Pros and cons of CLA consumption: an insight from clinical evidences
Affiliation
Biotechnology Division, Department of Botany, Enzyme Technology Laboratory, University of CalicutSchool of Animal and Comparative Biomedical Sciences, University of Arizona
Department of Molecular Biosciences, University of Graz
Issue Date
2015
Metadata
Show full item recordPublisher
BioMed CentralCitation
Benjamin et al. Nutrition & Metabolism 2015, 12:4 http://www.nutritionandmetabolism.com/content/12/1/4Journal
Nutrition & MetabolismRights
© 2015 Benjamin et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0).Collection Information
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.Abstract
This comprehensive review critically evaluates whether supposed health benefits propounded upon human consumption of conjugated linoleic acids (CLAs) are clinically proven or not. With a general introduction on the chemistry of CLA, major clinical evidences pertaining to intervention strategies, body composition, cardio-vascular health, immunity, asthma, cancer and diabetes are evaluated. Supposed adverse effects such as oxidative stress, insulin resistance, irritation of intestinal tract and milk fat depression are also examined. It seems that no consistent result was observed even in similar studies conducted at different laboratories, this may be due to variations in age, gender, racial and geographical disparities, coupled with type and dose of CLA supplemented. Thus, supposed promising results reported in mechanistic and pre-clinical studies cannot be extrapolated with humans, mainly due to the lack of inconsistency in analyses, prolonged intervention studies, follow-up studies and international co-ordination of concerted studies. Briefly, clinical evidences accumulated thus far show that CLA is not eliciting significantly promising and consistent health effects so as to uphold it as neither a functional nor a medical food.EISSN
1743-7075Version
Final published versionae974a485f413a2113503eed53cd6c53
10.1186/1743-7075-12-4
Scopus Count
Collections
Except where otherwise noted, this item's license is described as © 2015 Benjamin et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0).