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    Evaluation of the Quality of Amiodarone with Macrolides and Fluoroquinolones Drug-Drug Interactions Reported in the Literature

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    Author
    Do, Brian
    Patel, Pritesh
    Yee, Kevin
    Malone, Daniel
    Affiliation
    College of Pharmacy, The University of Arizona
    Issue Date
    2015
    Keywords
    amiodarone
    macrolides
    fluoroquinolones
    drug-drug
    interactions
    MeSH Subjects
    Amiodarone
    Macrolides
    Fluoroquinolones
    Drug Interactions
    Advisor
    Malone, Daniel
    
    Metadata
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    Rights
    Copyright © is held by the author.
    Collection Information
    This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.
    Publisher
    The University of Arizona.
    Abstract
    Objectives: To determine the quality of evidence in the literature reporting the potential effect of QT prolongation and cardiovascular interactions of amiodarone with fluoroquinolones and macrolides. Methods: A thorough database search was conducted utilizing PubMed, Embase, Micromedex, and Facts and Comparison. Studies were eligible if they involved human subjects, original submission in English, and focusing on any drugs within the macrolide class along with amiodarone or any drugs within the fluoroquinolone class along with amiodarone was included. Drug-drug interactions (DDI) within the literature were evaluated using one of two tools: (1) van Roon to assess the quality of randomized controlled studies, and (2) the Drug Interaction Probability Scale (DIPS) to assess case reports. Results: Five case reports were included for evaluation. None of the patients within the case reports were less than 65 years old. Four of the five case reports included ciprofloxacin as part of the proposed drug interaction with amiodarone. The range of DIPS scores were 4-7 with a median score of 6. Conclusions: The evidence purporting this drug-drug interaction is of poor quality and low quantity. Additional studies of high quality must be conducted on the subject of this DDI to provide clinicians the ability to make more informed clinical decisions.
    Description
    Class of 2015 Abstract
    Collections
    Pharmacy Student Research Projects

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