Early Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling.
AuthorMoore-Dotson, Johnnie M.
Beckman, Jamie J.
Mazade, Reece E.
Bernstein, Adam S.
Romero-Aleshire, Melissa J.
Brooks, Heddwen L.
Eggers, Erika D.
AffiliationDepartment of Physiology, University of Arizona
Graduate Interdisciplinary Program in Physiological Sciences, University of Arizona
Department of Biomedical Engineering, University of Arizona
MetadataShow full item record
CitationEarly Retinal Neuronal Dysfunction in Diabetic Mice: Reduced Light-Evoked Inhibition Increases Rod Pathway Signaling. 2016, 57 (3):1418-30 Invest. Ophthalmol. Vis. Sci.
RightsArchived with thanks to Investigative ophthalmology & visual science
AbstractRecent studies suggest that the neural retinal response to light is compromised in diabetes. Electroretinogram studies suggest that the dim light retinal rod pathway is especially susceptible to diabetic damage. The purpose of this study was to determine whether diabetes alters rod pathway signaling.
The following license files are associated with this item:
- GABA(A), GABA(C) and glycine receptor-mediated inhibition differentially affects light-evoked signalling from mouse retinal rod bipolar cells.
- Authors: Eggers ED, Lukasiewicz PD
- Issue date: 2006 Apr 1
- Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus.
- Authors: Castilho Á, Ambrósio AF, Hartveit E, Veruki ML
- Issue date: 2015 Apr 1
- Light adaptation alters the source of inhibition to the mouse retinal OFF pathway.
- Authors: Mazade RE, Eggers ED
- Issue date: 2013 Nov
- Inhibition to retinal rod bipolar cells is regulated by light levels.
- Authors: Eggers ED, Mazade RE, Klein JS
- Issue date: 2013 Jul
- Voltage-gated Na channels in AII amacrine cells accelerate scotopic light responses mediated by the rod bipolar cell pathway.
- Authors: Tian M, Jarsky T, Murphy GJ, Rieke F, Singer JH
- Issue date: 2010 Mar 31