Hsp90 depletion goes wild
| dc.contributor.author | Siegal, Mark | |
| dc.contributor.author | Masel, Joanna | |
| dc.date.accessioned | 2016-05-20T09:03:52Z | |
| dc.date.available | 2016-05-20T09:03:52Z | |
| dc.date.issued | 2012 | en |
| dc.identifier.citation | Siegal and Masel BMC Biology 2012, 10:14 http://www.biomedcentral.com/1741-7007/10/14 | en |
| dc.identifier.doi | 10.1186/1741-7007-10-14 | en |
| dc.identifier.uri | http://hdl.handle.net/10150/610309 | |
| dc.description.abstract | Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation.See research article http://wwww.biomedcentral.com/1471-2148/12/25 webcite | |
| dc.language.iso | en | en |
| dc.publisher | BioMed Central | en |
| dc.relation.url | http://www.biomedcentral.com/1741-7007/10/14 | en |
| dc.rights | © 2012 Siegal and Masel; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0). | en |
| dc.rights.uri | https://creativecommons.org/licenses/by/2.0/ | |
| dc.title | Hsp90 depletion goes wild | en |
| dc.type | Article | en |
| dc.identifier.eissn | 1741-7007 | en |
| dc.contributor.department | Center for Genomics and Systems Biology, Department of Biology, New York University, 12 Waverly Place, New York, NY 10003, USA | en |
| dc.contributor.department | Department of Ecology and Evolutionary Biology, University of Arizona, 1041 E. Lowell St, Tucson, AZ 85721, USA | en |
| dc.identifier.journal | BMC Biology | en |
| dc.description.collectioninformation | This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu. | en |
| dc.eprint.version | Final published version | en |
| refterms.dateFOA | 2018-05-28T02:18:46Z | |
| html.description.abstract | Hsp90 reveals phenotypic variation in the laboratory, but is Hsp90 depletion important in the wild? Recent work from Chen and Wagner in BMC Evolutionary Biology has discovered a naturally occurring Drosophila allele that downregulates Hsp90, creating sensitivity to cryptic genetic variation. Laboratory studies suggest that the exact magnitude of Hsp90 downregulation is important. Extreme Hsp90 depletion might reactivate transposable elements and/or induce aneuploidy, in addition to revealing cryptic genetic variation.See research article http://wwww.biomedcentral.com/1471-2148/12/25 webcite |
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Except where otherwise noted, this item's license is described as © 2012 Siegal and Masel; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).