Endometrial Glandular Dysplasia (EmGD): morphologically and biologically distinctive putative precursor lesions of Type II endometrial cancers
Affiliation
Department of Pathology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Texas, USADepartment of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Department of Pathology, Department of Obstetrics and Gynecology, and the Arizona Cancer Center, University of Arizona College of Medicine, Tucson, Arizona, USA
Department of Pathology and Hospital of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China
Issue Date
2008
Metadata
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BioMed CentralCitation
Diagnostic Pathology 2008, 3:6 doi:10.1186/1746-1596-3-6Journal
Diagnostic PathologyRights
© 2008 Fadare and Zheng; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)Collection Information
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.Abstract
In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for the discontinuation of the term serous "endometrial intraepithelial carcinoma (EIC)" as a descriptor for a supposedly intraepithelial, precancerous lesion. Preliminary evidence is also presented that suggests that there is a morphologically recognizable "clear cell EmGD" that probably represents a precancerous lesion to endometrial clear cell carcinomas.EISSN
1746-1596Version
Final published versionAdditional Links
http://www.diagnosticpathology.org/content/3/1/6ae974a485f413a2113503eed53cd6c53
10.1186/1746-1596-3-6