Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications
AffiliationUniv Arizona, Dept Elect & Comp Engn
Univ Arizona, Coll Pharm
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CitationMicrofluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications 2016, 16 (4):476 Sensors
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AbstractTHz spectroscopy is an emerging technique for studying the dynamics and interactions of cells and biomolecules, but many practical challenges still remain in experimental studies. We present a prototype of simple and inexpensive cell-trapping microfluidic chip for THz spectroscopic study of live cells. Cells are transported, trapped and concentrated into the THz exposure region by applying an AC bias signal while the chip maintains a steady temperature at 37 degrees C by resistive heating. We conduct some preliminary experiments on E. coli and T-cell solution and compare the transmission spectra of empty channels, channels filled with aqueous media only, and channels filled with aqueous media with un-concentrated and concentrated cells.
VersionFinal published version
SponsorsThis research was partly supported by a national research council research associateship award at Air Force Research Laboratory, Radio Frequency Bioeffects Branch, Fort Sam, Houston, TX, USA. The authors are very grateful for the support from Dr. Tingting Liu, and Dr. Abram Young.