QUANTITATIVE MEASUREMENT OF THE EXPRESSION OF TWO GENES IN THE CORETX AND CEREBELLUM OF A MOUSE MODEL OF JUVENILE ALZHEIMER’S
AuthorMARSHALL, CRAIG ANTHONY
AdvisorErickson, Robert P.
MetadataShow full item record
PublisherThe University of Arizona.
RightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.
AbstractThere is a continuing effort in order to connect the two neurodegenerative diseases: Alzheimer’s Disease and Niemann-Pick Type C Disease (NPC1) “Juvenile Alzheimer’s”. Here in this study, we attempted to determine if there was a connection through the gene expression in inflammatory genes, CD14 and ETS-1, in a NPC1 mouse model, Npc1nmf164, using quantitative real time PCR. Hydroxypropyl-beta-cyclodextrin (HPβCD) is reported to provide a beneficial effect on NPC1, and there was interest in seeing if HPβCD treatment could return the expression levels to wildtype levels. Instead, only a significant decrease of the CD14 and ETS-1 in cerebellar tissue of untreated NPC1 affected mice (when compared to wildtype levels), and no significant difference for the treated, affected mice was seen. CD14 p value = 0.026, and ETS-1 p value = 0.014. There was no significant difference found in cortex tissue for either CD14 or ETS-1.
Degree ProgramHonors College