Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer
Affiliation
Department of Radiation Oncology, Howard University Hospital, 2401 Georgia Avenue, N.W., Room 2055, Washington, DC 20060, USADepartment of Radiation Oncology, Lindenhofspital, Bern, Switzerland
Department of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland
Department of Radiation Oncology, University of West Virginia, Morgantown, WV, USA
Department of Biostatistics, East Carolina University, Greenville, NC, USA
Department of Pathology, University of Arizona, Tucson, AZ, USA
Department of Pediatry, University of Virginia, Charlottesville, VA, USA
Department of Radiation Oncology, Akron City Hospital, Akron, OH, USA
Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA
Issue Date
2014Metadata
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BioMed CentralCitation
Nguyen et al. BMC Cancer 2014, 14:265 http://www.biomedcentral.com/1471-2407/14/265Journal
BMC CancerRights
© 2014 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).Collection Information
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.Abstract
BACKGROUND:In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.METHODS:A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70Gy (62.4-75Gy).RESULTS:At a median follow-up of 14months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.CONCLUSIONS:IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.EISSN
1471-2407Version
Final published versionAdditional Links
http://www.biomedcentral.com/1471-2407/14/265Scopus Count
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Except where otherwise noted, this item's license is described as © 2014 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).