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dc.contributor.authorCardinal, Matthew
dc.contributor.authorPhillips, Tania
dc.contributor.authorEisenbud, David
dc.contributor.authorHarding, Keith
dc.contributor.authorMansbridge, Jonathan
dc.contributor.authorArmstrong, David
dc.date.accessioned2016-05-20T09:05:16Z
dc.date.available2016-05-20T09:05:16Z
dc.date.issued2009en
dc.identifier.citationBMC Dermatology 2009, 9:2 doi:10.1186/1471-5945-9-2en
dc.identifier.doi10.1186/1471-5945-9-2en
dc.identifier.urihttp://hdl.handle.net/10150/610368
dc.description.abstractBACKGROUND:The purpose of this manuscript was to determine whether the change in wound surface area over time could be described through nonlinear mathematics.METHODS:We studied 3,588 serial wound tracings of 338 venous leg ulcers (VLUs) that had been followed during a controlled, prospective, randomized trial of two topical wound treatments.RESULTS:A majority (72%) of VLUs exhibited surface area reduction via an exponential decay model, particularly during the early stages of healing. These results were consistent with the mechanics of wound contraction and epithelial cell proliferation, supported by the higher frequency at which exponential surface area reduction associated with full wound closure (35% of wounds that fit the exponential model healed vs. 21% of wounds that did not fit the exponential model completely healed during the study period, p = 0.018). Goodness-of-fit statistics suggested that much of the individual variation in healing could be described as nonlinear variation from the exponential model.CONCLUSION:We believe that parameter estimates from a mathematical model may provide a more accurate quantification of wound healing rates, and that similar models may someday reach routine use in comparing the efficacy of various treatments in routine practice and in product registration trials.
dc.language.isoenen
dc.publisherBioMed Centralen
dc.relation.urlhttp://www.biomedcentral.com/1471-5945/9/2en
dc.rights© 2009 Cardinal et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0)en
dc.titleNonlinear modeling of venous leg ulcer healing ratesen
dc.typeArticleen
dc.identifier.eissn1471-5945en
dc.contributor.departmentAdvanced BioHealing, La Jolla, CA, USAen
dc.contributor.departmentBoston University School of Medicine, Boston, MA, USAen
dc.contributor.departmentSouthern Arizona Limb Salvage Alliance (SALSA), Department of Surgery, University of Arizona, Tucson, Arizona USAen
dc.contributor.departmentCardiff University School of Medicine, Wales, UKen
dc.contributor.departmentTecellact, La Jolla, California, USAen
dc.identifier.journalBMC Dermatologyen
dc.description.collectioninformationThis item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at repository@u.library.arizona.edu.en
dc.eprint.versionFinal published versionen
refterms.dateFOA2018-06-14T22:05:18Z
html.description.abstractBACKGROUND:The purpose of this manuscript was to determine whether the change in wound surface area over time could be described through nonlinear mathematics.METHODS:We studied 3,588 serial wound tracings of 338 venous leg ulcers (VLUs) that had been followed during a controlled, prospective, randomized trial of two topical wound treatments.RESULTS:A majority (72%) of VLUs exhibited surface area reduction via an exponential decay model, particularly during the early stages of healing. These results were consistent with the mechanics of wound contraction and epithelial cell proliferation, supported by the higher frequency at which exponential surface area reduction associated with full wound closure (35% of wounds that fit the exponential model healed vs. 21% of wounds that did not fit the exponential model completely healed during the study period, p = 0.018). Goodness-of-fit statistics suggested that much of the individual variation in healing could be described as nonlinear variation from the exponential model.CONCLUSION:We believe that parameter estimates from a mathematical model may provide a more accurate quantification of wound healing rates, and that similar models may someday reach routine use in comparing the efficacy of various treatments in routine practice and in product registration trials.


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