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    Neuroprotection in acute brain injury: an up-to-date review

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    Author
    Stocchetti, Nino
    Taccone, Fabio S.
    Citerio, Giuseppe
    Pepe, Paul E.
    Le Roux, Peter D.
    Oddo, Mauro
    Polderman, Kees H.
    Stevens, Robert D.
    Barsan, William
    Maas, Andrew IR
    Meyfroidt, Geert
    Bell, Michael J.
    Silbergleit, Robert
    Vespa, Paul M.
    Faden, Alan I.
    Helbok, Raimund
    Tisherman, Samuel
    Zanier, Elisa R.
    Valenzuela, Terence
    Wendon, Julia
    Menon, David K.
    Vincent, Jean-Louis
    Show allShow less
    Affiliation
    Department of Physiopathology and Transplant, Milan University
    Neuro ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
    Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles
    Department of Health Science, University of Milan-Bicocca, Ospedale San Gerardo
    NeuroIntensive Care, Department of Emergency and Intensive Care, Ospedale San Gerardo
    Department of Emergency Medicine, University of Texas Southwestern Medical Center at Dallas
    Department of Neurosurgery, Lankenau Medical Center
    Department of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Faculty of Biology and Medicine, University of Lausanne
    Department of Critical Care Medicine, University of Pittsburgh Medical Center
    Division of Neuroscience Critical Care, Division of Adult Critical Care, Johns Hopkins Medicine
    NETT Clinical Coordinating Center, University of Michigan
    Department of Neurosurgery, University Hospital Antwerp and University of Antwerp
    Department of Intensive Care, UZ Leuven, Campus Gasthuisberg
    Department of Critical Care Medicine and the Safar Center for Resuscitation Research, University of Pittsburgh Medical Center
    Department of Neurocritical Care, David Geffen School of Medicine at UCLA
    Center for Shock, Trauma & Anesthesiology Research (STAR), University of Maryland School of Medicine
    Department of Neurology, Neurocritical Care Unit, Innsbruck Medical University
    Department of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine
    IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscience
    Department of Emergency Medicine, University of Arizona
    Institute of Liver Studies, King’s College Hospital
    Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital
    Show allShow less
    Issue Date
    2015
    
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    Publisher
    BioMed Central Ltd
    Citation
    Stocchetti et al. Critical Care (2015) 19:186 DOI 10.1186/s13054-015-0887-8
    Journal
    Critical Care
    Rights
    © 2015 Stocchetti et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
    Collection Information
    This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.
    Abstract
    Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.
    EISSN
    1466-609X
    DOI
    10.1186/s13054-015-0887-8
    Version
    Final published version
    Additional Links
    http://www.ccforum.com/content/19/1/186
    ae974a485f413a2113503eed53cd6c53
    10.1186/s13054-015-0887-8
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