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dc.contributor.advisorWilson, Jeanen
dc.contributor.authorPaluszcyk, Chana Renee
dc.creatorPaluszcyk, Chana Reneeen
dc.date.accessioned2016-06-16T16:26:55Z
dc.date.available2016-06-16T16:26:55Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10150/613371
dc.description.abstractMyasthenia gravis (MG) is an autoimmune disease whose name means "grave muscular weakness". MG is a rare disease affecting only 200-400 persons per million and the characteristic symptoms include muscle weakness, particularly in highly active voluntary muscles. MG affects the neuromuscular junction in an antibody-mediated manner, resulting in impaired nerve-muscle cell communication in affected individuals. Specifically, two main proteins are targeted: nicotinic acetylcholine receptors (ACh receptors) and a muscle-specific tyrosine kinase (MuSK). Previous studies have discovered the mechanism of MG pathogenesis but the exact mechanisms which cause the failure to maintain self-tolerance have not been discovered. Based on current knowledge of MG, this paper will explore potential causes of the disease and provide numerous hypotheses directed at future research opportunities.
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.subjectComplement systemen
dc.subjectMyasthenia gravisen
dc.subjectnicotinic acetylcholine receptoren
dc.subjectCellular and Molecular Medicineen
dc.subjectAutoimmuneen
dc.titleThe Future of Myasthenia Gravis: Exploring the Onset, Progression and Implications of Diseaseen_US
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.grantorUniversity of Arizonaen
thesis.degree.levelmastersen
dc.contributor.committeememberElliott, Daviden
dc.contributor.committeememberLybarger, Lonnieen
dc.contributor.committeememberRiggs, Michaelen
thesis.degree.disciplineGraduate Collegeen
thesis.degree.disciplineCellular and Molecular Medicineen
thesis.degree.nameM.S.en
refterms.dateFOA2018-06-27T11:24:08Z
html.description.abstractMyasthenia gravis (MG) is an autoimmune disease whose name means "grave muscular weakness". MG is a rare disease affecting only 200-400 persons per million and the characteristic symptoms include muscle weakness, particularly in highly active voluntary muscles. MG affects the neuromuscular junction in an antibody-mediated manner, resulting in impaired nerve-muscle cell communication in affected individuals. Specifically, two main proteins are targeted: nicotinic acetylcholine receptors (ACh receptors) and a muscle-specific tyrosine kinase (MuSK). Previous studies have discovered the mechanism of MG pathogenesis but the exact mechanisms which cause the failure to maintain self-tolerance have not been discovered. Based on current knowledge of MG, this paper will explore potential causes of the disease and provide numerous hypotheses directed at future research opportunities.


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