Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis
AffiliationDepartment of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 W. Wenhua Road, Jinan, Shandong, China 250012
Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA
Department of Obstetrics and Gynecology, University of Arizona, Tucson, AZ, USA
Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
Department of Pathology, University of Arizona, 1501 N. Campbell Avenue, #5224A, Tucson, AZ 85724, USA
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CitationLi et al. Journal of Hematology & Oncology 2012, 5:8 http://www.jhoonline.org/content/5/1/8
JournalJournal of Hematology & Oncology
Rights© 2012 Li et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)
Collection InformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at email@example.com.
AbstractRecent morphologic and molecular genetic studies have led to a paradigm shift in our conceptualization of the carcinogenesis and histogenesis of pelvic (non-uterine) serous carcinomas. It appears that both low-grade and high-grade pelvic serous carcinomas that have traditionally been classified as ovarian in origin, actually originate, at least in a significant subset, from the distal fallopian tube. Clonal expansions of the tubal secretory cell probably give rise to serous carcinomas, and the degree of ciliated conversion is a function of the degree to which the genetic hits deregulate normal differentiation. In this article, the authors review the evidentiary basis for aforementioned paradigm shift, as well as its potential clinical implications.
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