Taccone, Fabio S.
Pepe, Paul E.
Le Roux, Peter D.
Polderman, Kees H.
Stevens, Robert D.
Maas, Andrew IR
Bell, Michael J.
Vespa, Paul M.
Faden, Alan I.
Zanier, Elisa R.
Menon, David K.
AffiliationDepartment of Physiopathology and Transplant, Milan University
Neuro ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
Department of Intensive Care, Erasme Hospital, Université libre de Bruxelles
Department of Health Science, University of Milan-Bicocca, Ospedale San Gerardo
NeuroIntensive Care, Department of Emergency and Intensive Care, Ospedale San Gerardo
Department of Emergency Medicine, University of Texas Southwestern Medical Center at Dallas
Department of Neurosurgery, Lankenau Medical Center
Department of Intensive Care Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Faculty of Biology and Medicine, University of Lausanne
Department of Critical Care Medicine, University of Pittsburgh Medical Center
Division of Neuroscience Critical Care, Division of Adult Critical Care, Johns Hopkins Medicine
NETT Clinical Coordinating Center, University of Michigan
Department of Neurosurgery, University Hospital Antwerp and University of Antwerp
Department of Intensive Care, UZ Leuven, Campus Gasthuisberg
Department of Critical Care Medicine and the Safar Center for Resuscitation Research, University of Pittsburgh Medical Center
Department of Neurocritical Care, David Geffen School of Medicine at UCLA
Center for Shock, Trauma & Anesthesiology Research (STAR), University of Maryland School of Medicine
Department of Neurology, Neurocritical Care Unit, Innsbruck Medical University
Department of Surgery, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine
IRCCS – Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscience
Department of Emergency Medicine, University of Arizona
Institute of Liver Studies, King’s College Hospital
Division of Anaesthesia, University of Cambridge, Addenbrooke’s Hospital
MetadataShow full item record
PublisherBioMed Central Ltd
CitationStocchetti et al. Critical Care (2015) 19:186 DOI 10.1186/s13054-015-0887-8
Rights© 2015 Stocchetti et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
Collection InformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at firstname.lastname@example.org.
AbstractNeuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.
VersionFinal published version