee (REC). An additional 10 countries had documentation of some sort of REC, 3 countries had at least one ethical guideline in addition to a REC, and 13 countries had no mention of a REC but did have established ethical guidelines available online. Overall, the average number of guidelines per country was 5 with a SD of 4.11. Conclusion: Over half of countries had online documentation of limited ethics oversight for research, indicating a clear lack of thoroughness in the available guidelines as compared to the international gold standard guidelines from CIOMS. The majority of primary research articles reviewed showed no mention of ethical considerations despite some of the articles using chart review or engaging in patient care interventions. Based on the findings of this study, authors recommend the adoption of existing ethical guidelines by countries still lacking individualized guidelines, as well as a movement toward journals requiring documentation of ethical approval or ethical considerations as a requirement prior to approving articles for publication.
    • Prevalence of Sexually Transmitted Infections (STI’s) among Incoming Refugees in Maricopa County, Arizona

      Osman, Fawsia; Khurana, Renuka (The University of Arizona., 2020)
      Objective: The aim for this study was to determine the prevalence rate of Sexually Transmitted Infections (STI’S) among incoming refugees in Maricopa County in the state of Arizona. Design: A retrospective study Setting: Maricopa County Public Health Department Participants: 1,471 refugees from the Maricopa County Main outcome measures: Prevalence of Chlamydia, Gonorrhea, HIV and syphilis among incoming refugees compared to the Maricopa County prevalence. Results: The overall prevalence rates among those tested were 1.12% (90 of 8,055) for Chlamydia, 0.19% (15 of 8,055) for Gonorrhea, 0.73% (80 of 11,018) for HIV, and 55.5% (71of 138) for Syphilis (+TPPA+RPR). The prevalence rates of Chlamydia(p<0.001), HIV (p<0.001) and Syphilis (p<0.001) were statistically significant when compared to the Maricopa County rates while the rate of Gonorrhea (p<0.84) did not show statistical difference. There was no statistically significant difference noted in the all the STI’s tested among males and females. Between the various age groups, Chlamydia was statistically higher among the age group of 15- 25 p<0.04 while HIV was statistically significant among the age group of 36-45 p<0.04. Among the different regions, syphilis, the seroprevalence rate was highest among those from the Caribbean (73.7%) p<0.02 than among persons from the other three region (South/southeast Asia, Sub-Saharan Africa, Middle East and North Africa). Chlamydia had the highest prevalence among those from the Middle East/ North Africa (2.0%) p<0.04. There was no statistically significant among the prevalence of Chlamydia, Gonorrhea, HIV and Syphilis and HIV over the years from 2013-2017. Conclusion: Overall, the higher prevalence rates of Chlamydia, HIV and Syphilis when compared to the population they immigrate into indicate the importance of routine screening of incoming refuges and utility of CDC refugee post-arrival screening and evaluation recommendations.
    • Effects of a workplace sedentary behavior intervention on sleep in office workers with sleep complaints: Results from the Stand and Move at Work Trial

      Schaeffler, Kelby; Buman, Matthew (The University of Arizona., 2020)
      Background: Chronic inadequate sleep is associated with increased risk for cardiovascular disease, hypertension, obesity, immunosuppression and overall mortality. There is an abundance of research on the effects of exercise on sleep, but there is currently no data on the impact of sedentary interventions in the workplace on acute and long-term sleep quality/quantity. Purpose: The purpose of this study is to determine if increased standing and/or light-intensity physical activity (LPA) at work will improve sleep quality and duration in sedentary office-workers with mild to moderate sleep complaints. Methods: For this group randomized trial, 51 participants with mild-to-moderate sleep complaints were selected from the Stand and Move at Work Trial. Participants were randomized into two groups: MOVE+ (a multilevel individual, social, environmental, and organizational intervention targeting increases in LPA in the workplace) and STAND+ (MOVE+ intervention with the addition of the installation of sit-stand workstations). Sedentary behavior/LPA and sleep were measured objectively at baseline, 3 and 12 months with the activPAL3 micro accelerometer (PAL Technologies, Glasgow, United Kingdom) and the GeneActiv (GeneActiv, Activinsight, Wimbolton, UK) wrist-worn actigraphy sensor. Results: The sit-stand workstation intervention was effective, with the STAND+ participants sitting on average 70 minutes/day less than the MOVE+ participants at 12 months (p<0.05). There were no statistically significant differences between intervention groups in objectively or subjectively measured time in bed, total sleep time, sleep onset latency, wake after sleep onset, or sleep efficiency at the 3 or 12-month timepoints. On the individual level, adjusting for group assignment, there was no correlation between change in sedentary behavior and sleep measures, objective or subjective. Conclusion: This study found no correlation between a decrease in sedentary behavior at work and changes in objective or subjective measures of sleep. Limitations of this study include underpowering due to small sample size, potential significance of difference in baseline demographics and sleep/sedentary behavior between in groups, and the nature of the intervention being low-dose.
    • Lesion Size as a Predictor of Non-Operative Therapy Failure in Juvenile Osteochondritis Dissecans of the Knee

      Roehr, Mark; Kelly, Brian (The University of Arizona., 2020)
      Background: The primary challenge in juvenile osteochondritis dissecans of the knee management lies in the lack of definitive non-operative treatment criteria. The purpose of this study was to evaluate the predictive nature of the lesion size and to determine a lesion size cutoff point beyond which a patient’s likelihood of successful 3 month non-operative therapy significantly declines. Methods: 36 knees were retrospectively identified that met the inclusion criteria of stable JOCD lesions that received a 3 month non-operative therapy treatment consisting of either unloader bracing and/or activity restriction. The primary outcome of interest was improved clinical status at three months with accompanying MRI evidence of reossification. Continuous and categorical variables including lesion size were analyzed using logistic regression to ascertain the likelihood of a surgical intervention following a non-operative treatment regimen. Results: Following three months of non-operative treatment, 23 of the 36 knees (64%) had progression toward healing. The mean starting age of the patients with lesions that progressed toward healing was 10.4 years +/- 2.10 years and the mean age that required surgical referral was 12.4 years +/- 1.18 years (p = 0.002). The mean surface area of the lesions that demonstrated progression toward healing was 185.0mm2 +/- 103.7mm2, and the mean surface area of the lesions that did not progress toward healing and were referred for surgical management was 266.6mm2 +/- 95.5mm2 (p = 0.01). The mean lesion surface area cut point >250mm2 contained 13 knees. Of these 13 knees, 4 progressed toward healing (17.4% of the healing group), while 9 required surgical referral (69.2% of the surgery group) (OR = 6.84, 95% CI [1.17,39.8], p = 0.032). Conclusion: Increased lesion size and increased age were the strongest predictors of JOCD non-operative therapy failure. Stable lesions with a mean surface area that is > 250mm2 are at an increased risk for non-opperative failure and should be considered for direct surgical referral on a case by case basis.