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    Endometrial Glandular Dysplasia (EmGD): morphologically and biologically distinctive putative precursor lesions of Type II endometrial cancers

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    Author
    Fadare, Oluwole
    Zheng, Wenxin
    Affiliation
    Department of Pathology, Wilford Hall Medical Center, Lackland Air Force Base, San Antonio, Texas, USA
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Department of Pathology, Department of Obstetrics and Gynecology, and the Arizona Cancer Center, University of Arizona College of Medicine, Tucson, Arizona, USA
    Department of Pathology and Hospital of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China
    Issue Date
    2008
    
    Metadata
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    Publisher
    BioMed Central
    Citation
    Diagnostic Pathology 2008, 3:6 doi:10.1186/1746-1596-3-6
    Journal
    Diagnostic Pathology
    Rights
    © 2008 Fadare and Zheng; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
    Collection Information
    This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
    Abstract
    In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for the discontinuation of the term serous "endometrial intraepithelial carcinoma (EIC)" as a descriptor for a supposedly intraepithelial, precancerous lesion. Preliminary evidence is also presented that suggests that there is a morphologically recognizable "clear cell EmGD" that probably represents a precancerous lesion to endometrial clear cell carcinomas.
    EISSN
    1746-1596
    DOI
    10.1186/1746-1596-3-6
    Version
    Final published version
    Additional Links
    http://www.diagnosticpathology.org/content/3/1/6
    ae974a485f413a2113503eed53cd6c53
    10.1186/1746-1596-3-6
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