Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer

Nguyen, Nam; Jang, Siyoung; Vock, Jacqueline; Vinh-Hung, Vincent; Chi, Alexander; Vos, Paul; Pugh, Judith; Vo, Richard; Ceizyk, Misty; Desai, Anand; Smith-Raymond, Lexie; the International Geriatric, Radiotherapy Group

dc.contributor.author	Nguyen, Nam
dc.contributor.author	Jang, Siyoung
dc.contributor.author	Vock, Jacqueline
dc.contributor.author	Vinh-Hung, Vincent
dc.contributor.author	Chi, Alexander
dc.contributor.author	Vos, Paul
dc.contributor.author	Pugh, Judith
dc.contributor.author	Vo, Richard
dc.contributor.author	Ceizyk, Misty
dc.contributor.author	Desai, Anand
dc.contributor.author	Smith-Raymond, Lexie
dc.contributor.author	the International Geriatric, Radiotherapy Group
dc.date.accessioned	2016-05-20T09:04:52Z
dc.date.available	2016-05-20T09:04:52Z
dc.date.issued	2014	en
dc.identifier.citation	Nguyen et al. BMC Cancer 2014, 14:265 http://www.biomedcentral.com/1471-2407/14/265	en
dc.identifier.doi	10.1186/1471-2407-14-265	en
dc.identifier.uri	http://hdl.handle.net/10150/610350
dc.description.abstract	BACKGROUND:In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.METHODS:A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70Gy (62.4-75Gy).RESULTS:At a median follow-up of 14months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.CONCLUSIONS:IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.
dc.language.iso	en	en
dc.publisher	BioMed Central	en
dc.relation.url	http://www.biomedcentral.com/1471-2407/14/265	en
dc.rights	© 2014 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).	en
dc.rights.uri	https://creativecommons.org/licenses/by/2.0/
dc.subject	Esophageal cancer	en
dc.subject	Tomotherapy	en
dc.subject	Normal tissue sparing	en
dc.title	Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer	en
dc.type	Article	en
dc.identifier.eissn	1471-2407	en
dc.contributor.department	Department of Radiation Oncology, Howard University Hospital, 2401 Georgia Avenue, N.W., Room 2055, Washington, DC 20060, USA	en
dc.contributor.department	Department of Radiation Oncology, Lindenhofspital, Bern, Switzerland	en
dc.contributor.department	Department of Radiation Oncology, University Hospitals of Geneva, Geneva, Switzerland	en
dc.contributor.department	Department of Radiation Oncology, University of West Virginia, Morgantown, WV, USA	en
dc.contributor.department	Department of Biostatistics, East Carolina University, Greenville, NC, USA	en
dc.contributor.department	Department of Pathology, University of Arizona, Tucson, AZ, USA	en
dc.contributor.department	Department of Pediatry, University of Virginia, Charlottesville, VA, USA	en
dc.contributor.department	Department of Radiation Oncology, Akron City Hospital, Akron, OH, USA	en
dc.contributor.department	Department of Radiation Oncology, University of Arizona, Tucson, AZ, USA	en
dc.identifier.journal	BMC Cancer	en
dc.description.collectioninformation	This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.	en
dc.eprint.version	Final published version	en
refterms.dateFOA	2018-06-15T05:12:27Z
html.description.abstract	BACKGROUND:In this study the feasibility of intensity-modulated radiotherapy (IMRT) and tomotherapy-based image-guided radiotherapy (IGRT) for locally advanced esophageal cancer was assessed.METHODS:A retrospective study of ten patients with locally advanced esophageal cancer who underwent concurrent chemotherapy with IMRT (1) and IGRT (9) was conducted. The gross tumor volume was treated to a median dose of 70Gy (62.4-75Gy).RESULTS:At a median follow-up of 14months (1-39 months), three patients developed local failures, six patients developed distant metastases, and complications occurred in two patients (1 tracheoesophageal fistula, 1 esophageal stricture requiring repeated dilatations). No patients developed grade 3-4 pneumonitis or cardiac complications.CONCLUSIONS:IMRT and IGRT may be effective for the treatment of locally advanced esophageal cancer with acceptable complications.

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© 2014 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).

Except where otherwise noted, this item's license is described as © 2014 Nguyen et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).