• Login
    View Item 
    •   Home
    • UA Graduate and Undergraduate Research
    • Pharmacy Student Research Projects
    • View Item
    •   Home
    • UA Graduate and Undergraduate Research
    • Pharmacy Student Research Projects
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UA Campus RepositoryCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournal

    My Account

    LoginRegister

    About

    AboutUA Faculty PublicationsUA DissertationsUA Master's ThesesUA Honors ThesesUA PressUA YearbooksUA CatalogsUA Libraries

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Evaluation of the Occurrence of Hypermanganesemia in Patients on Long-Term Parenteral Nutrition

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Author
    Lowrey, Olga
    Thaler, Laura
    Matthias, Kathryn
    Rollins, Carol
    Affiliation
    College of Pharmacy, The University of Arizona
    Issue Date
    2013
    Keywords
    Hypermanganesemia
    Nutrition
    Parenteral
    MeSH Subjects
    Manganese
    Parenteral Nutrition
    Advisor
    Matthias, Kathryn
    Rollins, Carol
    
    Metadata
    Show full item record
    Rights
    Copyright © is held by the author.
    Collection Information
    This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.
    Publisher
    The University of Arizona.
    Abstract
    Specific Aims: Trace elements such as manganese are added into parenteral nutrition formulations to prevent or treat trace elements deficiencies. Excessive amounts of certain trace elements added to parenteral nutritional formulations can cause potential adverse effects. The purpose of this study was to evaluate whole-blood manganese concentrations obtained in patients prescribed parenteral nutrition for more than 30 days. The manganese concentrations obtained were evaluated based on the duration and amount of manganese prescribed in the parenteral nutritional formulations.. Methods: In this IRB approved project, adult patients prescribed parenteral nutrition for at least 30 consecutive days at an academic medical center or through the outpatient healthcare system between January 2007 and December 2011 were evaluated. Subjects were excluded if no manganese concentrations were obtained while parenteral nutrition was prescribed. Manganese concentrations were grouped by duration that trace elements were added to parenteral nutrition formulations as < 30 days, 30-90 days, 90-365 days, and >365 days. A fifth group of manganese concentrations were evaluated if they were obtained when manganese was not added to the parenteral nutritional formulation for at least 90 days. Data collected included demographic information, reason for initiation and discontinuation of parenteral nutrition, reason for long-term parenteral nutrition, duration of parenteral nutrition, duration and timing of other nutrient sources, amount prescribed and timing of trace elements, trace element concentrations, and documentation of potential manganese toxicity in medical records. A normal manganese concentration was defined as 4.2 to 16.5 mcg/L. Main Results: A total of 27 subjects who were prescribed long-term parenteral nutrition were evaluated. Subjects had a median age of 54 years and range of 18 to 71 years. The majority of subjects (53%) were initially prescribed parenteral nutrition for enteric fistula or malabsorption issues while 27% of subjects were classified as have short gut. A total of 41 manganese concentrations were reported with a median value of 20.1 mcg/L and range of 9.1 to 49.9 mcg/L. The percentage of abnormally high manganese concentrations was 0% at 0-30 days, 63% at 30-90 days, 83% at 90-365 days, and 100% at >365 days of parenteral nutrition with manganese added through a multitrace element solution. In subjects who had received parenteral nutrition for at least 90 days without manganese, abnormal manganese concentrations reported rate was 28%. The rate of abnormal manganese concentrations was significant different between 0-30 days compared to 90-365 days (p = 0.015) and > 365 days (p =0.09) of multi-trace element added to parenteral nutrition. The median number of days between the initial day of parenteral nutition and day managanese concentration checked was 131 days and ranged from 0 to 849 days. Conclusion: The majority of commercially available trace element solutions contain approximately 500% per mL of the recommended daily supplementation amount. In 27 subjects who received long-term parenteral nutrition, the risk of hypermanganesemia was significantly associated with durations of parenteral nutrition that contained multi-trace element solutions for more than 90 days.
    Description
    Class of 2013 Abstract
    Collections
    Pharmacy Student Research Projects

    entitlement

     
    The University of Arizona Libraries | 1510 E. University Blvd. | Tucson, AZ 85721-0055
    Tel 520-621-6442 | repository@u.library.arizona.edu
    DSpace software copyright © 2002-2017  DuraSpace
    Quick Guide | Contact Us | Send Feedback
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.