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    Comparison of Morphine and Fentanyl For Pain Due to Traumatic Injury in the Emergency Department

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    Author
    Wenderoth, Bradley
    Kaneda, Elizabeth
    Patanwala, Asad E.
    Affiliation
    College of Pharmacy, The University of Arizona
    Issue Date
    2011
    Keywords
    MORPHINE
    FENTANYL
    PAIN
    TRAUMATIC INJURY
    EMERGENCY DEPARTMENT
    MeSH Subjects
    Morphine
    Fentanyl
    Wounds and Injuries
    Emergency Service, Hospital
    Advisor
    Patanwala, Asad E.
    
    Metadata
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    Rights
    Copyright © is held by the author.
    Collection Information
    This item is part of the Pharmacy Student Research Projects collection, made available by the College of Pharmacy and the University Libraries at the University of Arizona. For more information about items in this collection, please contact Jennifer Martin, Librarian and Clinical Instructor, Pharmacy Practice and Science, jenmartin@email.arizona.edu.
    Publisher
    The University of Arizona.
    Abstract
    OBJECTIVES: To compare fixed equianalgesic doses of morphine and fentanyl with regard to analgesic response for patients who presented to the ED with moderate to severe pain. METHODS: A retrospective cohort study of clinical data obtained through patient medical record review. Median pain reduction on the numeric pain scale was compared between the morphine and fentanyl groups. Independent variables of interest included: Age, sex, weight, initial pain score, injury severity, triage severity and injury type. RESULTS: : Pain scores were reported to be worse in the fentanyl group, p= 0.0002. However pain reduction was similar between the groups; median (IQR) of 2 (1-3) and 2 (1-4) in the morphine and fentanyl groups respectively, p= 0.6707. Injuries were more severe in the fentanyl group; injury severity score (ISS) median (IQR) of 5 (1-9) and 9 (3-12), p=0.0312 and more patients in the fentanyl group required additional opioids within 30 min of their first ED opioid dose, 15 (18%) and 31 (37%), p=0.006. CONCLUSION: Patients in both the morphine and fentanyl groups received similar analgesic response. Patients in the fentanyl group had a higher severity of injury, received higher doses of opioids from the EMS, and required the second dose of opioid sooner than patients in the morphine group.
    Description
    Class of 2011 Abstract
    Collections
    Pharmacy Student Research Projects

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