Effectiveness of prophylactic retropharyngeal lymph node irradiation in patients with locally advanced head and neck cancer

Nguyen, Nam; Vock, Jacqueline; Vinh-Hung, Vincent; Almeida, Fabio; Ewell, Lars; Betz, Michael; Jang, Siyoung; Vo, Richard; Dutta, Suresh; Godinez, Juan; Karlsson, Ulf; Chi, Alexander

dc.contributor.author	Nguyen, Nam
dc.contributor.author	Vock, Jacqueline
dc.contributor.author	Vinh-Hung, Vincent
dc.contributor.author	Almeida, Fabio
dc.contributor.author	Ewell, Lars
dc.contributor.author	Betz, Michael
dc.contributor.author	Jang, Siyoung
dc.contributor.author	Vo, Richard
dc.contributor.author	Dutta, Suresh
dc.contributor.author	Godinez, Juan
dc.contributor.author	Karlsson, Ulf
dc.contributor.author	Chi, Alexander
dc.date.accessioned	2016-05-20T09:04:48Z
dc.date.available	2016-05-20T09:04:48Z
dc.date.issued	2012	en
dc.identifier.citation	Nguyen et al. BMC Cancer 2012, 12:253 http://www.biomedcentral.com/1471-2407/12/253	en
dc.identifier.doi	10.1186/1471-2407-12-253	en
dc.identifier.uri	http://hdl.handle.net/10150/610347
dc.description.abstract	BACKGROUND:The aim of the study is to assess the effectiveness of intensity-modulated radiotherapy (IMRT) or image-guided radiotherapy (IGRT) for the prevention of retropharyngeal nodal recurrences in locally advanced head and neck cancer.METHODS:A retrospective review of 76 patients with head and neck cancer undergoing concurrent chemoradiation or postoperative radiotherapy with IMRT or IGRT who were at risk for retropharyngeal nodal recurrences because of anatomic site (hypopharynx, nasopharynx, oropharynx) and/or the presence of nodal metastases was undertaken.The prevalence of retropharyngeal nodal recurrences was assessed on follow-up positron emission tomography (PET)-CT scans.RESULTS:At a median follow-up of 22months (4-53months), no patient developed retropharyngeal nodal recurrences.CONCLUSION:Prophylactic irradiation of retropharyngeal lymph nodes with IMRT or IGRT provides effective regional control for individuals at risk for recurrence in these nodes.
dc.language.iso	en	en
dc.publisher	BioMed Central	en
dc.relation.url	http://www.biomedcentral.com/1471-2407/12/253	en
dc.rights	© 2012 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).	en
dc.rights.uri	https://creativecommons.org/licenses/by/2.0/
dc.subject	Head and neck cancer	en
dc.subject	IMRT	en
dc.subject	IGRT	en
dc.subject	Retropharyngeal lymph nodes	en
dc.title	Effectiveness of prophylactic retropharyngeal lymph node irradiation in patients with locally advanced head and neck cancer	en
dc.type	Article	en
dc.identifier.eissn	1471-2407	en
dc.contributor.department	Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA	en
dc.contributor.department	Department of Radiation Oncology, University of Bern, Bern, Switzerland, NC, USA	en
dc.contributor.department	Department of Radiation Oncology, University Hospitals of Geneva, Switzerland, Geneva, USA	en
dc.contributor.department	University of Galveston Medical School, Galveston, TX, USA	en
dc.contributor.department	San Antonio Cancer Center, San Antonio, TX, USA	en
dc.contributor.department	Florida Radiation Oncology Group, Palatka, FL, USA	en
dc.contributor.department	Marshfield Clinic, Marshfield, WI, USA	en
dc.contributor.department	Radiation Oncology, University of Arizona, 1501 N. Campbell Ave, Tucson, AZ 85724-5081, USA	en
dc.contributor.department	Department of Radiation Oncology, Southwest PET/CT Institute, Tucson, AZ, USA	en
dc.identifier.journal	BMC Cancer	en
dc.description.collectioninformation	This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.	en
dc.eprint.version	Final published version	en
refterms.dateFOA	2018-08-15T04:52:06Z
html.description.abstract	BACKGROUND:The aim of the study is to assess the effectiveness of intensity-modulated radiotherapy (IMRT) or image-guided radiotherapy (IGRT) for the prevention of retropharyngeal nodal recurrences in locally advanced head and neck cancer.METHODS:A retrospective review of 76 patients with head and neck cancer undergoing concurrent chemoradiation or postoperative radiotherapy with IMRT or IGRT who were at risk for retropharyngeal nodal recurrences because of anatomic site (hypopharynx, nasopharynx, oropharynx) and/or the presence of nodal metastases was undertaken.The prevalence of retropharyngeal nodal recurrences was assessed on follow-up positron emission tomography (PET)-CT scans.RESULTS:At a median follow-up of 22months (4-53months), no patient developed retropharyngeal nodal recurrences.CONCLUSION:Prophylactic irradiation of retropharyngeal lymph nodes with IMRT or IGRT provides effective regional control for individuals at risk for recurrence in these nodes.

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© 2012 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).

Except where otherwise noted, this item's license is described as © 2012 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).