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dc.contributor.advisorZinsmaier, Konraden
dc.contributor.authorSEO, HOJIN
dc.creatorSEO, HOJINen
dc.date.accessioned2016-06-17T20:58:52Z
dc.date.available2016-06-17T20:58:52Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10150/613604
dc.description.abstractTGF-β signaling is particularly well studied for its role in early embryonic patterning and cell proliferation specific to cancer progression. At the larval neuromuscular junction (NMJ) of the model organism Drosophila melanogaster, several ligands from the TGF-β superfamily have been shown to promote synaptic growth and evoked neurotransmitter release. We focused on the retrograde bone morphogenic protein (BMP) signaling pathway and its potential role for the presynaptic expression of WD40, a potential cofactor of the E3 ubiquitin ligase Cullin 4 (Cul4) that is required for evoked neurotransmitter release. The goal of this project was to investigate whether this TGF-β signaling pathway regulates the expression of WD40. In conclusion, our data shows evidence that WD40 might a critical effector of retrograde BMP signaling at Drosophila NMJs.
dc.language.isoen_USen
dc.publisherThe University of Arizona.en
dc.rightsCopyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author.en
dc.titleRETROGRADE TGF-β SIGNALING AND ITS EFFECTS ON WD40 AT THE DROSOPHILA NEUROMUSCULAR JUNCTIONen_US
dc.typetexten
dc.typeElectronic Thesisen
thesis.degree.grantorUniversity of Arizonaen
thesis.degree.levelBachelorsen
thesis.degree.disciplineHonors Collegeen
thesis.degree.disciplineMolecular and Cellular Biologyen
thesis.degree.nameB.S.en
refterms.dateFOA2018-06-24T05:52:43Z
html.description.abstractTGF-β signaling is particularly well studied for its role in early embryonic patterning and cell proliferation specific to cancer progression. At the larval neuromuscular junction (NMJ) of the model organism Drosophila melanogaster, several ligands from the TGF-β superfamily have been shown to promote synaptic growth and evoked neurotransmitter release. We focused on the retrograde bone morphogenic protein (BMP) signaling pathway and its potential role for the presynaptic expression of WD40, a potential cofactor of the E3 ubiquitin ligase Cullin 4 (Cul4) that is required for evoked neurotransmitter release. The goal of this project was to investigate whether this TGF-β signaling pathway regulates the expression of WD40. In conclusion, our data shows evidence that WD40 might a critical effector of retrograde BMP signaling at Drosophila NMJs.


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