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    Macrophage migration inhibitory factor: controller of systemic inflammation

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    Author
    Larson, Douglas
    Horak, Katherine
    Affiliation
    Sarver Heart Center and Departments of Surgery and Medical Pharmacology, College of Medicine, The University of Arizona, Tucson, Arizona, USA
    Issue Date
    2006
    
    Metadata
    Show full item record
    Publisher
    BioMed Central
    Citation
    Critical Care 2006, 10:138 (doi:10.1186/cc4899)
    Journal
    Critical Care
    Rights
    © 2006 BioMed Central Ltd.
    Collection Information
    This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
    Abstract
    Macrophage migration inhibitory factor (MIF) is a cytokine that is secreted by the anterior pituitary and immune cells in response to surgical stress, injury, and sepsis. This cytokine appears to be a critical regulator of the inflammatory pathways, leading to systemic inflammatory response syndrome and subsequent multiple organ dysfunction syndrome. This report provides an integrated scheme describing the manner by which MIF controls the neurohormonal response and the adaptive immune system, namely the T-helper (Th)1 and Th2 lymphocytes, which results in the release of pro-inflammatory cytokines and the anti-inflammatory cytokine interleukin-10. The development of systemic inflammatory response syndrome and subsequent development of multiple organ dysfunction syndrome appear to be related to MIF levels and the balance of Th1 and Th2 function.
    EISSN
    1466-609X
    DOI
    10.1186/cc4899
    Version
    Final published version
    Additional Links
    http://ccforum.com/content/10/2/138
    ae974a485f413a2113503eed53cd6c53
    10.1186/cc4899
    Scopus Count
    Collections
    UA Faculty Publications

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