Dominance of multidrug resistant CC271 clones in macrolide-resistant Streptococcus pneumoniae in Arizona
Author
Bowers, JoleneDriebe, Elizabeth
Nibecker, Jennifer
Wojack, Bette
Sarovich, Derek
Wong, Ada
Brzoska, Pius
Hubert, Nathaniel
Knadler, Andrew
Watson, Lindsey
Wagner, David
Furtado, Manohar
Saubolle, Michael
Engelthaler, David
Keim, Paul
Affiliation
Translational Genomics Research Institute, Flagstaff, AZ, USALaboratory Sciences of Arizona, Tempe, AZ, USA
Northern Arizona University, Flagstaff, AZ, USA
Life Technologies, Foster City, CA, USA
University of Arizona, Tucson, AZ, USA
Issue Date
2012
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BioMed CentralCitation
Bowers et al. BMC Microbiology 2012, 12:12 http://www.biomedcentral.com/1471-2180/12/12Journal
BMC MicrobiologyRights
© 2012 Bowers et al; BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).Collection Information
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.Abstract
BACKGROUND:Rates of resistance to macrolide antibiotics in Streptococcus pneumoniae are rising around the world due to the spread of mobile genetic elements harboring mef(E) and erm(B) genes and post-vaccine clonal expansion of strains that carry them.RESULTS:Characterization of 592 clinical isolates collected in Arizona over a 10 year period shows 23.6% are macrolide resistant. The largest portion of the macrolide-resistant population, 52%, is dual mef(E)/erm(B)-positive. All dual-positive isolates are multidrug-resistant clonal lineages of Taiwan19F-14, mostly multilocus sequence type 320, carrying the recently described transposon Tn2010. The remainder of the macrolide resistant S. pneumoniae collection includes 31% mef(E)-positive, and 9% erm(B)-positive strains.CONCLUSIONS:The dual-positive, multidrug-resistant S. pneumoniae clones have likely expanded by switching to non-vaccine serotypes after the heptavalent pneumococcal conjugate vaccine release, and their success limits therapy options. This upsurge could have a considerable clinical impact in Arizona.EISSN
1471-2180Version
Final published versionAdditional Links
http://www.biomedcentral.com/1471-2180/12/12ae974a485f413a2113503eed53cd6c53
10.1186/1471-2180-12-12
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Except where otherwise noted, this item's license is described as © 2012 Bowers et al; BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).