Predictors of recurrence free survival for patients with stage II and III colon cancer
Affiliation
Department of Surgery, Oregon Health & Science University, Portland, Oregon, USADepartment of Surgery, The Mayo Clinic, Rochester, Minnesota, 200 First Street SW, 55905 Rochester, MN, USA
Department of Health Sciences Research, The Mayo Clinic, Rochester, Minnesota, 200 First Street SW, 55905 Rochester, MN, USA
Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, 1333 N. Martin Avenue, 85721 Tucson, Arizona, USA
Issue Date
2014Keywords
ChemotherapyDisease-free survival
Early stage colon cancer
Clinico-pathologic
Predictors of recurrence
Metadata
Show full item recordPublisher
BioMed CentralCitation
Tsikitis et al. BMC Cancer 2014, 14:336 http://www.biomedcentral.com/1471-2407/14/336Journal
BMC CancerRights
© 2014 Tsikitis et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).Collection Information
This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.Abstract
BACKGROUND:The aim of this study was to evaluate clinico-pathologic specific predictors of recurrence for stage II/III disease. Improving recurrence prediction for resected stage II/III colon cancer patients could alter surveillance strategies, providing opportunities for more informed use of chemotherapy for high risk individuals.METHODS:871 stage II and 265 stage III patients with colon cancers were included. Features studied included surgery date, age, gender, chemotherapy, tumor location, number of positive lymph nodes, tumor differentiation, and lymphovascular and perineural invasion. Time to recurrence was evaluated, using Cox's proportional hazards models. The predictive ability of the multivariable models was evaluated using the concordance (c) index.RESULTS:For stage II cancer patients, estimated recurrence-free survival rates at one, three, five, and seven years following surgery were 98%, 92%, 90%, and 89%. Only T stage was significantly associated with recurrence. Estimated recurrence-free survival rates for stage III patients at one, three, five, and seven years following surgery were 94%, 78%, 70%, and 66%. Higher recurrence rates were seen in patients who didn't receive chemotherapy (p=0.023), with a higher number of positive nodes (p<0.001). The c-index for the stage II model was 0.55 and 0.68 for stage III.CONCLUSIONS:Current clinic-pathologic information is inadequate for prediction of colon cancer recurrence after resection for stage II and IIII patients. Identification and clinical use of molecular markers to identify the earlier stage II and III colon cancer patients at elevated risk of recurrence are needed to improve prognostication of early stage colon cancers.EISSN
1471-2407Version
Final published versionAdditional Links
http://www.biomedcentral.com/1471-2407/14/336ae974a485f413a2113503eed53cd6c53
10.1186/1471-2407-14-336
Scopus Count
Collections
Except where otherwise noted, this item's license is described as © 2014 Tsikitis et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0).