Persufflation (gaseous oxygen perfusion) as a method of heart preservation
Sutherland, David E. R.
AffiliationDivision of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, USA
Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA
Institute for Cellular Transplantation, Department of Surgery, University of Arizona, 1656 E. Mabel Street, Room 121, Tucson, AZ 85724, USA
Division of Cardiovascular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA
St. Josephs Translational Research Institute, Atlanta, GA, USA
Division of Cardiothoracic Surgery, Department of Surgery, University of Minnesota, Minneapolis, MN, USA
Giner Inc, Newton, MA, USA
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CitationSuszynski et al. Journal of Cardiothoracic Surgery 2013, 8:105 http://www.cardiothoracicsurgery.org/content/8/1/105
Rights© 2013 Suszynski et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
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AbstractPersufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggest that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.
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